DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klc and PEA2

DIOPT Version :9

Sequence 1:	NP_001261780.1	Gene:	Klc / 39445	FlyBaseID:	FBgn0010235	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_011076.1	Gene:	PEA2 / 856892	SGDID:	S000000951	Length:	420	Species:	Saccharomyces cerevisiae

Alignment Length:	187	Identity:	41/187 - (21%)
Similarity:	73/187 - (39%)	Gaps:	58/187 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 AEVQKDNEKSDMLRKNIENIELGLSEAQVM-MALTSHLQNIEAEKHKLKTQVRRLHQENAWLRDE 98
            |.:|:::..     |.:|.:|...|:.|:. ..||...:|..||   ....:.:|.:.|..|:|:
Yeast   234 AAIQEEDSS-----KKLEELETAFSDLQLAHNFLTKQFENDRAE---YVQDIEKLTRTNRELQDK 290

  Fly    99 LANTQQKFQASEQLVAQLEEEKKHLEFMASVKKYDENQEQDDACDKSRTDPVVELFPDEENEDRH 163
            |.|.......:|:.:.:||:|.|.||                   |:.         ::.|..||
Yeast   291 LLNNHSNLSKTEKKLHELEQENKELE-------------------KAN---------NKLNSSRH 327

  Fly   164 NM------------SPTPPSQFANQTSGYEIPARLRTLHNLVIQY-----ASQGRYE 203
            |.            .|:.||...:.|||    :..|:|..:..::     ::|.:||
Yeast   328 NFGMSSPASSPVTWDPSSPSSVGSPTSG----SGSRSLSIMTSEFKKVLTSTQRKYE 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klc	NP_001261780.1	TPR_12	185..258	CDD:315987	5/24 (21%)
		TPR repeat	187..214	CDD:276809	5/22 (23%)
		TPR_12	226..302	CDD:315987
		TPR repeat	228..256	CDD:276809
		TPR_12	269..344	CDD:315987
		TPR repeat	270..298	CDD:276809
		TPR_12	310..384	CDD:315987
		TPR repeat	311..341	CDD:276809
		TPR_12	353..469	CDD:315987
		TPR repeat	354..381	CDD:276809
PEA2	NP_011076.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2043
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950