DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10984 and ankrd12

DIOPT Version :9

Sequence 1:	NP_729823.2	Gene:	CG10984 / 39446	FlyBaseID:	FBgn0036305	Length:	658	Species:	Drosophila melanogaster
Sequence 2:	XP_031759102.1	Gene:	ankrd12 / 100170448	XenbaseID:	XB-GENE-5860751	Length:	2011	Species:	Xenopus tropicalis

Alignment Length:	709	Identity:	181/709 - (25%)
Similarity:	302/709 - (42%)	Gaps:	196/709 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PPRPK-GIGFNTGATQPR--SNSNTPMSERQQMALLIQ---MTANSSTVQSQSLELLLVGLNFNL 61
            ||:|: .:..||..:.|.  |.:|.|:|.:|..|::.:   ..||||:|:.:
Frog  1444 PPQPQSNLVVNTAVSDPLYFSKTNPPISSKQVHAIVNEEQTHCANSSSVKIE------------- 1495

  Fly    62 HHSSRTTLKKNECKKGDAETDEGSLNEKQEVLDTKDKS--SAEESSNDGKSSDTNHQGTSAAKRC 124
                            |:|::       .:::.|:|.|  |||        |..|.|...:.|..
Frog  1496 ----------------DSESE-------VKLIQTEDTSLCSAE--------SSVNSQTIESIKIV 1529

  Fly   125 YSDIE-EDYEESGEDVKKKKRKDSEHGKDVKGASLKLTSRVEKSSKLAATKGSPSGNKSSASNAE 188
            .:|:. ||....|::                  ::::::.|.....|...:|....|.:.:.:|.
Frog  1530 LTDVTVEDLPSEGDE------------------AMQVSTEVNTDISLCNPEGIELENIADSDSAP 1576

  Fly   189 KEPAETSKN------------VDIENETECSDDYKSNDSLYNGGLKVPPLKIVIPQQNCSIDTEG 241
            |:....::|            .||....|.::..|.|           |.:.||||.:.:..||
Frog  1577 KQDKSITENTASSALINVKCDTDIVQGCETTEITKDN-----------PDQQVIPQSSSAHTTE- 1629

  Fly   242 NVLRTGKVTASRNAALPYVVSSNSDSIDTVITNQSISPH-ESPQKSNSICSTALD--DKNIKLFN 303
                                                ||. |.||...|...:.|.  |::::.|:
Frog  1630 ------------------------------------SPKTEQPQYPLSAFESPLPQLDQDMQSFS 1658

  Fly   304 DEKNLRVLRSSHRTGVTSVERSSNNSSPQMQSSSPSPASSNHANDPAD----VKLSYSNMTSSPI 364
            ..              ..:|...|..........|...:.|.||..|:    |:.:||
Frog  1659 QP--------------AKMEAEENTEEKAEHQEIPQRITRNRANMLANQNKQVQTNYS------- 1702

  Fly   365 PQGHQFDQEAITNVPSPSTSSTSSSKDINPSNVEL-HPRKRKI----RPKNTDDS-----SKNSN 419
               |..|:|.:.:..|.......:.:|    :|:: ||||||:    :|...:.|     .|...
Frog  1703 ---HSSDKETVESPVSLRGRIRLTEED----DVQVHHPRKRKMARVPQPGLANSSVMQAKEKTQQ 1760

  Fly   420 AADSGVNS---EESHPHDHPFTNGFQMFLSIRRQIEKKWKSLYPVKPRPPQGYNEYLLTKKSYLL 481
            :..:.|:|   ::..|:.....|.:..:|.|||::|::.|.|..|.|:.||.|:||:....||||
Frog  1761 SLAAVVDSLKLDDIQPYQSERANPYFEYLHIRRKVEERRKMLCSVIPQAPQYYDEYVTFNGSYLL 1825

  Fly   482 RRN--ATISVPDI--PRTVPQAMERIYQDQEKARRDLIEAHTVEREKLCMNVEQEIIRVHSKAAR 542
            ..|  :.:.:|.|  |.::.:.::.:::.||..|..|...|::|||||.::.|||::|||.:|||
Frog  1826 DGNPFSKLCIPTITPPPSLSEPLKELFRQQEVVRMKLRLQHSIEREKLIVSNEQEVLRVHYRAAR 1890

  Fly   543 SISGQPAPYSVCTYLKDDEVYNMITPEQDEKEK-SARCRFNGRLLLSWLQDVDDKWEKIKESMVL 606
            :::.|..|:|.||.|.|.||||:....|.|..| |.|.|||.|..:|||||||:|::|:|..:::
Frog  1891 TLANQSLPFSACTVLLDAEVYNVPQESQTEDGKASVRDRFNARQFMSWLQDVDEKFDKLKTCLLM 1955

  Fly   607 RHHNEAESLHAVQVMDWNIFAKRNRLCDNP--------IEVNLEHVPIVSVGDDFDTLP 657
            |..:||.:|:|||.::|.:  |...|  :|        .|:....||:|.|.|||:..|
Frog  1956 RQQHEAAALNAVQRLEWQL--KLQEL--DPATYKSVSIYEIQEFSVPLVEVNDDFELTP 2010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CG10984	NP_729823.2	None
ankrd12	XP_031759102.1	ANKYR	113..301	CDD:223738
		ANK repeat	184..215	CDD:293786
		Ank_2	189..274	CDD:403870
		ANK repeat	217..248	CDD:293786
		ANK repeat	250..275	CDD:293786
		PTZ00121	<716..1053	CDD:173412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2898
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006031
OrthoInspector	1	1.000	-	-		otm49516
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5253
SonicParanoid	1	1.000	-	-		X4941
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.940