Protein Alignment Klc and Klc1

DIOPT Version :10

• Sequence 1: NP_524049.1
• Gene: Klc / 39445
• FlyBaseID: FBgn0010235
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: XP_063117578.1
• Gene: Klc1 / 171041
• RGDID: 621411
• Length: 616
• Species: Rattus norvegicus
• Alignment Length: 513
• Identity: 355/513 - (69%)
• Similarity: 425/513 - (82%)
• Gaps: 27/513 - (5%)

  Fly     1 MTQMSQDEIITNTKTVLQGLEALRVEHVSIMNGIAE----VQKDN------EKSDMLRKNIENIE 55
            :.:::|||||:.||.|:||||||:.||.||:..:.|    ::||:      |||.|:||::|.:|
  Rat    16 LEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSSMIRKSLEMLE 80

  Fly    56 LGLSEAQVMMALTSHLQNIEAEKHKLKTQVRRLHQENAWLRDELANTQQKFQASEQLVAQLEEEK 120
            ||||||||||||::||..:|:||.||:.|||||.|||.||||||||||||.|.|||.||||||||
  Rat    81 LGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEK 145

  Fly   121 KHLEFMASVKKYDE--NQEQDDACDKSRTDPVVELFPDEEN------EDRHNMSPTPPSQFANQT 177
            ||||||..:||||:  :..:|...|.|: :|:.:|||::|:      :.:|:.:..     |.|.
  Rat   146 KHLEFMNQLKKYDDDISPSEDKDSDSSK-EPLDDLFPNDEDDPGQGIQQQHSSAAA-----AAQQ 204

  Fly   178 SGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLERTSGHDHPDVATMLNILALVYRDQN 242
            .|||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
  Rat   205 GGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQN 269

  Fly   243 KYKEAANLLNDALSIRGKTLGENHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIREKVLGKD 307
            |||:|||||||||:||.||||.:||||||||||||||||||||||:|||||||||||||||||||
  Rat   270 KYKDAANLLNDALAIREKTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKD 334

  Fly   308 HPDVAKQLNNLALLCQNQGKYDEVEKYYQRALDIYESKLGPDDPNVAKTKNNLAGCYLKQGRYTE 372
            |||||||||||||||||||||:|||.||||||:||::|||||||||||||||||.||||||::.:
  Rat   335 HPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQ 399

  Fly   373 AEILYKQVLTRAHEREFGAIDSKNKPIWQVAEEREEHKFDNRENTPYGEYGGWHKAAKVDSPTVT 437
            ||.|||::||||||||||::|.:|||||..||||||.|...::.:.:||||||:||.||||||||
  Rat   400 AETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGSSFGEYGGWYKACKVDSPTVT 464

  Fly   438 TTLKNLGALYRRQGMFEAAETLEDCAMRSKKEAYDLAKQTKLSQLLT---SNEKRRSK 492
            ||||||||||||||.||||||||:.|:||:|:..|...:.:::::|.   :.|||||:
  Rat   465 TTLKNLGALYRRQGKFEAAETLEEAALRSRKQGLDNVHKQRVAEVLNDPENVEKRRSR 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klc	NP_524049.1	TPR	183..>391	CDD:440225	187/207 (90%)
		TPR repeat	187..214	CDD:276809	26/26 (100%)
		TPR repeat	228..256	CDD:276809	26/27 (96%)
		TPR repeat	270..298	CDD:276809	26/27 (96%)
		TPR repeat	311..341	CDD:276809	27/29 (93%)
		TPR repeat	354..381	CDD:276809	19/26 (73%)
Klc1	XP_063117578.1	None