DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp69D and PTPRZ1

DIOPT Version :9

Sequence 1:NP_524048.2 Gene:Ptp69D / 39443 FlyBaseID:FBgn0014007 Length:1462 Species:Drosophila melanogaster
Sequence 2:NP_002842.2 Gene:PTPRZ1 / 5803 HGNCID:9685 Length:2315 Species:Homo sapiens


Alignment Length:1458 Identity:367/1458 - (25%)
Similarity:590/1458 - (40%) Gaps:349/1458 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   170 KWLKDGSQFEFL--DTFSSISKLNDTHLNFTLEFTEVYKKENGTYKCTVFDDTGLEITSKEITL- 231
            :|....|..|||  || ..::.||.:......||         ||..:||.|....::..||.. 
Human   995 EWSGASSDSEFLLPDT-DGLTALNISSPVSVAEF---------TYTTSVFGDDNKALSKSEIIYG 1049

  Fly   232 --FVMEVPQVSIDFAKAVGANKIYLNWTVNDGN--DPIQKFFITLQEAGTPTFTYHKDFINGS-- 290
              ..:::|..:         ..:|.:.:....|  |.:.|...:|||... :.:..|....||  
Human  1050 NETELQIPSFN---------EMVYPSESTVMPNMYDNVNKLNASLQETSV-SISSTKGMFPGSLA 1104

  Fly   291 H-TSYILDHFKPNTTYFLRIVGKNSIGNGQPTQYPQGITTLSYDPIFIPKVETTGSTASTITIGW 354
            | |:.:.||       .:..|.:|:. :.|||   ..::..|.|....|.:......||:     
Human  1105 HTTTKVFDH-------EISQVPENNF-SVQPT---HTVSQASGDTSLKPVLSANSEPASS----- 1153

  Fly   355 NPPPPDLID---YIQYYELIVSESGEV-------------------PKVIEEAIYQQNSRNLPYM 397
            :|...:::.   .:.:||...|.|.||                   |.|..:.|..:..:     
Human  1154 DPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDTLLKTVLPAVPSDPILVETPK----- 1213

  Fly   398 FDKLKT---------ATDYEFRVRACS----DLTKTCGPWSENVNGTTMDGVATK--PTNLSIQC 447
            .||:.:         :...|..:.:.|    |::.|....|.::.|.|:...:.|  |..|..:.
Human  1214 VDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGLTISYASEKYEPVLLKSES 1278

  Fly   448 HH---------DNVTRGNSIAINWDVPKTPNGKVVSYLIHLLGNPMSTVDREMWGPKIRRIDEPH 503
            .|         |.:.:..::.||...|  |.|:      |:...|            :..||||.
Human  1279 SHQVVPSLYSNDELFQTANLEINQAHP--PKGR------HVFATP------------VLSIDEPL 1323

  Fly   504 HKTLYESVSPNTNYTVTVSAITRHKKNGEPATGSCLMPVSTPDAI----GRTMWSKVNLDSKYVL 564
            :..:.:.:..:...|.|.|::|.....|.|...|... |||..::    |....:.|:       
Human  1324 NTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTF-VSTDHSVPIGNGHVAITAVS------- 1380

  Fly   565 KLYLPKISERNGPICCYRLYLVRINNDNKELPDPEKLNIATYQEVHSDNVTRSSAYIAEMISSKY 629
                   ..|:|.:...:|..            |.|   ||.:..||   .:|.|.:......  
Human  1381 -------PHRDGSVTSTKLLF------------PSK---ATSELSHS---AKSDAGLVGGGED-- 1418

  Fly   630 FRPEIFLGDEKRFSENNDIIRDNDEI-CRKCLEGTPFLRKPEIIHIPPQGSLSNSDSELPILSEK 693
                   ||.....:::|..|.:|.: ..||:..:.:....|.:       :::||:....|.::
Human  1419 -------GDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEKV-------MNDSDTHENSLMDQ 1469

  Fly   694 DNLIKGANLTEHALKILESKLRDKRNAVTS------------------------------DENPI 728
            :|.| ..:|:|::         ::.|.|||                              :||.|
Human  1470 NNPI-SYSLSENS---------EEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQKHNDGKEENDI 1524

  Fly   729 L--SAVNPNVP--------LHDSSRDVFDGEID-INSNYT----GFLEIIVRDRNNALMAYSKYF 778
            .  ||:.|..|        ..|.......|..| :|.|.|    .|.:...:|.:..|.|.... 
Human  1525 QTGSALLPLSPESKAWAVLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSE- 1588

  Fly   779 DIITPATEAEPIQSL---------------NNMDYYLSIGVKAG------AVLLGVI---LVFIV 819
              |||.....|..|:               :|..:...||:..|      ||:..||   |.||.
Human  1589 --ITPGFPQSPTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFIC 1651

  Fly   820 LWVFHHKKTKNELQGEDTLTLRDSLSRALFGRRNHNHSHFITSGNHK--------------GFDA 870
            |.|.                    :...::.|:....:||....:..              ..|.
Human  1652 LVVL--------------------VGILIYWRKCFQTAHFYLEDSTSPRVISTPPTPIFPISDDV 1696

  Fly   871 G-------PIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSD---------RTTKNSDLKENAC 919
            |       |.|..||       |..:  ||..|:|.|...:.:         .|..:|:..:|..
Human  1697 GAIPIKHFPKHVADL-------HASS--GFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKH 1752

  Fly   920 KNRYPDIKAYDQTRVKLAVI---NGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIW 981
            ||||.:|.|||.:|||||.:   :| :.|||||||:|.||...|.:|.||||::||.:|||||||
Human  1753 KNRYINIVAYDHSRVKLAQLAEKDG-KLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIW 1816

  Fly   982 EQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANV 1046
            |.::|:|||:|||.|..:.||.:|||..  .::::|:.||.....:....|..|...:...|...
Human  1817 EHNVEVIVMITNLVEKGRRKCDQYWPAD--GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKK 1879

  Fly  1047 GEEEDR---RQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQR--GPILVHCSAGVGRTGT 1106
            |.::.|   |.:|||||..|.|...||:...::.|:|:  :.|:.:.  ||::||||||||||||
Human  1880 GSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRK--AAYAKRHAVGPVVVHCSAGVGRTGT 1942

  Fly  1107 LVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMAS 1171
            .:.|||::||::.|.:|:|:..:..:|.|||:|||:.:||:|::..|::......|::....:.:
Human  1943 YIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHA 2007

  Fly  1172 AIESLKRKPNEGKCKLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLP 1236
            .:.:|......||.|||.:|: ||:.::......|....:.|..|||:..|||.:|:||.::.| 
Human  2008 YVNALLIPGPAGKTKLEKQFQ-LLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSL- 2070

  Fly  1237 MRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPRKCPR-- 1299
            ..|.:.|||||:|.||..|..|||.|.||.:||.||||||.:.:...:|||.   ||......  
Human  2071 SGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIP---DGQNMAEDEF 2132

  Fly  1300 -YW--ADDEVQYDHILVKYVHSE-SCPYYTRR----EFYVTNCKIDDTLKVTQFQYNGWPTVDGE 1356
             ||  .|:.:..:...|..:..| .|.....:    :|.:...:.|..|:|..||...||..|..
Human  2133 VYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP 2197

  Fly  1357 VPEVCRGIIELVDQAYNHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICA 1421
            :.:....|..:.::|.|.         ..|:.||...|...:..|.|:..|:..|..|..||:..
Human  2198 ISKTFELISVIKEEAANR---------DGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQ 2253

  Fly  1422 TTRKLRSQRTGLINSYAQYEFLHRAIIN 1449
            ..:.:...|.|:.....||:||::.|::
Human  2254 VAKMINLMRPGVFADIEQYQFLYKVILS 2281

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp69DNP_524048.2 IG_like 139..233 CDD:214653 18/67 (27%)
Ig 150..221 CDD:143165 16/52 (31%)
fn3 237..321 CDD:278470 18/88 (20%)
FN3 339..432 CDD:238020 20/127 (16%)
FN3 439..535 CDD:238020 22/106 (21%)
PTPc 892..1155 CDD:214550 115/279 (41%)
PTPc 920..1155 CDD:238006 107/242 (44%)
PHA02694 <1121..1206 CDD:177476 23/84 (27%)
PTPc 1186..1449 CDD:214550 83/272 (31%)
PTPc 1216..1449 CDD:238006 75/242 (31%)
PTPRZ1NP_002842.2 PARM 1089..>1255 CDD:293666 33/187 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1123..1160 9/45 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1397..1523 27/157 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1543..1572 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1584..1621 7/39 (18%)
PTPc 1716..1991 CDD:214550 115/279 (41%)
PTPc 1752..1991 CDD:238006 107/243 (44%)
Substrate binding. /evidence=ECO:0000250 1933..1939 5/5 (100%)
PTPc 2022..2280 CDD:214550 82/271 (30%)
PTPc 2050..2280 CDD:238006 74/242 (31%)
alpha_CARP_receptor_like 45..298 CDD:239396
fn3 313..401 CDD:278470
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 442..462
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..507
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 628..650
MFMR 684..>763 CDD:285072
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR19134
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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