DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp69D and PTPRQ

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_016874762.1	Gene:	PTPRQ / 374462	HGNCID:	9679	Length:	2536	Species:	Homo sapiens

Alignment Length:	1454	Identity:	318/1454 - (21%)
Similarity:	499/1454 - (34%)	Gaps:	461/1454 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ENEAVAWKLGNQTINKNHTRYKIRTEPLKSNDDGSENNDSQDFIKYKNVLALLDVNIKDS--GN- 109
            :|..|:..:...||...:|.:      |.::......|.|.|.|:     ...|.:|.:.  ||
Human  1229 DNMTVSTIIDKLTIFSYYTFW------LTASTSVGNGNKSSDIIE-----VYTDQDIPEGFVGNL 1282

  Fly   110 -YTCTAQTGQNHSTEFQVRP-----YLPSKVLQSTPDRIKRKIKQDVMLYCLIEMYPQNETTNRN 168
             |...:.|..|.|.....:|     |..|.:||.||..::                |...|..|:
Human  1283 TYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVR----------------PPLVTYERS 1331

  Fly   169 LKWLKDGSQFEFLDTFSSISKLNDTHLNFTLEFTEVYKKENGTYKCTVFDDT---GLEITSKEIT 230
            :             .|.::.|..|    :.|:.|.  ..|.|      |.||   .|.|.::|
Human  1332 I-------------YFDNLEKYTD----YILKITP--STEKG------FSDTYTAQLYIKTEE-- 1369

  Fly   231 LFVMEVPQVS--IDFAKAVGANKIYLNWTVNDGNDP-------IQKFFITLQEAGTPTFTYHKDF 286
                :||:.|  |:..|.:.:..:.|:|      ||       |..:.:|||   .|...|  .|
Human  1370 ----DVPETSPIINTFKNLSSTSVLLSW------DPPVKPNGAIISYDLTLQ---GPNENY--SF 1419

  Fly   287 INGSHTSYILDHFKPNTTYFLRIVGKNSIGNGQ------------PTQYPQGITTLSYDPIFIPK 339
            |. |....||:...|.|.|......:...|.|.            |...||.:|.::
Human  1420 IT-SDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLIN-------- 1475

  Fly   340 VETTGSTASTITIGWNPPP-PDLIDYIQYYELIVSESGEVPKVIEEAIYQQNSRNLPY------- 396
                 .|:..:.:.|:|.| |                |.:.||....|::..:..:.|
Human  1476 -----CTSDFVWLKWSPSPLP----------------GGIVKVYSFKIHEHETDTIYYKNISGFK 1519

  Fly   397 ---MFDKLKTATDYEFRVRACSDLTK--TCGPWSENVNGTTMDGVATKPTNLSIQCHHDNVTRGN 456
               ....|:..:.|..||.|   .||  ....:|..|..||.:.|.....|:  ||   ..|...
Human  1520 TEAKLVGLEPVSTYSIRVSA---FTKVGNGNQFSNVVKFTTQESVPDVVQNM--QC---MATSWQ 1576

  Fly   457 SIAINWDVPKTPNGKVVSYLIHLLGNPMSTVDREMWGPKIRRIDEPHHKTLYESVSPNTNYTVTV 521
            |:.:.||.||..||.:..|::        ||:|..     .::....|...:..:..||:|...|
Human  1577 SVLVKWDPPKKANGIITQYMV--------TVERNS-----TKVSPQDHMYTFIKLLANTSYVFKV 1628

  Fly   522 SAITRHKKNGEPATGSCLMPVSTPDAIGRTMWSKVNLDS------------------KYVLKLYL 568
            .|.|...:..|.......:|.:.|.......:|.|...|                  |...:|..
Human  1629 RASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRA 1693

  Fly   569 PKISERNGPICC--------------------------YRLYLVRINN----------DNKELPD 597
            .|..|.....|.                          ||..:....|          ..|.||.
Human  1694 QKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPG 1758

  Fly   598 PEKLNIATYQEVHSDNVTRSSAYIAEMISSKYFRPEIFLG-----------DEKRF-------SE 644
            |..   ...:.||   |..:|.:   .||..:..|.:..|           |...|       :|
Human  1759 PPD---GPPENVH---VVATSPF---SISISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSNE 1814

  Fly   645 NNDIIRDND-----------------------------EICRKCLEGTP--------FLRKP--- 669
            .|..|...|                             |:....||..|        |.:.|
Human  1815 ENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEV 1879

  Fly   670 ---EIIHIPP----------QGSLSNSDSELPI------LSEKDNL--------IKGA---NLTE 704
               ::..:||          |..:...|....:      :.:|.|.        :||.   |::.
Human  1880 TKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISV 1944

  Fly   705 HAL-------KI-------LESKLRDK-----------RNAVTS--------------DENPILS 730
            :|:       |:       :::..|.|           :..|||              |..||.:
Human  1945 YAVNSAGAGPKVPMRITMDIKAPARPKTKPTPIYDATGKLLVTSTTITIRMPICYYSDDHGPIKN 2009

  Fly   731 A---VNPNVPLHD------------SSRDVFDGE-------IDINSNYTGFLEIIVRDRNNALMA 773
            .   |......||            .:|..|..|       .:..:.::|..||.:...:||.|.
Human  2010 VQVLVTETGAQHDGNVTKWYDAYFNKARPYFTNEGFPNPPCTEGKTKFSGNEEIYIIGADNACMI 2074

  Fly   774 YSKYFDI-----------------------ITPATEAEPIQSL------NNMDYYLSIGVKAGAV 809
            ......|                       .|.:..::|:::|      ..::..||:.:    .
Human  2075 PGNEDKICNGPLKPKKQYLFKFRATNIMGQFTDSDYSDPVKTLGEGLSERTVEIILSVTL----C 2135

  Fly   810 LLGVILVFIVLWVFHHKKTKNELQGE---------DT------------LTLRDS-LSR--ALFG 850
            :|.:||:...::.|...:.|.:..|.         ||            |.|:|. |:|  :.|.
Human  2136 ILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRYSSFFF 2200

  Fly   851 RRNH-------NHSHFITSGNHKGFDAGPIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRT 908
            ||..       ::...|...:.|.| ...:..|...|..|         |..|:..||....|.:
Human  2201 RRKEIFVIQLLSYRKSIKPISKKSF-LQHVEELCTNNNLK---------FQEEFSELPKFLQDLS 2255

  Fly   909 TKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTI 973
            :.::||..|..|||:|:||.|:..||||.....:..:|||||:::.||....:||..|||:..|:
Human  2256 STDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTV 2320

  Fly   974 DDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLN 1038
            .|||||:||...:.:||||...|..:.:|.:||||.......||||::....|....|:..|.|.
Human  2321 GDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLK 2385

  Fly  1039 VSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGR 1103
            :.::       .|...:.|.::..|.:...||:...:|.|::.:.:..:....|::|||||||||
Human  2386 IERH-------GDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGR 2443

  Fly  1104 TGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD--TGTFGNTDICI 1166
            ||..:|||.|.|.:.:.|.|.||..|.:||.:|..:||:|.|||||::.:||  :....|..||.
Human  2444 TGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICF 2508

  Fly  1167 DTMASAIESLKRKPNEGKCKLEVE 1190
            ...::..:.......||..:||.|
Human  2509 VNYSALQKMDSLDAMEGDVELEWE 2532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653	17/96 (18%)
		Ig	150..221	CDD:143165	13/73 (18%)
		fn3	237..321	CDD:278470	24/104 (23%)
		FN3	339..432	CDD:238020	19/105 (18%)
		FN3	439..535	CDD:238020	23/95 (24%)
		PTPc	892..1155	CDD:214550	97/262 (37%)
		PTPc	920..1155	CDD:238006	89/234 (38%)
		PHA02694	<1121..1206	CDD:177476	26/72 (36%)
		PTPc	1186..1449	CDD:214550	3/5 (60%)
		PTPc	1216..1449	CDD:238006
PTPRQ	XP_016874762.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910