DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp69D and ptprc

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_021325269.1	Gene:	ptprc / 559154	ZFINID:	ZDB-GENE-050208-585	Length:	1229	Species:	Danio rerio

Alignment Length:	1269	Identity:	336/1269 - (26%)
Similarity:	544/1269 - (42%)	Gaps:	338/1269 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 TASTITIGWNPPPPDLIDYIQYYELIVSESGEVPKVIEEAIYQQNSRNLPYMFDKLKTATDYEFR 410
            |:|.||   ...|||                       .||  .|:.::|:..:..|.::...:.
Zfish    27 TSSNIT---TSKPPD-----------------------SAI--SNNSSIPHADNSTKVSSGESYA 63

  Fly   411 VRACSDLTKTCG---PWSEN--------VNGTTMDGVATKPTNLSIQCHHDNVTRGNSIAINWDV 464
            ....::..:.|.   .|:||        :|..|.|   .|.....|:...:|.|..|.
Zfish    64 GTGTTENQEKCRYNIIWNENEAIINVSSINDKTSD---HKNQKYRIELKQNNETISNG------- 118

  Fly   465 PKTPNGKVVSYLIHLLGNPMSTVDREMWGPKIRRIDEPHHKTLYESVSPNTNYTVTVSAITRHKK 529
             ::|           |..|:                        :.|.|.||||:.|...:..:|
Zfish   119 -RSP-----------LTIPL------------------------KKVEPCTNYTIHVDNCSLQEK 147

  Fly   530 NG-----------------------EPATGS---CLMPVSTPDAIGRTMWSKVNLDSKYVLKLYL 568
            |.                       |..|.:   | :.:.|.|:..::....:..:..|.:|:::
Zfish   148 NSFHFNATESKIHTAKLHGDDQVCVEDGTWNLTKC-VNIETKDSCLQSPIVFIQSECTYTIKIHM 211

  Fly   569 PKISERNGPICCYRLYLVRINNDNKELP-------DPEKLNIATYQEVHSDNVTRSSAYIAEMIS 626
            |.:.    |...|          |:.:|       .|::.|.:.: .||.|          :.||
Zfish   212 PPLK----PEIQY----------NETIPTKFVWENKPKECNESNF-NVHCD----------KEIS 251

  Fly   627 SKYFRPEIFLGDEKRFS-----ENNDIIRD--NDEICRKC----------LEGTPFLRKPEII-H 673
            ......:::|...|:::     |.||.|.:  |.||...|          |..:.|    ||: .
Zfish   252 GFKVNQDVYLIPSKKYNCIGKYEFNDTISESNNTEITISCDWKNETYIQNLTSSSF----EIVWT 312

  Fly   674 IPPQ------------GSLSNSDSELPILSEKDNLIKG--AN--------LTEHALKI------- 709
            :.|:            |..:|      ::..|..|:..  ||        .|:::..:
Zfish   313 LSPEEKCQGIKWEGFSGICNN------VVQRKCQLVNDTTANCAFTDLKPFTDYSCSLTAKVKEL 371

  Fly   710 -----LESKLRDKRNAVTSDENPILSAVNPNVPLHDSSRDVFDGEIDINSNYTGFLEIIVRDRN- 768
                 .:|.:.:|    |...:||.:..|.|.             .|||..|.....|:|:.:.
Zfish   372 GHFDTYKSFIEEK----TKSFHPIFNQTNLNT-------------TDINQFYLTRNSIVVKCKKK 419

  Fly   769 ------NALMAYSKYFDIITPATEAEPIQSL----------NNMDYYLSIGVKAGA--------- 808
                  |..:.|  |..|:....:.|  |::          .|:.|:.:..:|..|
Zfish   420 LETPDWNGQVGY--YIAILLNNGKTE--QNITNRTSCTFLFENLSYHTNYIIKITARNKEGNETT 480

  Fly   809 ----------------------VLLGVILVFIVLWVFHHKKTKNELQGEDTLTLRDSLSRALFGR 851
                                  ::..|.|:|::..:|..|:.:.  ..||.:.|...|.|
Zfish   481 ISASISTSYNEKAVIGFLAFLIIVTSVALLFVLYKIFLLKRKRT--PEEDEICLTQPLRR----- 538

  Fly   852 RNHNHSHFITSGNHKGFDAGPIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKE 916
                              ..||:...|.:||:.:..|....|:.|::.:|..|::.|.|.:...|
Zfish   539 ------------------VEPIYPDGLIDAYRTKIADESRLFMDEFQSIPRIFNNYTIKEAKRPE 585

  Fly   917 NACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIW 981
            |..||||.||..||..||.|:  :| ...|||||:|:.||:|.||:|.||||.:.||.|||:|:|
Zfish   586 NQSKNRYVDILPYDYNRVTLS--SG-SYGDYINASFIEGYQEPKKYIAAQGPKDETIVDFWQMMW 647

  Fly   982 EQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANV 1046
            ||...||||:|..||.||.|||:|||....:|:.|.|.:||...|....|||.|.|.:    ||.
Zfish   648 EQKSSIIVMVTRCEEGNKVKCAQYWPCLDRETEIFDDFVVKIKTEEHCPDYIIRHLVL----ANK 708

  Fly  1047 GEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALD 1111
            .|:...|:||...:::|.|...|..|..::|..|::||..:...|||:||||||||||||.:.:|
Zfish   709 REKASEREITHIQFISWPDHGVPTDPGQLLKLRRRVNSFKNFFSGPIVVHCSAGVGRTGTYIGID 773

  Fly  1112 SLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESL 1176
            ::|:.||.|:.|.||..|..||.||..:||...|||.::.||::...||.|:|.:....|.:.::
Zfish   774 AMIESLEAENRVDIYGFVAKLRRQRCLMVQVEAQYILIHTALIEHNQFGETEILLSEFHSVLNTI 838

  Fly  1177 KRKP-NEGKCKLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVIL-------- 1232
            :.|. ||.  .:|:||:||....:  .::.:.|.:|||..|||..::||||.|||:.
Zfish   839 REKQGNES--IMEIEFQKLPKFKN--WRTINTGSSEENKDKNRDSKVIPYDYNRVLFRLDIAGNQ 899

  Fly  1233 TPLP----------MRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMI 1287
            |..|          ..|::.||||||::||...::.|.||.||.||..:|..|:.:|...|:||:
Zfish   900 TSDPEDDTYSSDEEEEESNEYINASFLDGYWCQKSLIAAQGPLPNTTAEFLLMLYQQQTKTVVML 964

  Fly  1288 SEI-GDGPRKCPRYWADDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWP 1351
            ::. .||...|.:||.|::..:..:.::...:||.|.|.:|...:.:.|.::.|::.|:|:..|.
Zfish   965 TDCQEDGKDLCSQYWGDEKKVFGDMEIEVKKTESFPTYVKRHLEIQSTKKNEILELDQYQFLKWK 1029

  Fly  1352 TVDGEVPEVCRGIIELVDQAYNH--YKNNKNSGCRS-PLTVHCSLGTDRSSIFVAMCILVQHLRL 1413
            :  .|:||..:.:||::.....:  |.|:|.:  || |:.||||.|:.|:.:|.|:..|:.....
Zfish  1030 S--SELPENAQELIEMIKNIRENGKYDNSKKN--RSIPIVVHCSNGSSRTGLFCALWNLMDCSLT 1090

  Fly  1414 EKCVDICATTRKLRSQRTGLINSYAQYEFLHRAI 1447
            ||.||:....:.||.:|.|::.::.||:||:.|:
Zfish  1091 EKLVDVFQVVKNLRKERQGMVETFEQYQFLYTAL 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653
		Ig	150..221	CDD:143165
		fn3	237..321	CDD:278470
		FN3	339..432	CDD:238020	17/96 (18%)
		FN3	439..535	CDD:238020	18/118 (15%)
		PTPc	892..1155	CDD:214550	120/262 (46%)
		PTPc	920..1155	CDD:238006	112/234 (48%)
		PHA02694	<1121..1206	CDD:177476	28/85 (33%)
		PTPc	1186..1449	CDD:214550	92/284 (32%)
		PTPc	1216..1449	CDD:238006	83/254 (33%)
ptprc	XP_021325269.1	FN3	395..476	CDD:214495	18/97 (19%)
		PTPc	561..817	CDD:214550	120/262 (46%)
		PTPc	874..1125	CDD:238006	83/255 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.770