Protein Alignment Ptp69D and ptprk

DIOPT Version :9

• Sequence 1: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Sequence 2: XP_021324239.1
• Gene: ptprk / 555348
• ZFINID: ZDB-GENE-030131-9834
• Length: 1500
• Species: Danio rerio
• Alignment Length: 1620
• Identity: 377/1620 - (23%)
• Similarity: 608/1620 - (37%)
• Gaps: 452/1620 - (27%)

  Fly    69 KIRTEPLKSND-------------DGSENNDSQDFIKYKNVLALLDVNIKDSGN--YTCTAQTGQ 118
            :::...:|.||             |||...         .:..|:.||.....|  :..||.||:
Zfish    91 RLQLPVMKENDTHCIDFNYLLYCPDGSSPG---------TLNVLVKVNKGPLANPIWNITACTGK 146

  Fly   119 N-HSTEFQVRPYLPS-----------------------KVLQSTPDR---------IKRKIKQDV 150
            : ...|..|..:.|:                       :||....|:         ::....|:.
Zfish   147 DWMKAELAVSTFWPNEYQVIFEAEVTNGRRGFIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNA 211

  Fly   151 MLYCLIEMYPQNETTNRNLKWL--KDGSQFEFLDTFSSISKLNDTHLNFTLEF--TEVYKKENGT 211
            ...|:..:   .:..|..| ||  ::|......:      |.|..|..|...|  .||..::...
Zfish   212 TFQCIATV---RDAVNNKL-WLQRRNGEDIPVAE------KKNINHRKFAASFRLKEVSSQDQDL 266

  Fly   212 YKCTVFDDTGLEITSKEITLFVMEVPQVSIDFAKAVGANKIYLNWTVND----GNDPIQKFFITL 272
            |:|....:.|..: |....|.|.|.|: .|...:.:|....||...:|.    |:.|     |.|
Zfish   267 YRCVTQSERGSGV-SNFAGLIVREPPR-PIAPPQLLGVGPTYLLIQLNANSIFGDGP-----IIL 324

  Fly   273 QE------AGTPTFTYHKDFINGSHTSYILDHFKPNTTYFLRIV----GKNSIGNGQPTQYPQGI 327
            :|      :|:.|.|:..:..|     |.|.|..|:|.|.:|::    |:.  |.|||.  |..|
Zfish   325 KEVEYRMTSGSWTETHAVNSPN-----YKLWHLDPDTEYEIRVLLTRPGEG--GTGQPG--PALI 380

  Fly   328 T-TLSYDPIFIPK-VETTGSTASTITIGWNPPPPDLIDYIQYYELIVSESGEVPKVIEEAIYQQN 390
            | |...:|:..|| ::...:.|..|.:.|
Zfish   381 TRTKCAEPMRTPKSLKIAETQARFIAVDW------------------------------------ 409

  Fly   391 SRNLPYMFDKLKTATDYEFRVRACSDLTKTCGPWSENVNGTTMDGVATK--------PTNLS--- 444
             .:|.|...:..|     |.|..|....||  |.....:...||..|.:        .||:|
Zfish   410 -ESLGYNITRCHT-----FNVTICYHYHKT--PNHSKADCLEMDPKAPRHVVGNLPPNTNVSLKM 466

  Fly   445 ---------------IQCHHD-----------NVTRGNSIAINWDVPKTPNGKVVSYLIHLLGNP 483
                           ||...|           :....:.|::.|..|..|||.:..|.|..  :.
Zfish   467 ILTNPEGRKESDETLIQTQEDVPGPVPKEFVRSTPSEDKISLQWKEPLEPNGIITQYEISY--SS 529

  Fly   484 MSTVDREMWGPKIR---RIDEPHHKTLYE--SVSPNTNYTVTVSAITRHKKNGEPATGSCLMPVS 543
            :.:.|..:  |.:|   .:..|.:.:.|.  .:.|.|.|...:.|.| .|..|.|.|.:....:|
Zfish   530 VHSFDPSV--PLLRPPLLVSLPWNTSRYNFTLLHPGTTYQFLIRAST-SKGFGPPTTLNVTTNIS 591

  Fly   544 TPDAIGRTMWSKVNL-DSKYVLKLYLPKISERNGPICCYRLYLVRIN--NDNKELPDPEKLNIAT 605
            .| .:.....|:.:| ::...:.:.|.....:..||..|::.:..||  ...:|         |.
Zfish   592 AP-TLEEYDGSEASLNETATTITVLLKPAQAKGAPISAYQIVVKEINPHRGRRE---------AG 646

  Fly   606 YQEVHSDNVTRSSAYIAEMISS---KYFRPEI-----------FLGDEKRF--------SENND- 647
            ..|.:.:.|:..||     :||   .||..||           .:||.|.:        :...|
Zfish   647 GGECYREPVSYQSA-----VSSGLPYYFAAEIPPRNLQEPLPFTVGDNKTYHGYWNAPLAPRKDY 706

  Fly   648 ------IIRDNDEICRKCL----EGTPFLRKPEIIHIPPQGSLSNSDSELPILSEKDNLIKGANL 702
                  :.|...|...:||    :|.  ..:||:|..|.:              :.|.::|.|.:
Zfish   707 NIYFQAVSRVEKESKTQCLKLAFKGA--TEEPEVIPDPAK--------------QTDQVVKIAGI 755

  Fly   703 TEHALKILESKLRDKRNAVTSDENPILSAVNPNVPLHDSSRDVFDGEIDINSNYTGFLEIIVRDR 767
            :...|..:...|                                             :.|::..:
Zfish   756 SAAVLVFILLVL---------------------------------------------VAILLLKK 775

  Fly   768 NNALMAYSKYFDIITPATEA------EPIQSLNNMDYYLSIGVKAGAVLLGVILVFIVLWVFHHK 826
            ..:..:||.|..:.....:|      |....:|:||                          ...
Zfish   776 RRSYYSYSYYLKLAKKRKDAIGNTRQEMTHMVNSMD--------------------------RSY 814

  Fly   827 KTKNELQGED--TLTLRDSLSRALFGRRNHNHSHF--------------ITSGNHKG-------- 867
            ..::.|..|:  |:|..||          ||.|:.              ||..||..
Zfish   815 ADQSTLHAEEPMTVTFMDS----------HNFSNRLPNEPLVPTAVLVPITDENHTAAAAAAENS 869

  Fly   868 --FDAGPIHRLDLENAYK-----------------NRHKDTD-YGFLREYEMLPNRFSDRTTKNS 912
              .|....|....|:.|:                 |..|.:| |||..|||    .|.:..:.:.
Zfish   870 RLLDIPRYHCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYE----SFFEGQSASW 930

  Fly   913 DL---KENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFV--------------------- 953
            |.   ::|..||||.:|.|||.:||.|..:....::||||||::
Zfish   931 DAAKKEQNRTKNRYGNIIAYDHSRVILQPMEDDPSSDYINANYIDVSGDAASSSIGERVRNVSPS 995

  Fly   954 ------IGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFD 1012
                  .||:....:|..|||:..|:.|||||||::....|||:|||.|..:.||.||||:   |
Zfish   996 LIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD---D 1057

  Fly  1013 TKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIK 1077
            .:.:||..|.|.:.....:|:.||..:.:...|     :.|::.|:|:..|.|...|.|..|::.
Zfish  1058 AEVYGDFKVTFVEVEPLAEYVVRTFTLERRGFN-----EVREVKQFHFTGWPDHGVPYHATGLLS 1117

  Fly  1078 FIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQS 1142
            |||::........|||:||||||.||||..:.:|.::...|.|..|.|||.|..||.:|..:||:
Zfish  1118 FIRRVKMSNPPTAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQT 1182

  Fly  1143 LKQYIFLYRALLDTGTFGNTDICI-DTMASAIESLKRKPNEGKCKLEVEFEKL-LATADEISKSC 1205
            .:||||::.|:|:....|.|.|.: :..|:..:.::.........|:.||:.| ..|.....:.|
Zfish  1183 EEQYIFIHDAILEACLCGETAIPVCEFKAAYYDMIRIDSQSNSSHLKDEFQTLNSVTPQPQPEDC 1247

  Fly  1206 SVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFI------EGYDNSETFIIAQDP 1264
            |:.....|:.|||..:.:|.||....|..:. .|:|.||||:.:      :.|.....||:.|.|
Zfish  1248 SIALLPRNHDKNRFMDNLPPDRCLPFLITID-GESSNYINAALMDPSEEYQSYRQPAAFIVTQHP 1311

  Fly  1265 LENTIGDFWRMISEQSVTTLVMISEIGDGPRKCPRYWADD-EVQYDHILVKYVH-SESCPYYTRR 1327
            |.||:.||||::.:...|::||::|| |..:.||:||.:: .::|..:.|..:. |..|...:|.
Zfish  1312 LPNTVKDFWRLVYDYGCTSIVMLNEI-DLAQGCPQYWPEEGMLRYGPVQVDCISCSMDCDVISRL 1375

  Fly  1328 EFYVTNC--KIDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNSGCRSPLTVH 1390
             |.:.|.  ..:..|.|.||||.|| ....|||...|..::|:.|.....:..:....|:  .:|
Zfish  1376 -FRICNLTRPQEGYLMVRQFQYLGW-AGHREVPASKRSFLKLILQVDKWQEECEEGDGRT--IIH 1436

  Fly  1391 CSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY 1450
            |..|..||.:|.|:.|:.:.::.:..||:....:.||:.:..:::|..||.|.:...:.:
Zfish  1437 CLNGGGRSGMFCAISIVCEMIKRQNVVDVFHAVKSLRNSKPNMVDSPEQYRFCYDLALEF 1496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653	20/106 (19%)
		Ig	150..221	CDD:143165	15/74 (20%)
		fn3	237..321	CDD:278470	26/97 (27%)
		FN3	339..432	CDD:238020	13/93 (14%)
		FN3	439..535	CDD:238020	27/137 (20%)
		PTPc	892..1155	CDD:214550	103/292 (35%)
		PTPc	920..1155	CDD:238006	95/261 (36%)
		PHA02694	<1121..1206	CDD:177476	25/86 (29%)
		PTPc	1186..1449	CDD:214550	81/273 (30%)
		PTPc	1216..1449	CDD:238006	73/242 (30%)
ptprk	XP_021324239.1	MAM	30..191	CDD:214533	19/108 (18%)
		IG_like	201..282	CDD:214653	18/91 (20%)
		fn3	293..370	CDD:306538	22/86 (26%)
		fn3	491..582	CDD:306538	20/95 (21%)
		PTPc	940..1195	CDD:238006	95/262 (36%)
		PTPc	1257..1495	CDD:238006	73/243 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910