DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp69D and Y71G12B.31

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	NP_001293450.1	Gene:	Y71G12B.31 / 3565511	WormBaseID:	WBGene00044348	Length:	423	Species:	Caenorhabditis elegans

Alignment Length:	417	Identity:	115/417 - (27%)
Similarity:	186/417 - (44%)	Gaps:	83/417 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   802 IGVKAGAVLLGVILVFIVLWVFHHKKTKNELQGED----------------------TLTLRD-- 842
            |...|.::||...:...:|:|:|  ||.:.|:...                      .:|.::
Worm     8 IACLAASMLLMCCVTCFILYVYH--KTSSRLRRASRGRTPKQVQQLPKVEEPAPPPVEVTTKEIA 70

  Fly   843 --SLSRALFGRRNHNHSHFITSGNHKGFDAGPIHRLDLENAYKNRHKDTDY---GFLR------- 895
              :.:.|..|:...|....|::...|..|...|....:..|......:|||   .||.
Worm    71 VIAAAAAADGKNQINGFQKISTPAAKRPDKLRIDTNKVCPAQSAIAMETDYSADSFLASMTKEST 135

  Fly   896 --------EYEMLPNRFSDRTTKNSD-LKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINAN 951
                    |:.:|....:.|.|:::| ...:|..|||.||..||.|.|:      |.|.|||||:
Worm   136 NRRRLLQDEFLVLSRTEARRLTRSTDRATRHAAANRYSDIVPYDHTLVE------LDTGDYINAS 194

  Fly   952 FVIGYKERKKFICAQGPMES-------TIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEK 1009
            ||.|..:..::|..|||::|       |:.||||||.:..:..||||...:|....||.:|||..
Worm   195 FVQGESDATRWIATQGPIDSGECIGKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSA 259

  Fly  1010 VFDTKQFGDILVKFAQERKTGDYIERTLNV-----------SKNKANVGEEEDRRQITQYHYLTW 1063
            :..|:::|::.||...|.:...::.|..:|           |..|:....::...:::|:.|..|
Worm   260 MGKTERYGEVDVKLVCELEEKTWVHREFDVSPTSSYSSSTKSSRKSRASRQQSHMKVSQWQYKEW 324

  Fly  1064 KDFMAPEHPHGIIKFIRQINSVYSLQRG-----PILVHCSAGVGRTGTLVALDSLIQQLEEEDSV 1123
            ||..........::|:.|:       ||     ||:||||||:||||..:..|::|.:.|.|..:
Worm   325 KDTGGAPRIANFLEFLLQV-------RGRQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGII 382

  Fly  1124 SIYNTVCDLRHQRNFLVQSLKQYIFLY 1150
            .|::.|...|.||..:|.::|||..:|
Worm   383 DIFSEVNRSRQQRPSMVYTVKQYECIY 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653
		Ig	150..221	CDD:143165
		fn3	237..321	CDD:278470
		FN3	339..432	CDD:238020
		FN3	439..535	CDD:238020
		PTPc	892..1155	CDD:214550	93/298 (31%)
		PTPc	920..1155	CDD:238006	85/254 (33%)
		PHA02694	<1121..1206	CDD:177476	10/30 (33%)
		PTPc	1186..1449	CDD:214550
		PTPc	1216..1449	CDD:238006
Y71G12B.31	NP_001293450.1	PTPc	170..414	CDD:238006	85/253 (34%)
Y71G12B.31	NP_001293450.1	Y_phosphatase	170..412	CDD:278528	85/253 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810