DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klc and Ttc19

DIOPT Version :9

Sequence 1:	NP_001261780.1	Gene:	Klc / 39445	FlyBaseID:	FBgn0010235	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_006246592.1	Gene:	Ttc19 / 691506	RGDID:	1582808	Length:	365	Species:	Rattus norvegicus

Alignment Length:	319	Identity:	67/319 - (21%)
Similarity:	131/319 - (41%)	Gaps:	78/319 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 ENQEQDDACDKSRTDPV-------VELFPDE----------------ENEDRHNMSPTPPSQFAN 175
            |.|..:||.|::..:.:       :.:..||                |::::..::.|
  Rat    72 EEQPGEDATDEAEAEIIQLLKRAKLSIMKDEPEAAELILHDALRLAYESDNKKAITYT------- 129

  Fly   176 QTSGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLERTSGHDHPDVATMLNI-LALVYR 239
                |::.|.|..:         :|:.|.|..|.|..:..|.........:....::: ||.:|.
  Rat   130 ----YDLMANLAFI---------RGQLENAEQLFKATMSYLLGGGMKQEDNAIVEISLKLANIYA 181

  Fly   240 DQNK-------YKEAANLLNDALSIRGKTLGEN---------HPAVAATLNNLA--VLYGKRGKY 286
            .|||       |:...:.|...:. |.|.|.|:         :..:...|::.|  :|:.|  :.
  Rat   182 AQNKQEFALAGYEFCISTLEGKIE-REKELAEDIMSEERANTYLLLGMCLDSCARYLLFSK--QL 243

  Fly   287 KDAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYDEVEKYYQRALDIYESKLGPDDP 351
            ..|:.:.::||:|.:::.|:.||.....:::||.....||.:|:...|.|||.|:...   .:.|
  Rat   244 SQAQRMYEKALQICQEIQGERHPQTIVLMSDLATALDAQGHFDDAYIYMQRASDLARE---INHP 305

  Fly   352 NVAKTKNNLAGCYLKQGRYTEAEILYKQVLTRAHER--EFGAIDSKNKPIWQVAEEREE 408
            .:....:|||...:.:.|||:|:.:|::.|.:|..:  ||.        :..:.||..|
  Rat   306 ELHMVLSNLAAILIHRERYTQAKEIYQEALKQAELKRDEFS--------VQHIREELAE 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klc	NP_001261780.1	TPR_12	185..258	CDD:315987	15/80 (19%)
		TPR repeat	187..214	CDD:276809	5/26 (19%)
		TPR_12	226..302	CDD:315987	20/94 (21%)
		TPR repeat	228..256	CDD:276809	8/35 (23%)
		TPR_12	269..344	CDD:315987	21/76 (28%)
		TPR repeat	270..298	CDD:276809	6/29 (21%)
		TPR_12	310..384	CDD:315987	20/73 (27%)
		TPR repeat	311..341	CDD:276809	9/29 (31%)
		TPR_12	353..469	CDD:315987	15/58 (26%)
		TPR repeat	354..381	CDD:276809	8/26 (31%)
Ttc19	XP_006246592.1	TPR repeat	220..255	CDD:276809	6/36 (17%)
		TPR_12	224..301	CDD:290160	21/78 (27%)
		BRO1_Alix_like	<231..339	CDD:301330	30/112 (27%)
		TPR_12	265..339	CDD:290160	22/76 (29%)
		TPR repeat	268..298	CDD:276809	9/29 (31%)
		TPR repeat	308..336	CDD:276809	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810