DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klc and TTC19

DIOPT Version :9

Sequence 1:	NP_001261780.1	Gene:	Klc / 39445	FlyBaseID:	FBgn0010235	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_060245.3	Gene:	TTC19 / 54902	HGNCID:	26006	Length:	380	Species:	Homo sapiens

Alignment Length:	355	Identity:	76/355 - (21%)
Similarity:	137/355 - (38%)	Gaps:	92/355 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 AWLRDELANTQQKFQASEQLVAQLEEEKKHLEFMASVKK------YDENQEQD----DAC----- 142
            ||.....|..:::.|.::...|:...::...|.:..:|:      .||.:|.:    ||.
Human    64 AWFSRPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILHDALRLAYQ 128

  Fly   143 --DKSRTDPVVELFPD-------EENEDRHNMSPTPPSQFANQTSGYEIPARLRTLHNLVIQ--- 195
              :|.......:|..:       .||.:          |....|..|.:...::...|.:|:
Human   129 TDNKKAITYTYDLMANLAFIRGQLENAE----------QLFKATMSYLLGGGMKQEDNAIIEISL 183

  Fly   196 -----YASQGRYEVAV---PLCKQALEDLERTSGHDHPDVATMLNILALVYRDQNKYKEAANLLN 252
                 ||:|.|.|.||   ..|...||:                           |.:....|..
Human   184 KLASIYAAQNRQEFAVAGYEFCISTLEE---------------------------KIEREKELAE 221

  Fly   253 DALSIRGKTLGENHPAVAATLNNLA--VLYGKRGKYKDAEPLCKRALEIREKVLGKDHPDVAKQL 315
            |.:|:..|  ...|..:...|:..|  :|:.|:.  ..|:.:.::||:|.|::.|:.||.....:
Human   222 DIMSVEEK--ANTHLLLGMCLDACARYLLFSKQP--SQAQRMYEKALQISEEIQGERHPQTIVLM 282

  Fly   316 NNLALLCQNQGKYDEVEKYYQRALDIYESKLGPDDPNVAKTKNNLAGCYLKQGRYTEAEILYKQV 380
            ::||.....||::||...|.|||.|:...   .:.|.:....:|||...:.:.|||:|:.:|::.
Human   283 SDLATTLDAQGRFDEAYIYMQRASDLARQ---INHPELHMVLSNLAAVLMHRERYTQAKEIYQEA 344

  Fly   381 LTRA----------HER-EFGAIDSKNKPI 399
            |.:|          |.| |...:..|::|:
Human   345 LKQAKLKKDEISVQHIREELAELSKKSRPL 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klc	NP_001261780.1	TPR_12	185..258	CDD:315987	16/83 (19%)
		TPR repeat	187..214	CDD:276809	10/37 (27%)
		TPR_12	226..302	CDD:315987	14/77 (18%)
		TPR repeat	228..256	CDD:276809	3/27 (11%)
		TPR_12	269..344	CDD:315987	23/76 (30%)
		TPR repeat	270..298	CDD:276809	6/29 (21%)
		TPR_12	310..384	CDD:315987	21/73 (29%)
		TPR repeat	311..341	CDD:276809	10/29 (34%)
		TPR_12	353..469	CDD:315987	15/58 (26%)
		TPR repeat	354..381	CDD:276809	8/26 (31%)
TTC19	NP_060245.3	TPR 1	136..169		6/42 (14%)
		TPR 2	179..212		11/59 (19%)
		TPR_12	233..311	CDD:290160	24/79 (30%)
		TPR 3	237..270		9/34 (26%)
		TPR_12	275..349	CDD:290160	23/76 (30%)
		TPR repeat	278..308	CDD:276809	10/29 (34%)
		TPR 4	279..312		11/35 (31%)
		TPR 5	318..351		10/32 (31%)
		TPR repeat	318..346	CDD:276809	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810