Protein Alignment Ptp69D and ptprub

DIOPT Version :9

• Sequence 1: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Sequence 2: XP_009290693.1
• Gene: ptprub / 335096
• ZFINID: ZDB-GENE-030131-7036
• Length: 1450
• Species: Danio rerio
• Alignment Length: 1538
• Identity: 357/1538 - (23%)
• Similarity: 604/1538 - (39%)
• Gaps: 324/1538 - (21%)

  Fly    59 QTINKNHTRYKIRTEPLKSNDDGSENNDSQDFIKYKNVLALLDVNIKDSGN------YTCTAQTG 117
            ||:::|.|.....:..|.|.|..|.              ..|.|.::.:|.      :..:...|
Zfish    88 QTLSENDTHCVQFSYFLYSRDGHSP--------------GALRVYVRVNGGPLGIPVWNVSGSRG 138

  Fly   118 -QNHSTEFQVRPYLPSK---VLQSTPDRIKRKIKQDVMLYCLIEMYP------------------ 160
             |.|..|..|..:.|::   :|::|.||.......|::|.    .||
Zfish   139 RQWHQVELAVSTFWPNEYQILLEATVDRKGYIAVDDILLL----NYPCYKAPHFSRLGDVEVNAG 199

  Fly   161 QNET--------TNRNLKWLKDGSQFEFLDTFSSISKLNDTHLNFTLEFTEVYKKENGTYKCTVF 217
            ||.|        .:...|:|.:....| :.:..|:..|.......:.:..:|.|.|...|:|...
Zfish   200 QNATFQCVAAGRPSEAEKFLLERHNGE-VSSGGSVKHLGRNRFAVSFQLEDVQKPEQDLYRCVTQ 263

  Fly   218 DDTGLEITSKEITLFVMEVPQVSIDFAKAVGANKIYLNWTVND----GNDPIQKFFITLQEAGTP 278
            ...|..:::  ....:::||...|...:.:.|...||...:|.    |:.||.:..|..:.:..|
Zfish   264 SSRGSGVSN--FAELIVKVPPSPIAPPQLLRAGSTYLIIQLNTNSILGDGPIIRREIEYRASLAP 326

  Fly   279 TFTYHKDFINGSHTSYILDHFKPNTTYFLRIV----GKNSIGNGQPTQYPQGITTLSYDPIFIPK 339
                ..:.:..:..:|.|.|..|:|.|.:.::    |:...|       |.|...:|......|.
Zfish   327 ----WSEILGVNMVTYKLWHLDPDTEYHISVLLTRPGEGGTG-------PPGPPLISRTKCAEPM 380

  Fly   340 VETTGSTASTI-----TIGWNPPPPDL-------IDYIQYYELIVSESGEVPKVIEEAIYQQNS- 391
            ....|..||.|     |:.|..|..:|       :.....|.......|....|.|....:.|:
Zfish   381 RALRGLRASEIQSRQLTLQWEVPAFNLTRCHTYSVSLCYRYTTAGGGGGHNTTVRECLAVEHNTS 445

  Fly   392 ----RNLPYMFDKLKTATDYEFRVRACSDLTKTCG---------PWSENVNGTTMDGVATKPTNL 443
                |:||..         :..::|..  |..|.|         ...|::.|    |:|  |.:|
Zfish   446 RFTLRDLPPF---------HTIQIRLA--LANTEGKKEGKEVMFQTEEDIPG----GIA--PESL 493

  Fly   444 SIQCHHDNVTRGNSIAINWDVPKTPNGKVVSYLIHLLGNPMSTVDREMWGPKIRRIDEPHHKT-- 506
            :.....|      .|.:.|:.|..|||.:..|.|.......|.....:.||: |.:.:..::|
Zfish   494 TFTPLED------MIFLKWEEPVEPNGLITQYEISYQSIESSDPGINVPGPR-RTVSKLKNETYH 551

  Fly   507 LYESVSPNTNYTVTVSAITRHKKNGEPATGSCLMPVSTPDAIGRTMWSKVNLDSKYVLKLYLPKI 571
            ::.::.|.|.|.::|.|.|. |..|:.|.......:|.|......|.|.:: :::..:.:.|...
Zfish   552 MFSNLHPGTTYLISVRARTA-KGFGQTALTEITTNISAPTFDYGDMPSPLS-ETESTITVLLRPA 614

  Fly   572 SERNGPICCYRLYLVRINNDNKELPDPEKLNIATYQEVHSDNVTRSSAYIAEMISSKYFRPEIFL 636
            ..|..|                         ::|||.|           :.|....|..|.   |
Zfish   615 QGRGAP-------------------------VSTYQVV-----------VEEEAGRKVKRE---L 640

  Fly   637 GDEKRFSENNDIIRDNDEICRKCLEGTPFLRKPEIIHIPPQGSLSNSDSELPILSEKDNLIKGAN 701
            |.:..|    .|...:.|...:   |.|.....|   :||..           |||......|.|
Zfish   641 GIQDCF----PIPTSHGEAQAR---GAPHYYTAE---LPPSS-----------LSEATPFTVGDN 684

  Fly   702 LTEHALKILESKLRDKRNAVTSDENPILSAVNPNVPLHDSSRDVFDGEIDINSNYTGFLEI---- 762
            .|.:.  ...|.|..::|.:                ::..:...|.||..||.     :.|
Zfish   685 HTYNG--YWNSPLDPRKNYL----------------VYFQAMSNFRGETRINC-----IRIARKA 726

  Fly   763 IVRDRNNALMAYSKYFDIITPATEAEPIQSLNNMDYYLSIGVKAGA-----VLLGVILVFI---- 818
            ..:|...||.        :|..:|          :..|.:||.||.     :|||.|::.|
Zfish   727 ACKDHQRALE--------VTQRSE----------EMGLILGVCAGGLVVLILLLGAIIIIIKKGR 773

  Fly   819 --VLWVFH-------------HKKTKNELQGE------DTLTLRDSLSRALFGRRNH-------- 854
              ..:.::             :::.|:.:.|.      |..||::....||.....|
Zfish   774 DYYSYSYYPRKPGNMNKTPITYRQEKSNMMGSMERSFTDQSTLQEDERMALSFMDTHTCSTRSDP 838

  Fly   855 ----NHSHFITSGNHK---GFDAGPIHRLDLENAYK--------NRHKDTD-YGFLREYEMLPNR 903
                |.|..:..|:.:   |....|.|...|..|.:        |:.|..: |||.:|||    .
Zfish   839 RSSMNESSSLLGGSPRRQCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYE----S 899

  Fly   904 FSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFV------IGYKERKKF 962
            |.|....|.  |::..|.|:..:..||:.||||..:.|...:||||||::      .||.....|
Zfish   900 FFDGWDINK--KKDKTKGRHDTLMGYDRHRVKLHPLLGDPNSDYINANYIDIRINREGYHRSNHF 962

  Fly   963 ICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQER 1027
            |..|||.:.|:.|||||:|:::...|||:|.|.|..:.||.||||:   :::.:|||.:...:..
Zfish   963 IATQGPKQETVYDFWRMVWQENCFSIVMITKLVEVGRVKCCKYWPD---ESEMYGDIKITLLKTE 1024

  Fly  1028 KTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGP 1092
            ...:|..||..:.:...:.     :.::.|:|:.:|.:...|.|..|::.|||::.:...|..||
Zfish  1025 TLAEYTVRTFALERRGYSA-----KHEVCQFHFTSWPEHGVPYHATGLLAFIRRVKTSTPLDAGP 1084

  Fly  1093 ILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTG 1157
            ::||||.|.||||..:.||.::...|.|..|.|||.|..|..:|..::|:.:||||::.|:|:..
Zfish  1085 VVVHCSVGAGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRINMIQTEEQYIFIHDAILEAC 1149

  Fly  1158 TFGNTDICIDTMASAIESLKRKPNE-GKCKLEVEFEKLLATADEIS-KSCSVGENEENNMKNRSQ 1220
            ..|.|.|.::..|.|.:.:.|..:: ...:|..||:.|.:....:. :.||:.....|..||||.
Zfish  1150 LCGETAIPVNEFALAYKEMLRVDSQSNSSQLREEFQTLNSVTPHLDVEECSIALLPRNREKNRSM 1214

  Fly  1221 EIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLV 1285
            :::|.||....|.... .|::.||||:.::.:.....||:...||..|..||||::.:...|::|
Zfish  1215 DVLPPDRALAFLVTTE-GESNNYINAALMDSFHRPAAFIVTPHPLPGTTSDFWRLVFDYGCTSVV 1278

  Fly  1286 MISEI--GDGPRKCPRYWADDEV-QYDHILVKYVHSESCPYYTRREFYVTNCK--IDDTLKVTQF 1345
            |::::  .:....|.:||.:..: ||..:.|:::...:......|.|.|.|..  .:..|.|.||
Zfish  1279 MLNQLNQSNSAWPCVQYWPEPGLQQYGPMQVEFLSMSADEDIITRLFRVKNVTRLQEGQLVVCQF 1343

  Fly  1346 QYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNSGCRSPLT-VHCSLGTDRSSIFVAMCILVQ 1409
            |:..| :...:||:..:..:.|:.......:.     |....| |||..|..||..:.|..||::
Zfish  1344 QFLRW-SAYRDVPDSKKAFLNLLASVQKWQRE-----CGEGRTVVHCLNGGGRSGTYCASNILME 1402

  Fly  1410 HLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINYSD 1452
            .::.:..||:....:.||:.:..::.:..||.|.:..::.|.|
Zfish  1403 MIQYQNIVDVFYAVKTLRNAKPNMVETLEQYRFCYELVLEYLD 1445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653	20/119 (17%)
		Ig	150..221	CDD:143165	16/96 (17%)
		fn3	237..321	CDD:278470	19/91 (21%)
		FN3	339..432	CDD:238020	22/118 (19%)
		FN3	439..535	CDD:238020	24/97 (25%)
		PTPc	892..1155	CDD:214550	94/268 (35%)
		PTPc	920..1155	CDD:238006	85/240 (35%)
		PHA02694	<1121..1206	CDD:177476	24/86 (28%)
		PTPc	1186..1449	CDD:214550	69/269 (26%)
		PTPc	1216..1449	CDD:238006	62/238 (26%)
ptprub	XP_009290693.1	MAM	26..184	CDD:279023	25/113 (22%)
		MAM	26..182	CDD:99706	24/111 (22%)
		IG_like	192..278	CDD:214653	14/88 (16%)
		FN3	282..353	CDD:214495	16/74 (22%)
		FN3	384..480	CDD:238020	20/106 (19%)
		FN3	489..584	CDD:238020	26/104 (25%)
		Y_phosphatase	912..1147	CDD:278528	85/242 (35%)
		PTPc	923..1147	CDD:238006	83/231 (36%)
		PTPc	1179..1442	CDD:214550	69/269 (26%)
		PTPc	1209..1442	CDD:238006	62/239 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910