DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp69D and CG42327

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster

Alignment Length:	1506	Identity:	291/1506 - (19%)
Similarity:	473/1506 - (31%)	Gaps:	554/1506 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EAVAWKLGNQTINKNHTRYKIRTEPLKSNDDGSENNDS--QDFIKYKNVLALLDVNIKDSGNYTC 112
            |.||.|..:...:   ::..|..|......|.:|...:  ::.:..|...|..:.|  :|.|
  Fly    58 EPVAIKAESDMFS---SQTNIEDEKSAKTVDQTETQTASPKENLNVKQTTAAFEKN--ESSN--- 114

  Fly   113 TAQTGQNHSTEFQVRPYLPSKVLQSTPDRIKRKIKQDVMLYCLIEMYPQNETTNRNLKWLKDGSQ 177
               |.::|....||.|....|..:::.|.:|.  :........::..|.|.|.       |..::
  Fly   115 ---TTESHLNGAQVDPVKELKDTETSADTVKE--ESSTTTTSQLDQNPTNVTD-------KKSTE 167

  Fly   178 FEFLDTFSSISKLNDTHLNFTLEFTEVYKKENGTYKCTVFDDTGLEITSKEITLFVMEVPQVSID 242
            .:|.|     .:|:...|:.|.|  ::...|....|..|..::.|...::         |::...
  Fly   168 AQFKD-----ERLSKEILSTTTE--QILLTEKALQKYVVITNSPLRGEAQ---------PEIKDK 216

  Fly   243 FAKAVGANKIYLNWTVNDGNDPIQKFFITLQEAGTPTFTYHKDFINGSHTSYILDHFKPNTTYFL 307
            .:|:..:.|..|         |::.  :|::...|.|     :.:..:.|:...||
  Fly   217 TSKSATSEKSTL---------PLKP--VTIEVPSTTT-----EGVFNTTTTRSSDH--------- 256

  Fly   308 RIVGKNSIGNGQPTQY-----------PQGITTLSYDPIFIPKVETTGSTASTITIGWNPPPPDL 361
                      |:..||           |..:|.:...|  :|...|..||.||.|    |.|...
  Fly   257 ----------GRSMQYSSTTEESSRSSPASVTPMKLIP--LPMTSTPSSTTSTST----PLPTTA 305

  Fly   362 IDYIQYYELIVSESGEVPKVIEEAIYQQNSRNLPYMFDKLKTATDYEFRVRACSD---------L 417
            :.:         .|.|  .||||:..:...|.||            |.|.:..|:         |
  Fly   306 VSF---------ASNE--NVIEESTSKSEVRQLP------------EKRAKFISENSTNAQQLTL 347

  Fly   418 TKTCGPWS--------------------------------------------------------- 425
            ..|...||
  Fly   348 PNTAEVWSLAGMKAVPKAPLTTTTSVPLLNHTDLANDIDMPLNKTELHKEKNLLDWMNIAMLPLT 412

  Fly   426 -----ENVNGTTMDGV--ATKPT------------NLSIQCHHDNVTRGNSIAINWDVPKTPNGK 471
                 |.|..||:|..  ||:.|            ::::....||||...:      :|.||:..
  Fly   413 PENRTEFVVRTTLDATEGATQATTEALVEETHSKSDITVGLEQDNVTTART------MPSTPDPG 471

  Fly   472 VVSYLIHLLGNPMSTVDREMWGPKIRRIDEPHHKTLYESVS------------------------ 512
              |..:::....:.|...|:  |.::::.:..:..|.|:|:
  Fly   472 --SMDLNMTTTTVRTQQLEV--PLVKKMSDAANAKLIEAVTEPQRETEAATEAATFVTLPEKLAT 532

  Fly   513 -----------------------------PNTNYTVTVSAIT------------RH---KKNGEP 533
                                         ...|.|.|:||:|            .|   :::.|.
  Fly   533 FGITARVDSTQTELLNVTTAAAATESGEMSKANSTDTLSAMTSTTTTTARPMSVEHVTPEQDMEA 597

  Fly   534 ATG--------------------SCLMPVSTPDAIGRTMWSKVNLDSKYVLKLYLPKISERNGPI 578
            ||.                    :...||.:..|....  :....::.....|.:...:.....|
  Fly   598 ATSLATTAATSSGTTEAAATSSTTAATPVVSEAATAAE--ASATSEATTAATLSVATTAASTTEI 660

  Fly   579 CCYRLYLVRINNDNKELPD---------PEKLNIATYQEVHSDNVTRSSAYIAEMISSKYFRPEI 634
            ......:..|.:||.:..:         ||....||...| ....|..|..:|..:|:. .||||
  Fly   661 AMKATQISNIRDDNDDNSNDVIVATTKFPESEQAATTASV-EPTTTSVSVRVAGEVSTS-IRPEI 723

  Fly   635 FLGDEKRFSENNDIIRDNDEICRKCLEGTPFLRKPEIIHIPPQGSLS----------NSDSELPI 689
            .:     .|..|..|.|........  .||  .:.||..|..:.:|.          :..:||..
  Fly   724 IV-----TSTRNSTIVDTSTSATSV--ATP--TQTEIAQISNEVNLEAVTVKTRDGLSDTNELRT 779

  Fly   690 LSEKDNLIKGANLTEHALKILESKLRDKRNAVTSD---ENPILSAVNPNVPLHDSSRDVFD-GEI 750
            ..:.||.:      .:::.|.||.|.....||.::   .|.:||.|:.....|:||.:..: ||.
  Fly   780 AEKTDNAV------NNSVAITESDLGALATAVETNPTTTNSLLSDVSKLSKEHESSLETNNIGEA 838

  Fly   751 DINSN--------------------YTGFLEII----------VRDRNNALMAYSK--------- 776
            ...|.                    .||..||:          |.|..:.....:|
  Fly   839 PPESTTPAAPATVAVATDESTAAPAATGGQEIVREGQHHDGQQVADEQDTEQQLAKTTMAVTTTT 903

  Fly   777 -----------------------------------------------YFDIIT------------ 782
                                                           ||:..|
  Fly   904 TSATTTTTSTTTTTTETPLTTTTMQPVEISLLDDSTTTTTTTPAPPVYFESSTVASTTIRSSTTM 968

  Fly   783 -PATEAEPIQS------------LNNMDYY----------LSIGVKAGAVLLGVI-LVFIVLWVF 823
             |.|.....||            .|.:|:.          :::.:.....::||: |:.:|.:::
  Fly   969 LPETTTASTQSPSEMPPTFMAPYPNELDHMQTNAQDNGTDVNVIIAITVSVIGVVALILLVAFLY 1033

  Fly   824 -HHKKTKNELQGE------------DTLTLRDSLSRALFGRRNHNHSHFITSGNHKGFDAGPIHR 875
             ..|:.|....|:            |.:::..|:.|.  ||.......  |.|| ..|| .|..|
  Fly  1034 LMRKRQKQTSYGQRCRPVSLDAYSLDNVSVLGSVRRK--GRDMRASKR--TYGN-AAFD-DPSLR 1092

  Fly   876 LDLENA-----YKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENAC--KNRYPDIKAYDQTR 933
            .:|..|     :..|..|.    ..|:..:|     :....:|.....|  ||||.::....:||
  Fly  1093 HNLLTASELARFVERRSDV----FEEFRDVP-----QIIARADEVPPGCEDKNRYANVIPLPETR 1148

  Fly   934 VKLAVINGLQTTDYINANFVIGYKERKK-FICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEY 997
            |.|........|:|||||:|.|.::... :|..|.|:|||..|||||||||...:|:..|:|.|.
  Fly  1149 VVLQRQGDDDKTEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATDLSEN 1213

  Fly   998 NKAKCAKYWPEK--VFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHY 1060
            ...:||:|.|..  :.:...:||..|..........|...||.:.:     .:.|:.|::|.|.|
  Fly  1214 GIERCAEYLPPSATLDNHSSYGDYQVTLKHREVKDRYAISTLVLKR-----VDGEESRELTHYWY 1273

  Fly  1061 LTWKDFMAPEHPHGIIKFIRQINS---VYSL---------------------------------- 1088
             .|.:...|.....||..:.:..|   .|||
  Fly  1274 -KWPEAGVPAEEAPIIAMLLEARSSLKSYSLEQANELREKSATLETSMDADGSKAEAGSTSSHEI 1337

  Fly  1089 ------------QRGPILVHCSAGVGRTGTLVALDSLIQQLE-EEDSVSIYNTVCDLRHQRNFLV 1140
                        |:||:.||||.|.|||||::|.|..|:.|| .:.||.|...|..:|..|...|
  Fly  1338 NGNISSRSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVYYVRRGRASAV 1402

  Fly  1141 QSLKQYIFLYR 1151
            |:.:||.|:|:
  Fly  1403 QTKEQYEFIYK 1413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653	16/93 (17%)
		Ig	150..221	CDD:143165	13/70 (19%)
		fn3	237..321	CDD:278470	12/83 (14%)
		FN3	339..432	CDD:238020	26/163 (16%)
		FN3	439..535	CDD:238020	23/175 (13%)
		PTPc	892..1155	CDD:214550	92/315 (29%)
		PTPc	920..1155	CDD:238006	88/285 (31%)
		PHA02694	<1121..1206	CDD:177476	12/31 (39%)
		PTPc	1186..1449	CDD:214550
		PTPc	1216..1449	CDD:238006
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	88/286 (31%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	88/286 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100