DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp69D and PTPRS

DIOPT Version :9

Sequence 1:NP_524048.2 Gene:Ptp69D / 39443 FlyBaseID:FBgn0014007 Length:1462 Species:Drosophila melanogaster
Sequence 2:NP_002841.3 Gene:PTPRS / 5802 HGNCID:9681 Length:1948 Species:Homo sapiens


Alignment Length:1835 Identity:430/1835 - (23%)
Similarity:698/1835 - (38%) Gaps:576/1835 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 GKNVSLEC---ASENEAVAWKLGNQTINKNHTRYKIRTEPLKSNDDGSENNDSQDFIKYKNVLAL 99
            |.||::.|   .|....|.|..|              .|.|...||....         :|||.|
Human   259 GGNVNITCVAVGSPMPYVKWMQG--------------AEDLTPEDDMPVG---------RNVLEL 300

  Fly   100 LDVNIKDSGNYTCTAQTGQ---NHSTEFQVR--PYLPS--KVLQST------------PDRI--- 142
            .||  |||.||||.|.:..   ....:..|:  |..|.  .|.::|            ||.:   
Human   301 TDV--KDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYY 363

  Fly   143 ----KRK-------IKQDVMLYCLIEMYPQNETTNRNLKWLKDGSQFE-FLDTFSSISKLNDTHL 195
                |.|       ||:|:            .||..::..|...|::| ::...:||.:      
Human   364 VIEYKSKSQDGPYQIKEDI------------TTTRYSIGGLSPNSEYEIWVSAVNSIGQ------ 410

  Fly   196 NFTLEFTEVYKKENGTYKCTVFDDTGLEITS---KEITLFVMEVPQVSIDFAKAVGAN------K 251
                          |....:|...||.:..:   :.:...::....:.:.:.:.|..|      :
Human   411 --------------GPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYR 461

  Fly   252 IYL---------NW------------------------------TVNDG--NDPIQ--------- 266
            :|.         ||                              :|.||  :||||         
Human   462 VYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPG 526

  Fly   267 -----------KFFITL------QEAGTPTFTYHKDFINGSH-----------TSYILDHFKPNT 303
                       :..|||      ||:   ...|...|..|.|           |||:::..||||
Human   527 QPMNLRAEARSETSITLSWSPPRQES---IIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNT 588

  Fly   304 TYFLRIVGKNSIGNGQPTQYPQGI---------TTLSYDPIFIPK-VETTGSTASTITIGWNPPP 358
            .|..|:..::          |||:         .||...|...|: |:.....::.|.:.|.|||
Human   589 EYAFRLAARS----------PQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPP 643

  Fly   359 PD-----LIDYIQYYELIVSESGEVPKVIEEAIYQQNSRNLP-----YMFDKLKTATDYEFRVRA 413
            |:     |:.|...|..:.||..| ||.:         ..:|     .:.:.|:..|.|.....|
Human   644 PETHNGALVGYSVRYRPLGSEDPE-PKEV---------NGIPPTTTQILLEALEKWTQYRITTVA 698

  Fly   414 CSDLTKTCGPWSENVNGTTMDGVATKPTNLSIQCHHDNVTRGNSIAINW--DVPKTPNGKVVSYL 476
            .:::..  ||.|..|...|.:.|.:.|.. .::....|.|   :|.:.|  ..|...:|::..|.
Human   699 HTEVGP--GPESSPVVVRTDEDVPSAPPR-KVEAEALNAT---AIRVLWRSPAPGRQHGQIRGYQ 757

  Fly   477 IHLLGNPMSTVDREMWG------PKIRRI----------DEPHHKTLYESVSPNTNYTVTVSAIT 525
            :|.:         .|.|      |:|:.:          |...::.:..::.|.|.|::||:|.|
Human   758 VHYV---------RMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYT 813

  Fly   526 RHKKNG----------------------------------EPATGSC---------------LMP 541
            . |.:|                                  ||..|:.               ..|
Human   814 M-KGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTP 877

  Fly   542 VST---PDAIGRTMWSKVNLDSKYVLKL------------------------------------- 566
            ::|   |.:..|...|.|:..:.||.:|                                     
Human   878 LATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNAS 942

  Fly   567 -------YLPKI-SERNGPICCYRLYLVRINN-------DNKELP---DPEKLNIATYQEVHSDN 613
                   :||.: :||||.|.   .|.|.:..       ...|||   :|...|..|.|.:..|.
Human   943 AGTVLLRWLPPVPAERNGAIV---KYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDT 1004

  Fly   614 V-------------------TRSSAYIAEMISSKYFRPEIFLGDEK----RFSEN---------- 645
            .                   .|...::.:.:|.|.|:.::.:....    .|.:|          
Human  1005 AYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQ 1069

  Fly   646 -NDIIRDNDEICRK-------------------------------------CLEGTPFLR-KPE- 670
             |.:..|.|....|                                     .|.|.|.:. ||: 
Human  1070 YNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDA 1134

  Fly   671 ---------------------IIHIP-----------PQGSLSNSDSELPILSEKDNLIKGANLT 703
                                 |:.:|           |.||..:.|.|              .|.
Human  1135 DGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLE--------------ELI 1185

  Fly   704 EHALKILESKLRDKRNAVTSDENPILSAVNPNVP--LHDSSRDVFDG----EIDINSNYTGFLEI 762
            :...::....||..|....  ..|.::|....:|  .|...:..:.|    .::....|..|: :
Human  1186 QDISRLQRRSLRHSRQLEV--PRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFV-L 1247

  Fly   763 IVRDRNNALMAYSKYFDIITPATEAEPIQSLNNMDYYLSIGVKAGAV-LLGVIL--VFIVLWVF- 823
            .|..::....|.|.:.|         |.| |:|.|....:..:.|.: ::|.:|  |||:..|. 
Human  1248 AVLQKSEPTFAASPFSD---------PFQ-LDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIA 1302

  Fly   824 ------------------------------HHKKTKNELQGEDTLT----LRDSLSRALFGRRNH 854
                                          ||.|...|::..:..|    ||..|....|     
Human  1303 ILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGF----- 1362

  Fly   855 NHSHFITSGNHKGFDAGPIHRLDLENAYKNRHKDTDYGFLREYEML-PNRFSDRTTKNSDLKENA 918
               ||.:..:|.     ||...|:....:....:......:|||.: |.:  ..|.::|:|:.|.
Human  1363 ---HFESMLSHP-----PIPIADMAEHTERLKANDSLKLSQEYESIDPGQ--QFTWEHSNLEVNK 1417

  Fly   919 CKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQ 983
            .||||.::.|||.:||.|..|.|:..:||||||:|.||:.:..:|..|||:..|..|||||:|||
Human  1418 PKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQ 1482

  Fly   984 HLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGE 1048
            ....|||:|.|||.::.||.:|||.:  .|:.:|.|.|......:...:..||.::.||.::   
Human  1483 RSATIVMMTRLEEKSRIKCDQYWPNR--GTETYGFIQVTLLDTIELATFCVRTFSLHKNGSS--- 1542

  Fly  1049 EEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSL 1113
              ::|::.|:.:..|.|...||:|...:.|:|::.:......|||:|||||||||||..:.:|::
Human  1543 --EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAM 1605

  Fly  1114 IQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKR 1178
            :::::.|.:|.:|..|..:|.|||::||:..||.|::.|||:....|||::...::.:.|:.|.:
Human  1606 LERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQ 1670

  Fly  1179 -KPNEGKCKLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENST 1242
             :|.|....:|:||::|..:....|:..| .....|..|||...|:||:..||.|.|:...|.|.
Human  1671 VEPGEHVTGMELEFKRLANSKAHTSRFIS-ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSD 1734

  Fly  1243 YINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYW-ADDE 1305
            |||||||:||...:.:|..|.||..|..|||||:.|.:.|.:||::::.: |..||.:|| |:..
Human  1735 YINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERS 1799

  Fly  1306 VQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQ 1370
            .:|.:.:|..:...:.|.|..|||.||:.:...:..|.|||:..||  :..||:...|.|:.:.|
Human  1800 ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWP--EQGVPKSGEGFIDFIGQ 1862

  Fly  1371 AYNHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLIN 1435
            .   :|..:..|...|::||||.|..|:.:|:.:.|:::.:|.|..|||..|.:.||:||..::.
Human  1863 V---HKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQ 1924

  Fly  1436 SYAQYEFLHRAIINY 1450
            :..:|:|.::|.:.|
Human  1925 TEDEYQFCYQAALEY 1939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp69DNP_524048.2 IG_like 139..233 CDD:214653 18/111 (16%)
Ig 150..221 CDD:143165 9/71 (13%)
fn3 237..321 CDD:278470 30/167 (18%)
FN3 339..432 CDD:238020 24/103 (23%)
FN3 439..535 CDD:238020 25/147 (17%)
PTPc 892..1155 CDD:214550 101/263 (38%)
PTPc 920..1155 CDD:238006 93/234 (40%)
PHA02694 <1121..1206 CDD:177476 27/85 (32%)
PTPc 1186..1449 CDD:214550 92/264 (35%)
PTPc 1216..1449 CDD:238006 85/234 (36%)
PTPRSNP_002841.3 Ig 32..120 CDD:299845
I-set 33..124 CDD:254352
Important for binding to glycosaminoglycan chains. /evidence=ECO:0000250|UniProtKB:B0V2N1 68..72
IG_like 141..234 CDD:214653
Ig2_RPTP_IIa_LAR_like 152..235 CDD:143215
IG_like 251..328 CDD:214653 26/93 (28%)
Ig3_RPTP_IIa_LAR_like 259..327 CDD:143216 26/92 (28%)
FN3 332..421 CDD:238020 20/120 (17%)
FN3 428..520 CDD:238020 12/91 (13%)
FN3 525..613 CDD:238020 21/100 (21%)
FN3 621..715 CDD:238020 25/105 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 700..724 6/25 (24%)
FN3 723..828 CDD:238020 23/118 (19%)
FN3 838..920 CDD:238020 12/81 (15%)
FN3 932..1029 CDD:238020 18/99 (18%)
FN3 1037..>1097 CDD:238020 8/59 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1311..1340 3/28 (11%)
PTPc 1392..1647 CDD:214550 101/263 (38%)
PTPc 1418..1647 CDD:238006 93/235 (40%)
Substrate binding. /evidence=ECO:0000250 1589..1595 5/5 (100%)
PTPc 1679..1938 CDD:214550 92/264 (35%)
PTPc 1708..1938 CDD:238006 85/234 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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