DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klc and Ttc19

DIOPT Version :9

Sequence 1:	NP_001261780.1	Gene:	Klc / 39445	FlyBaseID:	FBgn0010235	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_082636.3	Gene:	Ttc19 / 72795	MGIID:	1920045	Length:	365	Species:	Mus musculus

Alignment Length:	328	Identity:	76/328 - (23%)
Similarity:	141/328 - (42%)	Gaps:	70/328 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 AWLRDELANTQQKFQ-ASEQLVAQLEEEKKHLEFMASVKKYDENQEQDDACDKSRTDPVVELFPD 156
            ||.....|..:|..: ||::..|::.:..|..:.  |:.|     ::.:|.:....|.:...:
Mouse    63 AWFSRPAATAEQPGEDASDEAEAEIIQLLKQAKL--SIMK-----DEPEAAELILHDALRLAY-- 118

  Fly   157 EENEDRHNMSPTPPSQFANQTSGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLERTSG 221
             |:::|..::.|           |::.|.|..:         :|:.|.|..|.|..:..| ...|
Mouse   119 -ESDNRKAITYT-----------YDLMANLAFI---------RGQLENAEQLFKATMSYL-LGGG 161

  Fly   222 HDHPDVATMLNI---LALVYRDQNK-------YKEAANLLNDALSIRGKTLGEN---------HP 267
            ....|.| ::.|   ||.:|..|||       |:...:.|...:. |.|.|.|:         :.
Mouse   162 MKQEDNA-IIEISLKLANIYAAQNKQEFALAGYEFCISTLEGKIE-REKELAEDIMSEETANTYL 224

  Fly   268 AVAATLNNLA--VLYGKRGKYKDAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYDE 330
            .:...|::.|  :|:.|  :...|:.:.::||:|.:::.|:.||.....:::||.....||.:|:
Mouse   225 LLGMCLDSCARYLLFSK--QLSQAQRMYEKALQICQEIQGERHPQTIVLMSDLATTLDAQGHFDD 287

  Fly   331 VEKYYQRALDIYESKLGPDDPNVAKTKNNLAGCYLKQGRYTEAEILYKQVLTRA----------H 385
            ...|.|||.|:...   .:.|.:....:|||...:.:.|||:|:.:|::.|.||          |
Mouse   288 AYIYMQRASDLARE---INHPELHMVLSNLAAILIHRERYTQAKEIYQEALKRAELKRDEVSVQH 349

  Fly   386 ERE 388
            .||
Mouse   350 IRE 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klc	NP_001261780.1	TPR_12	185..258	CDD:315987	19/82 (23%)
		TPR repeat	187..214	CDD:276809	5/26 (19%)
		TPR_12	226..302	CDD:315987	23/96 (24%)
		TPR repeat	228..256	CDD:276809	10/37 (27%)
		TPR_12	269..344	CDD:315987	21/76 (28%)
		TPR repeat	270..298	CDD:276809	6/29 (21%)
		TPR_12	310..384	CDD:315987	20/73 (27%)
		TPR repeat	311..341	CDD:276809	9/29 (31%)
		TPR_12	353..469	CDD:315987	14/46 (30%)
		TPR repeat	354..381	CDD:276809	8/26 (31%)
Ttc19	NP_082636.3	TPR 1	127..160		10/53 (19%)
		TPR_12	217..301	CDD:290160	21/85 (25%)
		TPR 2	220..260		8/41 (20%)
		TPR repeat	220..255	CDD:276809	6/36 (17%)
		TPR_12	265..339	CDD:290160	23/76 (30%)
		TPR repeat	268..298	CDD:276809	9/29 (31%)
		TPR 3	269..302		10/35 (29%)
		TPR 4	308..341		11/32 (34%)
		TPR repeat	308..336	CDD:276809	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810