DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klc and Nphp3

DIOPT Version :9

Sequence 1:	NP_001261780.1	Gene:	Klc / 39445	FlyBaseID:	FBgn0010235	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_082997.3	Gene:	Nphp3 / 74025	MGIID:	1921275	Length:	1325	Species:	Mus musculus

Alignment Length:	532	Identity:	154/532 - (28%)
Similarity:	226/532 - (42%)	Gaps:	141/532 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 GLSEAQVM--------MALTS---------------------HLQNIEA------EKHKLKTQVR 86
            |:||:::|        ::|||                     |||..|.      |...|.:..|
Mouse   777 GVSESELMELYPEMSWLSLTSIVHSLHKMHLLTYSCGLLRFQHLQAWETVRLQYLEDPALVSSYR 841

  Fly    87 ---------RLHQENAWLR--DELANTQQKFQASEQ---------LVAQLEEEKKHL-------- 123
                     :|.|:....|  |||....|: |.|:|         ||||...::.|.
Mouse   842 EKLISYFASQLSQDRVTWRSADELPWLFQQ-QGSKQKLHSCLLNLLVAQNLYKRGHFAELLSYWQ 905

  Fly   124 -----------EFMASVKKYDENQ-EQDDACDKSRTDPVVELFPDEENEDR---------HNMSP 167
                       |:..|:|:|:.:: |::..|       :.:|:   |...|         ..:.|
Mouse   906 FVGKDKGAMATEYFESLKQYENSEGEENMLC-------LADLY---ETLGRFLKDLGLLSQAVVP 960

  Fly   168 TPPSQFANQTS-GYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLERTSGHDHPDVATML 231
            ...|....:|: ..:.|...::||.|...|....::..|..|.|||||..|...|.|||..|..|
Mouse   961 LQRSLEIRETALDPDHPRVAQSLHQLAGVYVQWKKFGDAEQLYKQALEISENAYGADHPHAAREL 1025

  Fly   232 NILALVYRDQNKYKEA------------------------ANLLNDALSIRGKTLGENHPAVAAT 272
            ..||.:|..||||::|                        |.|...||.:...|||::.|..|.|
Mouse  1026 EALATLYHKQNKYEQAEHFRKKSVIIRQQATRRKGSLYGFALLRRRALQLEELTLGKDKPENART 1090

  Fly   273 LNNLAVLYGKRGKYKDAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYDEVEKYYQR 337
            ||.|.|||..:...:.||...||:||:||:|||.||||.|:.|||||.||..:.:|::.|:.|:|
Mouse  1091 LNELGVLYFLQNNLETAEQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYEKAEELYER 1155

  Fly   338 ALDIYESKLGPDDPNVAKTKNNLAGCYLKQGRYTEAEILYKQVLTRAHEREFG----AIDSKNKP 398
            ||||....|.||.|::|.|..:||..|.|.|:..:|..|| ::.....::.||    ::.:....
Mouse  1156 ALDIRRRALAPDHPSLAYTVKHLAILYKKTGKVDKAVPLY-ELAVEIRQKSFGPKHPSVATALVN 1219

  Fly   399 IWQVAEEREEHKFDNRENTPYGEYGGWHKAAKV--DS-----PTVTTTLKNLGALYRRQGMFEAA 456
            :..:..:.::|.    |..|.     :.:|.|:  ||     |.|..|||||..|...:|.||.|
Mouse  1220 LAVLHSQMKKHS----EALPL-----YERALKIYEDSLGRMHPRVGETLKNLAVLSYEEGNFEKA 1275

  Fly   457 ETLEDCAMRSKK 468
            ..|...||..|:
Mouse  1276 AELYKRAMEIKE 1287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klc	NP_001261780.1	TPR_12	185..258	CDD:315987	30/96 (31%)
		TPR repeat	187..214	CDD:276809	9/26 (35%)
		TPR_12	226..302	CDD:315987	33/99 (33%)
		TPR repeat	228..256	CDD:276809	13/51 (25%)
		TPR_12	269..344	CDD:315987	39/74 (53%)
		TPR repeat	270..298	CDD:276809	12/27 (44%)
		TPR_12	310..384	CDD:315987	31/73 (42%)
		TPR repeat	311..341	CDD:276809	14/29 (48%)
		TPR_12	353..469	CDD:315987	35/127 (28%)
		TPR repeat	354..381	CDD:276809	10/26 (38%)
Nphp3	NP_082997.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Kinesin-relat_1	76..145	CDD:289481
		Uso1_p115_C	113..199	CDD:282695
		OmpH	<120..>202	CDD:281871
		TPR 1	467..500
		P-loop_NTPase	502..>570	CDD:304359
		TPR 2	881..914		5/32 (16%)
		TPR 3	916..937		6/27 (22%)
		TPR_12	937..1012	CDD:290160	18/77 (23%)
		TPR_10	937..978	CDD:290111	6/43 (14%)
		TPR 4	938..971		5/35 (14%)
		TPR repeat	938..966	CDD:276809	5/30 (17%)
		TPR_12	976..1054	CDD:290160	27/77 (35%)
		TPR repeat	976..1009	CDD:276809	11/32 (34%)
		TPR_10	979..1020	CDD:290111	15/40 (38%)
		TPR 5	980..1013		12/32 (38%)
		TPR repeat	1022..1074	CDD:276809	13/51 (25%)
		TPR 6	1022..1055		10/32 (31%)
		TPR_12	1085..1162	CDD:290160	40/76 (53%)
		TPR_10	1088..1128	CDD:290111	21/39 (54%)
		TPR 7	1088..1121		16/32 (50%)
		TPR repeat	1088..1116	CDD:276809	12/27 (44%)
		TPR_12	1126..1204	CDD:290160	33/78 (42%)
		TPR_10	1130..1169	CDD:290111	19/38 (50%)
		TPR 8	1130..1163		16/32 (50%)
		TPR repeat	1130..1158	CDD:276809	13/27 (48%)
		TPR_12	1168..1246	CDD:290160	18/87 (21%)
		TPR repeat	1168..1201	CDD:276809	11/33 (33%)
		TPR 9	1172..1205		10/33 (30%)
		TPR_10	1177..1211	CDD:290111	10/34 (29%)
		TPR_12	1210..1288	CDD:290160	23/87 (26%)
		TPR_10	1213..1254	CDD:290111	7/49 (14%)
		TPR 10	1214..1247		5/41 (12%)
		TPR repeat	1214..1242	CDD:276809	4/36 (11%)
		TPR 11	1256..1289		14/32 (44%)
		TPR repeat	1256..1284	CDD:276809	12/27 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1293..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810