DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp69D and PTPRK

DIOPT Version :9

Sequence 1:NP_524048.2 Gene:Ptp69D / 39443 FlyBaseID:FBgn0014007 Length:1462 Species:Drosophila melanogaster
Sequence 2:NP_001278910.1 Gene:PTPRK / 5796 HGNCID:9674 Length:1462 Species:Homo sapiens


Alignment Length:1449 Identity:362/1449 - (24%)
Similarity:579/1449 - (39%) Gaps:359/1449 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   161 QNET-----TNR----NLKWL--KDGSQFEFLDTFSSISKLNDTHLNFTLEF--TEVYKKENGTY 212
            ||.|     |.|    |..||  ::|.......|      .|..|..|...|  .||.|.:...|
Human   210 QNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQT------KNINHRRFAASFRLQEVTKTDQDLY 268

  Fly   213 KCTVFDDTGLEITSKEITLFVMEVPQVSIDFAKAVGANKIYL------NWTVNDGNDPIQKFFIT 271
            :|....:.|..: |....|.|.|.|: .|...:.:|....||      |..:.||.       |.
Human   269 RCVTQSERGSGV-SNFAQLIVREPPR-PIAPPQLLGVGPTYLLIQLNANSIIGDGP-------II 324

  Fly   272 LQE------AGTPTFTYHKDFINGSHTSYILDHFKPNTTYFLRIV----GKNSIGNGQPTQYPQG 326
            |:|      :|:.|.|:   .:|.  .:|.|.|..|:|.|.:|::    |:.  |.|.|.  |..
Human   325 LKEVEYRMTSGSWTETH---AVNA--PTYKLWHLDPDTEYEIRVLLTRPGEG--GTGLPG--PPL 380

  Fly   327 IT-TLSYDPIFIPKV---------------ETTGSTAS-----TITI------GWNPPPPDLIDY 364
            || |...:|:..||.               |:.|...:     .:||      |.|....|.:|.
Human   381 ITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDM 445

  Fly   365 IQYYELIVSESGEVPKVIEEAIYQQNSRNLPYMFDKLK-TATDYEFRVRACSDLTKTCGPWSENV 428
                         .||..:..:    :...||....|| ..|:.|.|..:...:.:|    .|:|
Human   446 -------------DPKAPQHVV----NHLPPYTNVSLKMILTNPEGRKESEETIIQT----DEDV 489

  Fly   429 NGTTMDGVATKPTNLSIQCHHDNVTRGNSIAINWDVPKTPNGKVVSYLIHL-----------LGN 482
            .|.    |..|    |:|    ..:..|.|.:||..|..|||.:..|.|..           :..
Human   490 PGP----VPVK----SLQ----GTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAG 542

  Fly   483 PMSTVDREMWGPKIRRIDEPHHKTLYESVSPNTNYTVTVSAITRHKKNGEPATGSCLMPVST--- 544
            |..||. .:|       :..||  ::..:.|.|.|...:.|.|  .|...|||.   :.|:|   
Human   543 PPQTVS-NLW-------NSTHH--VFMHLHPGTTYQFFIRAST--VKGFGPATA---INVTTNIS 592

  Fly   545 ----PDAIGRTMWSKVNLDSKYVLKLYLPKISERNGPICCYRLYLVRI--NNDNKELPDPEKLNI 603
                ||..|  :.:.:| ::...:.:.|.....:..||..|::.:..:  :...:|....|...:
Human   593 APTLPDYEG--VDASLN-ETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQV 654

  Fly   604 -ATYQEVHSDNVTRSSAYIAEMISSKYFRPEIF-LGDEKRFSENNDIIRDNDEICRKCLEGTPFL 666
             .|||...|...  ...:.||:.......|..| :||.:.:                        
Human   655 PVTYQNAMSGGA--PYYFAAELPPGNLPEPAPFTVGDNRTY------------------------ 693

  Fly   667 RKPEIIHIPPQGSLSNSDSELPILSEKDNLIKGANLTEHALKILESK-----LRDKRNAVTSDEN 726
                      ||..:      |.|:.:    ||.|:...|:..:|.:     :|....|..::| 
Human   694 ----------QGFWN------PPLAPR----KGYNIYFQAMSSVEKETKTQCVRIATKAAATEE- 737

  Fly   727 PILSAVNPNVPLHDSSRDVFDGEIDINSNYTGFLEIIVRDRNNALMAYSKYFDIITPATEAEPIQ 791
                   |.|                                           |..||.:.:.:.
Human   738 -------PEV-------------------------------------------IPDPAKQTDRVV 752

  Fly   792 SLNNMDYYLSIGVKAGAVLLGVILVFIVLWVFHHKK-----------TKNEL-----------QG 834
            .:        .|:.|| :|:.::|:.:|:.:....|           |:.|:           ..
Human   753 KI--------AGISAG-ILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYAD 808

  Fly   835 EDTLTLRDSLSRALFGRRN---------------------HNHS------------HFITSGNHK 866
            :.||...|.||.....:.|                     .|||            .::..|...
Human   809 QSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLVPITDENHSATAESSRLLDVPRYLCEGTES 873

  Fly   867 GFDAGPIHR----LDLENAYKNRHKDTD-YGFLREYEMLPNRFSDRTTKNSDL---KENACKNRY 923
            .:..|.:|.    .||.. :.|..|.:| |||..|||    .|.:..:.:.|:   .:|..||||
Human   874 PYQTGQLHPAIRVADLLQ-HINLMKTSDSYGFKEEYE----SFFEGQSASWDVAKKDQNRAKNRY 933

  Fly   924 PDIKAYDQTRVKLAVINGLQTTDYINANFV------IGYKERKKFICAQGPMESTIDDFWRMIWE 982
            .:|.|||.:||.|..:....::||||||::      .||:....:|..|||:..|:.|||||||:
Human   934 GNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQ 998

  Fly   983 QHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVG 1047
            :....|||:|||.|..:.||.||||:   ||:.:||..|...:.....:|:.||..:.:...|  
Human   999 EQSACIVMVTNLVEVGRVKCYKYWPD---DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYN-- 1058

  Fly  1048 EEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDS 1112
               :.|::.|:|:..|.|...|.|..|::.|||::........|||:||||||.||||..:.:|.
Human  1059 ---EIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDI 1120

  Fly  1113 LIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICI-DTMASAIESL 1176
            ::...|.|..|.|||.|..||.:|..:||:.:||||::.|:|:....|.|.|.: :..|:..:.:
Human  1121 MLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMI 1185

  Fly  1177 KRKPNEGKCKLEVEFEKLLATADEI-SKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMREN 1240
            :.........|:.||:.|.:....: ::.||:.....|:.|||..:::|.||....|..:. .|:
Human  1186 RIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITID-GES 1249

  Fly  1241 STYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPRKCPRYWADD- 1304
            |.||||:.::.|.....||:.|.||.||:.||||::.:...|::||::|: |..:.||:||.:: 
Human  1250 SNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV-DLSQGCPQYWPEEG 1313

  Fly  1305 EVQYDHILVKYVH-SESCPYYTRREFYVTNC--KIDDTLKVTQFQYNGWPTVDGEVPEVCRGIIE 1366
            .::|..|.|:.:. |..|. ...|.|.:.|.  ..:..|.|.||||.||.: ..|||...|..::
Human  1314 MLRYGPIQVECMSCSMDCD-VINRIFRICNLTRPQEGYLMVQQFQYLGWAS-HREVPGSKRSFLK 1376

  Fly  1367 LVDQAYNHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRT 1431
            |:.|.....:..:....|:  .:||..|..||.:|.|:.|:|:.::.:..||:....:.||:.:.
Human  1377 LILQVEKWQEECEEGEGRT--IIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKP 1439

  Fly  1432 GLINSYAQYEFLHRAIINY 1450
            .::.:..||.|.:...:.|
Human  1440 NMVEAPEQYRFCYDVALEY 1458

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp69DNP_524048.2 IG_like 139..233 CDD:214653 22/84 (26%)
Ig 150..221 CDD:143165 19/72 (26%)
fn3 237..321 CDD:278470 25/99 (25%)
FN3 339..432 CDD:238020 22/119 (18%)
FN3 439..535 CDD:238020 26/106 (25%)
PTPc 892..1155 CDD:214550 103/271 (38%)
PTPc 920..1155 CDD:238006 95/240 (40%)
PHA02694 <1121..1206 CDD:177476 24/86 (28%)
PTPc 1186..1449 CDD:214550 80/267 (30%)
PTPc 1216..1449 CDD:238006 73/236 (31%)
PTPRKNP_001278910.1 MAM 32..192 CDD:214533
IG_like 202..288 CDD:214653 22/84 (26%)
fn3 297..371 CDD:365830 21/85 (25%)
fn3 488..581 CDD:365830 28/116 (24%)
PTP_DSP_cys 888..1166 CDD:391942 110/290 (38%)
Substrate binding. /evidence=ECO:0000250 1105..1111 4/5 (80%)
R-PTPc-K-2 1252..1457 CDD:350484 64/209 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4228
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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