DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klc and NPHP3

DIOPT Version :9

Sequence 1:	NP_001261780.1	Gene:	Klc / 39445	FlyBaseID:	FBgn0010235	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_694972.3	Gene:	NPHP3 / 27031	HGNCID:	7907	Length:	1330	Species:	Homo sapiens

Alignment Length:	503	Identity:	149/503 - (29%)
Similarity:	224/503 - (44%)	Gaps:	85/503 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LQGLEALRVEHVSIMNGIAEVQKDNEKSDMLRKNIENIELGLSEAQVMMALTSHLQNI---EAEK 78
            ||..|.:|:|:         ::.....|...:|.|....|.||:.:|.......|..:   :..|
Human   824 LQAWETVRLEY---------LEGPTVTSSYRQKLINYFTLQLSQDRVTWRSADELPWLFQQQGSK 879

  Fly    79 HKLKTQVRRLH-QENAWLRDELANTQQKFQASEQLVAQLEEEKKHLEFMASVKKYDENQEQDD-- 140
            .||...:..|. .:|.:.|...|.....:    |.|.: ::.....|:..|:|:|::|.|.:|
Human   880 QKLHDCLLNLFVSQNLYKRGHFAELLSYW----QFVGK-DKSAMATEYFDSLKQYEKNCEGEDNM 939

  Fly   141 ACDKSRTDPVVELFPDEENEDR---------HNMSPTPPSQFANQTS-GYEIPARLRTLHNLVIQ 195
            :|       :.:|:   |...|         ..:.|...|....:|: ..:.|...::||.|...
Human   940 SC-------LADLY---ETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASV 994

  Fly   196 YASQGRYEVAVPLCKQALEDLERTSGHDHPDVATMLNILALVYRDQNKYKEA------------- 247
            |....::..|..|.|||||..|...|.|||..|..|..||.:|:.||||::|
Human   995 YVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQK 1059

  Fly   248 -----------ANLLNDALSIRGKTLGENHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIRE 301
                       |.|...||.:...|||::.|..|.|||.|.|||..:...:.|:...||:||:||
Human  1060 AIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRE 1124

  Fly   302 KVLGKDHPDVAKQLNNLALLCQNQGKYDEVEKYYQRALDIYESKLGPDDPNVAKTKNNLAGCYLK 366
            :|||.||||.|:.|||||.||..:.:||:.|:.|:|||||....|.||.|::|.|..:||..|.|
Human  1125 RVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKK 1189

  Fly   367 QGRYTEAEILYKQVLTRAHEREFG----AIDSKNKPIWQVAEEREEHKFDNRENTPYGEYGGWHK 427
            .|:..:|..|| ::.....::.||    ::.:....:..:..:.::|.    |..|.     :.:
Human  1190 MGKLDKAVPLY-ELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHV----EALPL-----YER 1244

  Fly   428 AAKV--DS-----PTVTTTLKNLGALYRRQGMFEAAETLEDCAMRSKK 468
            |.|:  ||     |.|..|||||..|....|.||.|..|...||..|:
Human  1245 ALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKE 1292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klc	NP_001261780.1	TPR_12	185..258	CDD:315987	30/96 (31%)
		TPR repeat	187..214	CDD:276809	9/26 (35%)
		TPR_12	226..302	CDD:315987	32/99 (32%)
		TPR repeat	228..256	CDD:276809	13/51 (25%)
		TPR_12	269..344	CDD:315987	39/74 (53%)
		TPR repeat	270..298	CDD:276809	11/27 (41%)
		TPR_12	310..384	CDD:315987	32/73 (44%)
		TPR repeat	311..341	CDD:276809	15/29 (52%)
		TPR_12	353..469	CDD:315987	35/127 (28%)
		TPR repeat	354..381	CDD:276809	10/26 (38%)
NPHP3	NP_694972.3	Kinesin-relat_1	80..149	CDD:289481
		Uso1_p115_C	117..203	CDD:282695
		OmpH	<124..>206	CDD:281871
		TPR 1	471..504
		TPR 2	885..918		6/37 (16%)
		TPR 3	920..942		8/28 (29%)
		TPR_12	942..1017	CDD:290160	18/77 (23%)
		TPR_10	942..983	CDD:290111	6/43 (14%)
		TPR 4	943..976		5/35 (14%)
		TPR repeat	943..971	CDD:276809	5/30 (17%)
		TPR_12	981..1059	CDD:290160	27/77 (35%)
		TPR_10	984..1025	CDD:290111	15/40 (38%)
		TPR 5	985..1018		12/32 (38%)
		TPR repeat	985..1013	CDD:276809	9/27 (33%)
		TPR repeat	1027..1079	CDD:276809	13/51 (25%)
		TPR 6	1027..1060		10/32 (31%)
		TPR_12	1090..1167	CDD:290160	40/76 (53%)
		TPR_10	1093..1133	CDD:290111	20/39 (51%)
		TPR 7	1093..1126		15/32 (47%)
		TPR repeat	1093..1121	CDD:276809	11/27 (41%)
		TPR_12	1131..1209	CDD:290160	34/78 (44%)
		TPR_10	1135..1174	CDD:290111	20/38 (53%)
		TPR 8	1135..1168		17/32 (53%)
		TPR repeat	1135..1163	CDD:276809	14/27 (52%)
		TPR_12	1173..1251	CDD:290160	18/87 (21%)
		TPR repeat	1173..1206	CDD:276809	11/33 (33%)
		TPR 9	1177..1210		10/33 (30%)
		TPR_10	1182..1216	CDD:290111	10/34 (29%)
		TPR_12	1215..1293	CDD:290160	23/87 (26%)
		TPR_10	1218..1259	CDD:290111	7/49 (14%)
		TPR 10	1219..1252		5/41 (12%)
		TPR repeat	1219..1247	CDD:276809	4/36 (11%)
		TPR 11	1261..1294		14/32 (44%)
		TPR repeat	1261..1289	CDD:276809	12/27 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1296..1330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1840
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810