DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp69D and PTPRM

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_011524010.1	Gene:	PTPRM / 5797	HGNCID:	9675	Length:	1507	Species:	Homo sapiens

Alignment Length:	1494	Identity:	372/1494 - (24%)
Similarity:	607/1494 - (40%)	Gaps:	311/1494 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 FIKYKNVLALLDVNIKDSGNYTCTAQTGQNHSTEFQVRPYLPSKVLQSTPDRIKRKIKQDVMLYC 154
            |::.:||    :||......:.|:|                           |.|.:..|
Human   188 FLRIQNV----EVNAGQFATFQCSA---------------------------IGRTVAGD----- 216

  Fly   155 LIEMYPQN-ETTNRNLKWLKDGSQFEFLDTFSSISKLNDTHLNFTLEFTEVYKKENGTYKCTVFD 218
              .::.|. :..:..||.:|..|...|:.:|:.:   |.|            |::.|.|:|.:..
Human   217 --RLWLQGIDVRDAPLKEIKVTSSRRFIASFNVV---NTT------------KRDAGKYRCMIRT 264

  Fly   219 DTGLEITSKEITLFVMEVP-QVSIDFAKAVGANKIYLNWTVN--DGNDPIQKFFITLQEAGTPTF 280
            :.|:.| |....|.|.|.| .::.....:|||..:::....|  :|:.|     |..:|....|
Human   265 EGGVGI-SNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP-----IVAREVEYCT- 322

  Fly   281 TYHKDFINGS--------HTSYILDHFKPNTTYFLRIV----GKNSIGNGQPTQYPQGITTLSYD 333
                  .:||        .|||.:.|..|:|.|.:.::    |:...|:..|....:   |...|
Human   323 ------ASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTR---TKCAD 378

  Fly   334 PIFIP-KVETTGSTASTITIGWNPPPPDLIDY----IQYYELIVS---ESGEVPKVIEEAIYQ-Q 389
            |:..| |:|.....:..|||.|.|     ..|    ...|.|.|.   :.|...:|.||..:. :
Human   379 PMRGPRKLEVVEVKSRQITIRWEP-----FGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTE 438

  Fly   390 NSR------NL-PYMFDKLK--------TATDYEFRVRACSDLTKTCGPWSENVNGTTMDGVATK 439
            ||.      || ||....:|        .....|..|:...||.....  :|::.|:|.:
Human   439 NSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVP--TESIQGSTFE----- 496

  Fly   440 PTNLSIQCHHDNVTRGNSIAINWDVPKTPNGKVVSYLIHLLGNPMSTVDREM----WGPKIRRID 500
                            ..|.:.|..|....|.:..|  .:....:|:.|.|:    ...::.::.
Human   497 ----------------EKIFLQWREPTQTYGVITLY--EITYKAVSSFDPEIDLSNQSGRVSKLG 543

  Fly   501 EPHHKTLYESVSPNTNYTVTVSAITRHKKNGEPATGSCLMPVSTPDAIGRTMWSKVNLDSKYVLK 565
            ...| .|:..:.|.|.|:.|:.|.|. |..|.|||......:|.|......:.:.:|.....|..
Human   544 NETH-FLFFGLYPGTTYSFTIRASTA-KGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTV 606

  Fly   566 LYLPKISERNGPICCYRLYLVRINNDNKELPDPEKLNIATYQ----EVHSDNVTRSSAYIAEMIS 626
            :..|..| |..|:..|::.:      .:|.|...|......:    .:|..|        |.:::
Human   607 MLKPAHS-RGAPVSVYQIVV------EEERPRRTKKTTEILKCYPVPIHFQN--------ASLLN 656

  Fly   627 SKYFRPEIF------------LGDEKRFSE--NNDII-------------RDNDEICRKCLE--- 661
            |:|:....|            :||.|.::.  |..::             |.|.|....|::
Human   657 SQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVAT 721

  Fly   662 ---------GTPFLRKPEIIHIPP---QGSLSNSDSELPILS-EKDNLIKGANLTEHALKI---- 709
                     .||::|      |.|   .|.|:.:.:..|:.. ||.        |:|.:||
Human   722 KAAIIVTQLTTPYIR------IAPAAGDGQLTGAATPKPVPEPEKQ--------TDHTVKIAGVI 772

  Fly   710 ----------LESKLRDKRNAVTSDENPILSAVNPNVPLHDSSRDVFDGEIDINSNYTGFLEIIV 764
                      |...|..|:..:.......:|:....:.:..:|.|....|...|.: ..|..:..
Human   773 AGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCD-EAFSFMDT 836

  Fly   765 RDRNNALMAYSKYFDIITPATEAEPIQSLNNMDYYLSIGVKAGAVLLGVILVFIVLWVFHHKKTK 829
            .:.|...::....|.:.|.....    |:.| .||....|.. |:|:.:
Human   837 HNLNGRSVSSPSSFTMKTNTLST----SVPN-SYYPDPFVPT-AILVPI---------------- 879

  Fly   830 NELQGEDTLTLRDSLSRALFGRRNHNHSHFITSGNHKGFDAGPIHR----LDLENAYKNRHKDTD 890
                .::|.|:....|..:     .:|::.........:..|.:|.    .||............
Human   880 ----NDETHTMASDTSSLV-----QSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEG 935

  Fly   891 YGFLREYEMLPNRFSDRTTKNSDLK--ENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFV 953
            |||..|||..   |..::......|  ||..||||.:|.|||.:||:|..|.|...:||||.|::
Human   936 YGFKEEYESF---FEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYI 997

  Fly   954 IGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGD 1018
            .||.....:|..||||:.||.|||||:|.::...|:|:|||.|..:.||.||||:   ||:.:.|
Human   998 DGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD---DTEIYKD 1059

  Fly  1019 ILVKFAQERKTGDYIERTLNVSKNKANVGEE-------------EDRRQITQYHYLTWKDFMAPE 1070
            |.|...:.....:|:.||..|.|..|. ||.             .:.|:|.|:|:..|.|...|.
Human  1060 IKVTLIETELLAEYVIRTFAVEKGGAG-GEANCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPY 1123

  Fly  1071 HPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQ 1135
            |..|::.|:||:.|......||::||||||.||||..:.:|.::...|.|..|.|||.|.:||.:
Human  1124 HATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSR 1188

  Fly  1136 RNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESL-----KRKPNEGKCKLEVEFEKL- 1194
            |..:||:.:||:|::.|:|:....|:|.:    .||.:.||     |..|.....:::.||..|
Human  1189 RVNMVQTEEQYVFIHDAILEACLCGDTSV----PASQVRSLYYDMNKLDPQTNSSQIKEEFRTLN 1249

  Fly  1195 LATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFI 1259
            :.|.....:.||:.....|:.|||..:|:|.||....|..:. .|:|.||||:.::.|.....||
Human  1250 MVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITID-GESSNYINAALMDSYKQPSAFI 1313

  Fly  1260 IAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPRKCPRYWADDEV-QYDHILVKYVHSESCPY 1323
            :.|.||.||:.||||::.:...|::||:::: |..:.||:||.::.| ::..|.|::|.::....
Human  1314 VTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV-DPAQLCPQYWPENGVHRHGPIQVEFVSADLEED 1377

  Fly  1324 YTRREFYVTNC--KIDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNSGCRSP 1386
            ...|.|.:.|.  ..|....|.|||:.||| :..:.|...|..::|:.|. :.::...|.| ...
Human  1378 IISRIFRIYNAARPQDGYRMVQQFQFLGWP-MYRDTPVSKRSFLKLIRQV-DKWQEEYNGG-EGR 1439

  Fly  1387 LTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY 1450
            ..|||..|..||..|.|:.|:.:.||.::.||:....:.||:.:..:::...||:|.:...:.|
Human  1440 TVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY 1503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653	20/94 (21%)
		Ig	150..221	CDD:143165	13/71 (18%)
		fn3	237..321	CDD:278470	21/98 (21%)
		FN3	339..432	CDD:238020	28/115 (24%)
		FN3	439..535	CDD:238020	19/99 (19%)
		PTPc	892..1155	CDD:214550	109/277 (39%)
		PTPc	920..1155	CDD:238006	100/247 (40%)
		PHA02694	<1121..1206	CDD:177476	27/90 (30%)
		PTPc	1186..1449	CDD:214550	80/266 (30%)
		PTPc	1216..1449	CDD:238006	73/235 (31%)
PTPRM	XP_011524010.1	MAM	22..182	CDD:214533
		MAM	27..182	CDD:99706
		IG_like	192..278	CDD:214653	26/139 (19%)
		ig	192..274	CDD:278476	25/135 (19%)
		FN3	282..361	CDD:214495	20/90 (22%)
		FN3	383..477	CDD:238020	25/98 (26%)
		FN3	499..581	CDD:238020	21/85 (25%)
		PTPc	937..1208	CDD:214550	109/277 (39%)
		PTPc	964..1208	CDD:238006	100/247 (40%)
		PTPc	1240..1502	CDD:214550	80/266 (30%)
		PTPc	1270..1502	CDD:238006	73/236 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810