DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klc and KLCR1

DIOPT Version :9

Sequence 1:	NP_001261780.1	Gene:	Klc / 39445	FlyBaseID:	FBgn0010235	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_192822.1	Gene:	KLCR1 / 826680	AraportID:	AT4G10840	Length:	609	Species:	Arabidopsis thaliana

Alignment Length:	352	Identity:	80/352 - (22%)
Similarity:	129/352 - (36%)	Gaps:	96/352 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 TLHNLVIQYASQGRYEVAVPLCKQALEDLERTSGHDHP--------DVATMLNILALVYRDQNKY 244
            :||.|...|.|.||::.|||..::|::..:.|.|.||.        .:...|::|..:.|....|
plant   142 SLHVLAAIYCSLGRFDEAVPPLERAIQVPDPTRGPDHSLAAFSGHMQLGDTLSMLGQIDRSIACY 206

  Fly   245 KEAANLLNDALSIRGKTLGENHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIREKVLGKDHP 309
            :|       .|.|:.:|||:..|.|..|...||..|.:..::..||.|||:.|||..........
plant   207 EE-------GLKIQIQTLGDTDPRVGETCRYLAEAYVQAMQFNKAEELCKKTLEIHRAHSEPASL 264

  Fly   310 DVAKQLNNLALLCQNQGKY----------------------------------------DEVEKY 334
            :.|.....:|::|:.:|.|                                        ||....
plant   265 EEAADRRLMAIICEAKGDYENALEHLVLASMAMIASGQESEVASIDVSIGNIYMSLCRFDEAVFS 329

  Fly   335 YQRALDIYESKLGPDDPNVAKTKNNLAGCYLKQGRYTEAE--------ILYKQVLTRAHEREFGA 391
            ||:||.::::..|...|.||.....||..|.:.|:..|::        |..|.|.....|...|.
plant   330 YQKALTVFKASKGETHPTVASVFVRLAELYHRTGKLRESKSYCENALRIYNKPVPGTTVEEIAGG 394

  Fly   392 IDSKNKPIWQVAEEREEHKFDNRENTPYGEYGGWHKAAKV---------DSPTVTTTLKNL---- 443
            : ::...|::..:|.||                   |.|:         |.|...:.:..|
plant   395 L-TEISAIYESVDEPEE-------------------ALKLLQKSMKLLEDKPGQQSAIAGLEARM 439

  Fly   444 GALYRRQGMFEAAETLEDCAMRSKKEA 470
            |.:|...|.:|.|....:.|:...:.|
plant   440 GVMYYTVGRYEDARNAFESAVTKLRAA 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klc	NP_001261780.1	TPR_12	185..258	CDD:315987	21/77 (27%)
		TPR repeat	187..214	CDD:276809	11/25 (44%)
		TPR_12	226..302	CDD:315987	24/75 (32%)
		TPR repeat	228..256	CDD:276809	5/27 (19%)
		TPR_12	269..344	CDD:315987	24/114 (21%)
		TPR repeat	270..298	CDD:276809	9/27 (33%)
		TPR_12	310..384	CDD:315987	23/121 (19%)
		TPR repeat	311..341	CDD:276809	11/69 (16%)
		TPR_12	353..469	CDD:315987	27/136 (20%)
		TPR repeat	354..381	CDD:276809	8/34 (24%)
KLCR1	NP_192822.1	TPR_12	88..169	CDD:315987	11/26 (42%)
		TPR_12	138..215	CDD:315987	22/79 (28%)
		TPR repeat	140..168	CDD:276809	11/25 (44%)
		TPR repeat	178..212	CDD:276809	7/40 (18%)
		TPR repeat	225..253	CDD:276809	9/27 (33%)
		TPR	229..500	CDD:223533	52/258 (20%)
		TPR repeat	259..290	CDD:276809	5/30 (17%)
		TPR repeat	348..378	CDD:276809	7/29 (24%)
		TPR repeat	392..420	CDD:276809	7/47 (15%)
		TPR repeat	438..468	CDD:276809	7/29 (24%)
		TPR repeat	473..506	CDD:276809
		TPR_12	476..548	CDD:315987
		TPR repeat	516..544	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810