DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp69D and ptprua

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_005159609.1	Gene:	ptprua / 563584	ZFINID:	ZDB-GENE-060503-232	Length:	1478	Species:	Danio rerio

Alignment Length:	1580	Identity:	347/1580 - (21%)
Similarity:	575/1580 - (36%)	Gaps:	382/1580 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RYKIRTEPLKSND-------------DGSENNDSQDFIKYKNVLALLDVNIKDSGNYTCT---AQ 115
            |.::...||..||             ||........:::         ||....||....   :|
Zfish    82 RAQLMLRPLSENDTHCVQFSYFLYSRDGHSPGGLNVYVR---------VNGGSRGNAVWNVSGSQ 137

  Fly   116 TGQNHSTEFQVRPYLPSK---VLQSTPDRIKRKIK-----QDVMLYCLIEMYP------------ 160
            ..|.|..|..|..:.||:   |.::|   |..:.|     .|::|.    .||
Zfish   138 GRQWHQVEMAVSTFWPSEYQIVFEAT---ISSEQKGYIGLDDIVLL----NYPCYKVPHFSRLGD 195

  Fly   161 ------QNET-----TNRNLK---WLKDGSQFEFLDTFSSISKLNDTHLNFTLEFTEVYKKENGT 211
                  ||.|     |.|::|   :|.:......:..:|..|.:.:..|....:.....:.|...
Zfish   196 VEVNAGQNATFQCVATGRSVKTDPFLMERRNGVLMAPYSVTSSIGERRLVAWFQVGGAQRGEQDL 260

  Fly   212 YKCTVFDDTGLEITSKEITLFVMEVPQVSIDFAKAVGANKIYL------NWTVNDGNDPIQKFFI 270
            |:|......|..:::  ....::.||...|...:.:.:...||      |..|.||  |:.:..|
Zfish   261 YRCITQSTFGAAVSN--FAELIVRVPPTPIAPPQLLRSGPTYLIIQLNTNSIVGDG--PVIRREI 321

  Fly   271 TLQEAGTPTFTYHKDFINGSHTSYILDHFKPNTTYFLRIV----GKNSIGNGQPTQYPQGITTLS 331
            ..:.:.:|....|.  :|.  .:|.:.|.:|:|.|.:.::    |:...|       |.|...:|
Zfish   322 VYRASHSPWSETHG--VNS--LTYKVWHLEPDTEYRISVLLTRPGEGGTG-------PPGPPLVS 375

  Fly   332 YDPIFIPKVETTGSTASTI-----TIGWNPPPPDLIDYIQY-----YELIVSESGEV---PKVIE 383
            ......|.....|.||:.|     .:.|.|...:|.....|     |....:..|..   ...:.
Zfish   376 RTKCAEPMRPLRGLTATEIQSRQLLLQWEPVGYNLTRCHTYSLSLCYRYSTATGGGAGGNNATVR 440

  Fly   384 EAI-YQQNS-----RNLPYMF-----------DKLKTATDYEFRVRACSDLTKTCGPWSENVNGT 431
            |.: .::|:     |:||...           :..|.:.:..|:.             .|::.|
Zfish   441 ECLSVERNTSRFTLRDLPPFHTVHVRLALANPEGKKESREVTFQT-------------EEDIPG- 491

  Fly   432 TMDGVATKPTNLSIQCHHDNVTRGNSIAINWDVPKTPNGKVVSYLIHLLGNPMSTVDREMWGPKI 496
               |:|  |.:|:.....|      .|.:.|:.|..|||.:..|.|.......|.....:.||:
Zfish   492 ---GIA--PESLTFTPLDD------MIFLKWEEPLEPNGLITQYEISYQSIESSDPSINVPGPR- 544

  Fly   497 RRIDEPHHKT--LYESVSPNTNYTVTVSAITRHKKNGEPATGSCLMPVSTPDAIGRTMWSKVNLD 559
            |.:.:..::|  ::..:.|.|.|.|:|.|.|. |..|:.|.......:|.|......:.|.::..
Zfish   545 RTVSKLKNETYHMFSGLHPGTTYLVSVRARTA-KGFGQTALTEITTNISAPAFDYEDVPSPLSES 608

  Fly   560 SKYVLKLYLPKISERNGPICCYRLYLVRINNDNKELPDPEKLNIATYQEVHSDNVTRSSA----- 619
            ...:..|..|.:. |..|:..|.:.:|. .:.::::...|..::..:....|...|...|
Zfish   609 ESTITVLLRPALG-RGAPVSTYHVVVVE-EDGSRQVRRRELGHMECFPAPSSHGETSGGAGGTPP 671

  Fly   620 --YIAEMISSKYFRPEIFLGDEKRFSENNDIIRDNDEICRKCLEGTPFLRKPEIIHIPPQGSLSN 682
              |.||:..|..  |                            |.|||
Zfish   672 HYYTAELSPSSL--P----------------------------EATPF----------------- 689

  Fly   683 SDSELPILSEKDNLIKGANLTEHALKILESKLRDKRNAVTSDENPILSAVNPNVPLHDSSRDV-- 745
                                                   |..:|...|.. .|.|| |.|::.
Zfish   690 ---------------------------------------TVGDNHTYSGY-WNTPL-DPSKNYLI 713

  Fly   746 -------FDGEIDINSNYTGFLEIIVRDRNNALMAYSKYFDIITPATEAEPIQSLNNMDYYLSIG 803
                   |.||..||..... .::..:|...||..          :..||        |..|.:|
Zfish   714 YFQASSNFRGETRINCIRIA-RKVACKDHKRALEV----------SQHAE--------DMGLILG 759

  Fly   804 VKAGA-----VLLGVILVFI---------------------VLWVFHHKKT------------KN 830
            ..||.     :|||.|:|.:                     .:..:..:||            .:
Zfish   760 ACAGGLVVLILLLGAIVVIVKKGRDIYSYPYYPRKKVNINKAVMTYRQEKTCKLGSLDCSTTEHS 824

  Fly   831 ELQGEDTL--TLRDS--------------LSRALFGRRNHNHSHFITSGNHKGFDAGPIHRLDLE 879
            .||.:|..  |..||              .|.:|.|.....|....:|..|.|.....:...||.
Zfish   825 TLQQDDRTAHTFLDSHNCTARNEQRSTVNESSSLLGGSPRRHCRRKSSPYHTGQLHPAVRVADLL 889

  Fly   880 NAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQT 944
            ...........|||.:|||    .|.|....|.  |::..|.|:..:...|:.|||:..:.....
Zfish   890 QHINQMKTGEGYGFKQEYE----SFFDGWDIND--KKDKTKGRHDTLLGQDRHRVKMHSLLADPN 948

  Fly   945 TDYINANFV------IGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCA 1003
            :||:|||::      .||:....||..|||.:..|.|||||:|:::...|||:|.|.|..:.||.
Zfish   949 SDYVNANYIDIRINREGYQRSNHFIATQGPKQDMIYDFWRMVWQENCYSIVMITKLVEVGRMKCC 1013

  Fly  1004 KYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFMA 1068
            ||||:   |::.:|||.:...:.....:|..||..:.:.....     :.::.|:|:.:|.:...
Zfish  1014 KYWPD---DSELYGDIKITLLKTETLAEYTVRTFAMERRGYPA-----KHEVCQFHFTSWPEHGV 1070

  Fly  1069 PEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLR 1133
            |.|..|::.|:|::.:......||::||||.|.||||..:.||.::...|.|..|.|||.|..|.
Zfish  1071 PYHATGLLAFLRRVKASTPPDAGPVVVHCSMGAGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLC 1135

  Fly  1134 HQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMA-SAIESLKRKPNEGKCKLEVEFEKLLAT 1197
            .:|..::|:.:||||::.|:|:....|.|.|.|.... |..:.|.........:|..||:.|.:.
Zfish  1136 SRRINMIQTEEQYIFIHDAILEACLCGETAIPITEFGLSYKDMLSVDSQTNTSQLREEFQTLNSV 1200

  Fly  1198 ADEIS-KSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIA 1261
            ...:. :.|||.....|..||||.:::|.||....|.. ...:.:.||||:.::.:.....|::.
Zfish  1201 TPHLDVEECSVSLLPRNREKNRSMDVLPPDRALAFLVS-NEGDGNNYINAALMDSFLQPAAFVVT 1264

  Fly  1262 QDPLENTIGDFWRMISEQSVTTLVMISEI--GDGPRKCPRYWADDEV-QYDHILVKYVHSESCPY 1323
            ..||..|..||||::.:...|::||::::  .:....|.:||.:..: ||..:.|:.:...:...
Zfish  1265 PHPLPTTTTDFWRLVFDYGCTSIVMLNQLNQSNSAWPCLQYWPETGMQQYGPMTVELLSRSTDEN 1329

  Fly  1324 YTRREFYVTNCKIDDT--------------------LKVTQFQYNGWPTVDGEVPEVCRGIIELV 1368
            ...|.|.|.|...|..                    |.|..||:..| :...|:|:..:..:.|:
Zfish  1330 VVTRLFRVNNITRDPRENLPCWNADSRIPKKLQEGHLVVRHFQFLRW-SAYREIPDSKKAFLNLL 1393

  Fly  1369 DQAYNHYKNNKNSGCRSPLT-VHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTG 1432
            .|.....:.     |....| |||..|..||..|.|..::::.:.....||:....:.||:.:..
Zfish  1394 AQVQKWQRE-----CGDGRTIVHCLNGGGRSGTFCACTMIMEMVHHHNMVDVFYAVKTLRNSKPN 1453

  Fly  1433 LINSYAQYEFLHRAIINYSD 1452
            ::.|..||.|.:...:.|.|
Zfish  1454 MVESMEQYRFCYELALEYLD 1473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653	20/124 (16%)
		Ig	150..221	CDD:143165	16/96 (17%)
		fn3	237..321	CDD:278470	20/93 (22%)
		FN3	339..432	CDD:238020	19/122 (16%)
		FN3	439..535	CDD:238020	25/97 (26%)
		PTPc	892..1155	CDD:214550	89/268 (33%)
		PTPc	920..1155	CDD:238006	80/240 (33%)
		PHA02694	<1121..1206	CDD:177476	24/86 (28%)
		PTPc	1186..1449	CDD:214550	69/287 (24%)
		PTPc	1216..1449	CDD:238006	61/256 (24%)
ptprua	XP_005159609.1	MAM	26..186	CDD:279023	26/119 (22%)
		MAM	26..184	CDD:99706	25/117 (21%)
		I-set	188..281	CDD:254352	14/94 (15%)
		FN3	285..356	CDD:214495	17/76 (22%)
		FN3	385..485	CDD:238020	17/99 (17%)
		FN3	494..589	CDD:238020	27/104 (26%)
		Y_phosphatase	922..1157	CDD:278528	80/242 (33%)
		PTPc	934..1157	CDD:238006	78/230 (34%)
		PTPc	1189..1470	CDD:214550	69/287 (24%)
		PTPc	1219..1470	CDD:238006	61/257 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810