DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp69D and PTPRC

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	NP_002829.3	Gene:	PTPRC / 5788	HGNCID:	9666	Length:	1306	Species:	Homo sapiens

Alignment Length:	1327	Identity:	370/1327 - (27%)
Similarity:	563/1327 - (42%)	Gaps:	323/1327 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 GQ-PTQYPQGITT-------LSYDPIFIPKVETTGSTASTI---------TIGWNPP------PP 359
            || ||..|.|:||       ||.||  :|...|..|.|||.         |...:|.      .|
Human    25 GQSPTPSPTGLTTAKMPSVPLSSDP--LPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSP 87

  Fly   360 DLIDYIQYYELIVSESGEVPKVIEEAIYQQNSRNLPYMFDKLKTATDYEFRVRACSDLTKTCGPW 424
            |.:|....:......|.:.|             :||       |..|.:         |.:.|..
Human    88 DSLDNASAFNTTGVSSVQTP-------------HLP-------THADSQ---------TPSAGTD 123

  Fly   425 SENVNGTTMDGVATKPTNLSIQCHHDNVTRGNSIAINWDVPKTPNGKVVSYLIHLLGNPMSTVDR 489
            ::..:|:.        .|..:     |.|.|:: ||: |||    |:         .:..||...
Human   124 TQTFSGSA--------ANAKL-----NPTPGSN-AIS-DVP----GE---------RSTASTFPT 160

  Fly   490 EMWGPKIRRIDEPHHKTLYESVSP--NTNYTVTVSAITRHKKNGEPAT----GSCLMPVSTPDAI 548
            :...|....:...||.:   :..|  .:|.|:|.:....:....|..|    ||.::..:|   |
Human   161 DPVSPLTTTLSLAHHSS---AALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTT---I 219

  Fly   549 GRTMWSKVNLDSKY----VLKLYLPKISERNGPICCYRLYLVRIN-NDNKELPDPEKLNIATYQE 608
            ..|. ||...|.||    |..||..:.          :|:..::| |:|.|..:    |..|..|
Human   220 ATTP-SKPTCDEKYANITVDYLYNKET----------KLFTAKLNVNENVECGN----NTCTNNE 269

  Fly   609 VH--------SDNVTRSSAYIAE---------------------------MISSKYFRPEIFLGD 638
            ||        |.:::.:|....:                           .|..|:...|.|..|
Human   270 VHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCD 334

  Fly   639 EK----RFSENNDIIRDNDEICRKCLE-----------------------------GTPFLRKPE 670
            .:    ||...| :|.||.||..:.||                             |:|  .:|:
Human   335 TQNITYRFQCGN-MIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSP--GEPQ 396

  Fly   671 IIHI-------------PPQGSLSN------SDSELPILSEKDNLIKG--ANLTEHALKILE--- 711
            ||..             |||.|..|      .::|...|:...||||.  .||..:...:|.
Human   397 IIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHA 461

  Fly   712 ------------------------SKLRDKRNAVTSDENPILSAVNP---NVPLHDSSRDVFDGE 749
                                    |::.:...::|||.:..:....|   |.|......:|..|.
Human   462 YIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGN 526

  Fly   750 IDINSNYTGFLEIIVRD-RNNALMAYSKYFDIITPATEAEPIQSLNNMDY------------YLS 801
            ..:.:......:..|:| :.:....:..||               :|.||            |.|
Human   527 TLVRNESHKNCDFRVKDLQYSTDYTFKAYF---------------HNGDYPGEPFILHHSTSYNS 576

  Fly   802 ---IGVKAGAVLLGVILVFIVLWVFH--HKKTKNELQGEDTLTLRDSLSRALFGRRNHNHSHFIT 861
               |...|..:::..|.:.:||:..:  |||....|..:..|..||...:.:
Human   577 KALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLM------------- 628

  Fly   862 SGNHKGFDAGPIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDI 926
                   :..|||...|...||.:..|....||.|::.:|..||....|.:....|..||||.||
Human   629 -------NVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 686

  Fly   927 KAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVML 991
            ..||..||:|:.|||...::||||:::.|:||.:|:|.||||.:.|:||||||||||...:|||:
Human   687 LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 751

  Fly   992 TNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQIT 1056
            |..||.|:.|||:|||.....|:.|||::||..|.::..|||.:.||:...|    |:...|::|
Human   752 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKK----EKATGREVT 812

  Fly  1057 QYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEED 1121
            ...:.:|.|...||.||.::|..|::|:..:...|||:||||||||||||.:.:|::::.||.|:
Human   813 HIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAEN 877

  Fly  1122 SVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESL-KRKPNEGKC 1185
            .|.:|..|..||.||..:||...|||.:::||::...||.|::.:..:...:.:: ||.|.....
Human   878 KVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPS 942

  Fly  1186 KLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILT-PLPM------------ 1237
            .||.||::|  .:....::..:|..|||..|||:..:||||.|||.|. .|.|
Human   943 PLEAEFQRL--PSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESS 1005

  Fly  1238 ------RENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPRK 1296
                  .|.|.|||||||..|...|..|.||.||:.||||||:||.::.|..:||::|:..|.::
Human  1006 DDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQE 1070

  Fly  1297 -CPRYWADDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPT--VDGEVP 1358
             |.:||.:.:..|..|.|....::....||.|.|.:.:.|..|:..|.|:||..|..  :..| |
Human  1071 ICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAE-P 1134

  Fly  1359 EVCRGIIELVDQAY---NHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDIC 1420
            :....:|::|.|..   |..:.||:.. .:||.:||..|:.::.||.|:..|::....|:.|||.
Human  1135 KELISMIQVVKQKLPQKNSSEGNKHHK-STPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIF 1198

  Fly  1421 ATTRKLRSQRTGLINSYAQYEFLHRAI 1447
            ...:.||..|.|:::::.||:||:..|
Human  1199 QVVKALRKARPGMVSTFEQYQFLYDVI 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653
		Ig	150..221	CDD:143165
		fn3	237..321	CDD:278470	2/3 (67%)
		FN3	339..432	CDD:238020	19/107 (18%)
		FN3	439..535	CDD:238020	20/97 (21%)
		PTPc	892..1155	CDD:214550	117/262 (45%)
		PTPc	920..1155	CDD:238006	109/234 (47%)
		PHA02694	<1121..1206	CDD:177476	25/85 (29%)
		PTPc	1186..1449	CDD:214550	98/287 (34%)
		PTPc	1216..1449	CDD:238006	89/257 (35%)
PTPRC	NP_002829.3	PTP_N	7..32	CDD:372119	4/6 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..163		42/193 (22%)
		PHA03255	81..>231	CDD:165513	41/213 (19%)
		CD45	237..295	CDD:372194	15/71 (21%)
		FN3	392..462	CDD:238020	18/71 (25%)
		FN3	485..565	CDD:238020	16/94 (17%)
		R-PTPc-C-1	707..907	CDD:350405	93/203 (46%)
		Substrate binding. /evidence=ECO:0000250	853..859		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	993..1014		1/20 (5%)
		R-PTP-C-2	1017..1223	CDD:350406	73/207 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1261..1306
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5448
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.720