Protein Alignment Klc and klc-1

DIOPT Version :9

• Sequence 1: NP_001261780.1
• Gene: Klc / 39445
• FlyBaseID: FBgn0010235
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_001255534.1
• Gene: klc-1 / 178007
• WormBaseID: WBGene00002214
• Length: 536
• Species: Caenorhabditis elegans
• Alignment Length: 515
• Identity: 226/515 - (43%)
• Similarity: 311/515 - (60%)
• Gaps: 53/515 - (10%)

  Fly     7 DEIITNTKTVLQGLEALRVEHVS---------IMNGIAEVQKDNEKSDMLRKNIENIELGLSEAQ 62
            |:|.|..|||.|.|.|||.||.:         |.:..:|....:||..::.:::..:..|..||.
 Worm    27 DDITTVLKTVQQTLFALRDEHEAATRILEANLINSDSSEPSLPSEKMGLIDESLGKVMDGGDEAS 91

  Fly    63 VMMALTSHLQNIEAEKHKLKTQVRRLHQENAWLRDELANTQQKFQASEQLVAQLEEEKKHLEFMA 127
            :::.:...:|:.:.:..|....:|.|.|||.||.|||..||:|.|.||:.||.||||:.|.:|..
 Worm    92 LLIMMDKLMQSYDVQLSKNHESIRLLRQENTWLLDELTTTQRKLQESERTVAHLEEERDHYKFQD 156

  Fly   128 SVKKYDENQEQDDACDKS--RTDPVVELFPDEENEDRHNMSPTP---PSQFANQTSG-YEIPARL 186
            |:...:.:.:...:.|.:  ..|.:.||....|.||::|.....   .|.|:|..|. |::|.||
 Worm   157 SMNYLNSDFQHTTSVDATPMMVDTLQELGFGPEEEDQNNNQADQGCRSSSFSNPISNDYQLPTRL 221

  Fly   187 RTLHNLVIQYASQGRYEVAVPLCKQALEDLERTSGHDHPDVATMLNILALVYRDQNKYKEAANLL 251
            :||.||||||..|||:|||:|||||||||:.:..|:.|.|||||||:||:|||:|..:|:||..|
 Worm   222 QTLQNLVIQYMEQGRFEVAIPLCKQALEDVVKVHGNVHLDVATMLNVLAIVYRNQENFKDAAIYL 286

  Fly   252 NDALSIRGKTLGENHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIREKVLGKDHPDVAKQLN 316
            ..|||||.:..||||.:|||||||||:.||||||||::|||||||||||:.:||.:||||||||.
 Worm   287 EKALSIRVQCCGENHHSVAATLNNLAIAYGKRGKYKESEPLCKRALEIRKNLLGPNHPDVAKQLT 351

  Fly   317 NLALLCQNQGKYDEVEKYYQRALDIYESKLGPDDPNVAKTKNNLAGCYLKQGRYTEAEILYKQVL 381
            ||.::.|...||:|.|.|:::||.||......:..||.||||.||..:||||:|.|||.:||.:|
 Worm   352 NLGIVTQQLEKYEETENYFKQALSIYNRAFPENHQNVIKTKNQLASVFLKQGKYQEAEEMYKNIL 416

  Fly   382 TRAHEREFGAIDSKNKPIWQVAEEREEHKFDNRENTPYGEYGGWHKAAKVD------SPT----- 435
            ::.      || :.|||||::||:|||.:   |...|           |||      :||
 Worm   417 SKV------AI-TGNKPIWRIAEDREERQ---RNGIP-----------KVDDESFNVNPTTVMDS 460

  Fly   436 -VTTTLKNLGALYRRQGMFEAAETLEDCAMRSKKEAYDLAKQTKLSQLLTSNEKRRSKAI 494
             |.:|:|||.|:||:||..|||.|||: |:.:||:....|..|.    .|::....|.|:
 Worm   461 NVMSTIKNLAAVYRKQGKEEAAGTLEE-ALGAKKQINGGADHTN----STASSVETSSAV 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klc	NP_001261780.1	TPR_12	185..258	CDD:315987	47/72 (65%)
		TPR repeat	187..214	CDD:276809	20/26 (77%)
		TPR_12	226..302	CDD:315987	54/75 (72%)
		TPR repeat	228..256	CDD:276809	16/27 (59%)
		TPR_12	269..344	CDD:315987	50/74 (68%)
		TPR repeat	270..298	CDD:276809	23/27 (85%)
		TPR_12	310..384	CDD:315987	37/73 (51%)
		TPR repeat	311..341	CDD:276809	15/29 (52%)
		TPR_12	353..469	CDD:315987	55/127 (43%)
		TPR repeat	354..381	CDD:276809	16/26 (62%)
klc-1	NP_001255534.1	TPR_12	220..293	CDD:315987	47/72 (65%)
		TPR repeat	222..249	CDD:276809	20/26 (77%)
		TPR_12	261..337	CDD:315987	54/75 (72%)
		TPR repeat	263..291	CDD:276809	16/27 (59%)
		TPR repeat	296..334	CDD:276809	29/37 (78%)
		TPR_12	303..379	CDD:315987	50/75 (67%)
		TPR repeat	347..375	CDD:276809	13/27 (48%)
		TPR repeat	389..417	CDD:276809	16/27 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160389
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2043
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D238239at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45783
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.860