DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Klc and KLC2

DIOPT Version :9

Sequence 1:NP_001261780.1 Gene:Klc / 39445 FlyBaseID:FBgn0010235 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_001128247.1 Gene:KLC2 / 64837 HGNCID:20716 Length:622 Species:Homo sapiens


Alignment Length:500 Identity:340/500 - (68%)
Similarity:401/500 - (80%) Gaps:20/500 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 QMSQDEIITNTKTVLQGLEALRVEHVSIM-------NGIAEVQKDNEKSDMLRKNIENIELGLSE 60
            ::|||||:..||.|:||||.||.||.:::       .|.|| ....|:..:||:::|.|||||.|
Human    11 KLSQDEIVLGTKAVIQGLETLRGEHRALLAPLVAPEAGEAE-PGSQERCILLRRSLEAIELGLGE 74

  Fly    61 AQVMMALTSHLQNIEAEKHKLKTQVRRLHQENAWLRDELANTQQKFQASEQLVAQLEEEKKHLEF 125
            |||::||:|||..:|:||.||:.|||||.|||.|||:|||.||||.|.|||.||||||||:||.|
Human    75 AQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREELAGTQQKLQRSEQAVAQLEEEKQHLLF 139

  Fly   126 MASVKKYDE----NQEQDDACDKSRTDPVVELFPDEENEDRHNMSPTP-PSQFANQTSGYEIPAR 185
            |:.::|.||    |:|:.|.    ..|.:.:|||   |||..:.:|:| ....:.|..|||||||
Human   140 MSQIRKLDEDASPNEEKGDV----PKDTLDDLFP---NEDEQSPAPSPGGGDVSGQHGGYEIPAR 197

  Fly   186 LRTLHNLVIQYASQGRYEVAVPLCKQALEDLERTSGHDHPDVATMLNILALVYRDQNKYKEAANL 250
            ||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||:|
Human   198 LRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHL 262

  Fly   251 LNDALSIRGKTLGENHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIREKVLGKDHPDVAKQL 315
            |||||:||.||||::||||||||||||||||||||||:||||||||||||||||||.||||||||
Human   263 LNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQL 327

  Fly   316 NNLALLCQNQGKYDEVEKYYQRALDIYESKLGPDDPNVAKTKNNLAGCYLKQGRYTEAEILYKQV 380
            :|||||||||||.:|||.||:|||:||.::||||||||||||||||.||||||:|.:||.|||::
Human   328 SNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEI 392

  Fly   381 LTRAHEREFGAIDSKNKPIWQVAEEREEHKFDNRENTPYGEYGGWHKAAKVDSPTVTTTLKNLGA 445
            ||||||:|||:::..|||||..||||||.|...|::.||||||.|:||.|||||||.|||::|||
Human   393 LTRAHEKEFGSVNGDNKPIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSLGA 457

  Fly   446 LYRRQGMFEAAETLEDCAMRSKKEAYDLAKQTKLSQLLTSNEKRR 490
            ||||||..|||.||||||.|::|:..|.|.|||:.:||.....||
Human   458 LYRRQGKLEAAHTLEDCASRNRKQGLDPASQTKVVELLKDGSGRR 502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KlcNP_001261780.1 TPR_12 185..258 CDD:315987 69/72 (96%)
TPR repeat 187..214 CDD:276809 26/26 (100%)
TPR_12 226..302 CDD:315987 69/75 (92%)
TPR repeat 228..256 CDD:276809 26/27 (96%)
TPR_12 269..344 CDD:315987 66/74 (89%)
TPR repeat 270..298 CDD:276809 26/27 (96%)
TPR_12 310..384 CDD:315987 57/73 (78%)
TPR repeat 311..341 CDD:276809 24/29 (83%)
TPR_12 353..469 CDD:315987 81/115 (70%)
TPR repeat 354..381 CDD:276809 20/26 (77%)
KLC2NP_001128247.1 SMC_N <9..>139 CDD:330553 74/128 (58%)
MreC 76..>149 CDD:327530 48/72 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 145..191 16/52 (31%)
TPR_12 197..272 CDD:315987 71/74 (96%)
TPR 1 198..231 32/32 (100%)
TPR repeat 199..226 CDD:276809 26/26 (100%)
TPR_12 238..314 CDD:315987 69/75 (92%)
TPR 2 240..273 29/32 (91%)
TPR repeat 240..268 CDD:276809 26/27 (96%)
TPR_12 281..354 CDD:315987 64/72 (89%)
TPR 3 282..315 31/32 (97%)
TPR repeat 282..310 CDD:276809 26/27 (96%)
TPR_12 322..396 CDD:315987 57/73 (78%)
TPR repeat 323..353 CDD:276809 24/29 (83%)
TPR 4 324..357 25/32 (78%)
TPR_12 365..481 CDD:315987 81/115 (70%)
TPR 5 366..399 25/32 (78%)
TPR repeat 366..393 CDD:276809 20/26 (77%)
TPR 6 449..482 23/32 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 476..548 10/26 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 563..622
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 192 1.000 Domainoid score I3215
eggNOG 1 0.900 - - E2759_KOG1840
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 698 1.000 Inparanoid score I680
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D238239at33208
OrthoFinder 1 1.000 - - FOG0002344
OrthoInspector 1 1.000 - - otm41970
orthoMCL 1 0.900 - - OOG6_102564
Panther 1 1.100 - - O PTHR45783
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1545
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.830

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