DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Klc and Klc2

DIOPT Version :10

Sequence 1:NP_524049.1 Gene:Klc / 39445 FlyBaseID:FBgn0010235 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_001356290.1 Gene:Klc2 / 16594 MGIID:107953 Length:636 Species:Mus musculus


Alignment Length:537 Identity:342/537 - (63%)
Similarity:411/537 - (76%) Gaps:45/537 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 QMSQDEIITNTKTVLQGLEALRVEHVSIMNGIAEVQK------DNEKSDMLRKNIENIELGLSEA 61
            ::|||||:..||.|:||||.||.||.:::..:|..:.      ..|:..:||:::|.|||||.||
Mouse    11 KLSQDEIVLGTKAVIQGLETLRGEHRALLAPLASHEAGEAEPGSQERCLLLRRSLEAIELGLGEA 75

  Fly    62 QVMMALTSHLQNIEAEKHKLKTQVRRLHQENAWLRDELANTQQKFQASEQLVAQLEEEKKHLEFM 126
            ||::||:|||..:|:||.||:.|||||.|||.|||:|||.||||.|.|||.||||||||:||.||
Mouse    76 QVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREELAGTQQKLQRSEQAVAQLEEEKQHLLFM 140

  Fly   127 ASVKKYDE----NQEQDDACDKSRTDPVVELFPDEENEDRHNMSPTP-PSQFANQTSGYEIPARL 186
            :.::|.||    |:|:.|.    ..|.:.:|||   |||..:.:|:| ....|.|..||||||||
Mouse   141 SQIRKLDEDASPNEEKGDV----PKDSLDDLFP---NEDEQSPAPSPGGGDVAAQHGGYEIPARL 198

  Fly   187 RTLHNLVIQYASQGRYEVAVPLCKQALEDLERTSGHDHPDVATMLNILALVYRDQNKYKEAANLL 251
            |||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||:||:||
Mouse   199 RTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAAHLL 263

  Fly   252 NDALSIRGKTLGENHPAVAATLNNLAVLYGKRGKYKDAEPLCKRALEIREKVLGKDHPDVAKQLN 316
            ||||:||.||||::||||||||||||||||||||||:||||||||||||||||||.||||||||:
Mouse   264 NDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLS 328

  Fly   317 NLALLCQNQGKYDEVEKYYQRALDIYESKLGPDDPNVAKTKNNLAGCYLKQGRYTEAEILYKQVL 381
            |||||||||||.:|||.||:|||:||.::||||||||||||||||.||||||:|.:||.|||::|
Mouse   329 NLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEIL 393

  Fly   382 TRAHEREFGAIDSK-----------------NKPIWQVAEEREEHKFDNRENTPYGEYGGWHKAA 429
            |||||:|||:::::                 |||||..||||||.|...|::.||||||.|:||.
Mouse   394 TRAHEKEFGSVNARLERSVWQAGDSPSLLGENKPIWMHAEEREESKDKRRDSAPYGEYGSWYKAC 458

  Fly   430 KVDSPTVTTTLKNLGALYRRQGMFEAAETLEDCAMRSKKEAYDLAKQTKLSQLLTS-----NEKR 489
            |||||||.|||::|||||||||..|||.||||||.||:|:..|.|.|||:.:||..     ..:|
Mouse   459 KVDSPTVNTTLRSLGALYRRQGKLEAAHTLEDCASRSRKQGLDPASQTKVVELLKDGSGGRGHRR 523

  Fly   490 RSKAI-----KEDLDFS 501
            .|:.:     :.||:.|
Mouse   524 GSRDVAGPQSESDLEES 540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KlcNP_524049.1 TPR 183..>391 CDD:440225 181/207 (87%)
TPR repeat 187..214 CDD:276809 26/26 (100%)
TPR repeat 228..256 CDD:276809 25/27 (93%)
TPR repeat 270..298 CDD:276809 26/27 (96%)
TPR repeat 311..341 CDD:276809 24/29 (83%)
TPR repeat 354..381 CDD:276809 20/26 (77%)
Klc2NP_001356290.1 Crescentin 26..>132 CDD:437057 58/105 (55%)
TPR 195..437 CDD:440225 191/241 (79%)
TPR repeat 199..226 CDD:276809 26/26 (100%)
TPR repeat 240..268 CDD:276809 25/27 (93%)
TPR repeat 282..310 CDD:276809 26/27 (96%)
TPR repeat 323..353 CDD:276809 24/29 (83%)
TPR repeat 366..393 CDD:276809 20/26 (77%)

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