DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp69D and Ptprm

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_038939045.1	Gene:	Ptprm / 29616	RGDID:	620776	Length:	1531	Species:	Rattus norvegicus

Alignment Length:	1495	Identity:	367/1495 - (24%)
Similarity:	607/1495 - (40%)	Gaps:	305/1495 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 FIKYKNVLALLDVNIKDSGNYTCTAQTGQNHSTEFQVRPYLPSKVLQSTPDRIKRKIKQDVMLYC 154
            |::.:||    :||......:.|:|                           |.|.:..|
  Rat   204 FLRIQNV----EVNAGQFATFQCSA---------------------------IGRTVAGD----- 232

  Fly   155 LIEMYPQN-ETTNRNLKWLKDGSQFEFLDTFSSISKLNDTHLNFTLEFTEVYKKENGTYKCTVFD 218
              .::.|. :..:..||.:|..|...|:.:|:.:   |.|            |::.|.|:|.:..
  Rat   233 --RLWLQGIDVRDAPLKEIKVTSSRRFIASFNVV---NTT------------KRDAGKYRCMIRT 280

  Fly   219 DTGLEITSKEITLFVMEVP-QVSIDFAKAVGANKIYLNWTVN--DGNDPIQKFFITLQEAGTPTF 280
            :.|:.| |....|.|.|.| .::.....:|||..:::....|  :|:.|     |..:|....|
  Rat   281 EGGVGI-SNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP-----IVAREVEYCT- 338

  Fly   281 TYHKDFINGS--------HTSYILDHFKPNTTYFLRIV----GKNSIGNGQPTQYPQGITTLSYD 333
                  .:||        .|||.:.|..|:|.|.:.::    |:...|:..|....:   |...|
  Rat   339 ------ASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTR---TKCAD 394

  Fly   334 PIFIP-KVETTGSTASTITIGWNPPPPDLIDY----IQYYELIVS---ESGEVPKVIEEAIYQQN 390
            |:..| |:|.....:..|||.|.|     ..|    ...|.|.|.   :.|...:|.||..:..:
  Rat   395 PMRGPRKLEVVEVKSRQITIRWEP-----FGYNVTRCHSYNLTVRYCYQVGGQEQVREEVSWDMD 454

  Fly   391 SRNLPYMFDKLKTATD----------------YEFRVRACSDLTKTCGPWSENVNGTTMDGVATK 439
            :.:..:....|...|:                .|..|:...||.....  :|::.|:..:
  Rat   455 NSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELTVQTDEDLPGAVP--TESIQGSAFE----- 512

  Fly   440 PTNLSIQCHHDNVTRGNSIAINWDVPKTPNGKVVSYLIHLLGNPMSTVDREM----WGPKIRRID 500
                            ..|.:.|..|....|.:..|  .:....:|:.|.|:    ...::.::.
  Rat   513 ----------------EKIFLQWREPTQTYGVITLY--EITYKAVSSFDPEIDLSNQSGRVSKLG 559

  Fly   501 EPHHKTLYESVSPNTNYTVTVSAITRHKKNGEPATGSCLMPVSTPDAIGRTMWSKVNLDSKYVLK 565
            ...| .|:..:.|.|.|:.|:.|.|. |..|.|||......:|.|........:.:|.....|..
  Rat   560 NETH-FLFFGLYPGTTYSFTIRASTA-KGFGPPATNQFTTKISAPSMPAYEFETPLNQTDNTVTV 622

  Fly   566 LYLPKISERNGPICCYRLYLVRINNDNKELPDPEKLNIATYQ----EVHSDNVTRSSAYIAEMIS 626
            |..|..| |..|:..|::.:      .:|.|...|......:    .:|..|        |.:::
  Rat   623 LLKPAQS-RGAPVSVYQIVV------EEERPRRTKKTTEILKCYPVPIHFQN--------ASILN 672

  Fly   627 SKYFRPEIF------------LGDEKRFSE--NNDII-------------RDNDEICRKCLE--- 661
            |:|:....|            :||.|.::.  |..::             |.|.|....|:.
  Rat   673 SQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPHKSYRIYYQAASRANGETKIDCVRVAT 737

  Fly   662 ---------GTPFLRKPEIIHIPP---QGSLSNSDSELPILSEKDNLIKGANLTEHALKI----- 709
                     .||::|      |.|   .|.|:.:.:..|:...:    ||   |:|.:||
  Rat   738 KAAIIVTQLTTPYIR------IAPAAGDGQLTGAVTPKPVPEPE----KG---TDHTVKIAGVIA 789

  Fly   710 ---------LESKLRDKRNAVTSDENPILSAVNPNVPLHDSSRDVFDGEIDINSNYTGFLEIIVR 765
                     |...|..|:..:.......:|:....:.:..:|.|....|...|.: ..|..:...
  Rat   790 GILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCD-EAFSFMDTH 853

  Fly   766 DRNNALMAYSKYFDIITPATEAEPIQSLNNMDYYLSIGVKAGAVLLGVILVFIVLWVFHHKKTKN 830
            :.|...::....|.:.|.....    |:.| .||..              .|:...:...::|:.
  Rat   854 NLNGRSVSSPSSFTMKTNTLST----SVPN-SYYPD--------------PFVPTAILGAQQTRL 899

  Fly   831 ELQ-GEDTLTL-RDSLSRALFGRRNHNHSHFITSGNHKGFDAGPIHR----LDLENAYKNRHKDT 889
            .:. .::|.|: .|:.|.|      ..|::.........:..|.:|.    .||...........
  Rat   900 SVPINDETHTMASDTSSLA------QPHTYKKREAADVPYQTGQLHPAIRVADLLQHITQMKCAE 958

  Fly   890 DYGFLREYEMLPNRFSDRTTKNSDLK--ENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANF 952
            .|||..|||..   |..::......|  ||..||||.:|.|||.:||:|.::.|..::||||.|:
  Rat   959 GYGFKEEYESF---FEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQMLEGDNSSDYINGNY 1020

  Fly   953 VIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFG 1017
            :.||.....:|..||||:.|:.|||||:|.::...|:|:|||.|..:.||.||||:   ||:.:.
  Rat  1021 IDGYHRPNHYIATQGPMQETVYDFWRMVWYENTASIIMVTNLVEVGRVKCCKYWPD---DTEIYK 1082

  Fly  1018 DILVKFAQERKTGDYIERTLNVSKNKANVGEE-------------EDRRQITQYHYLTWKDFMAP 1069
            ||.|.........:|:.||..|.|..|. ||.             .:.|:|.|:|:..|.|...|
  Rat  1083 DIKVTLIDTELLAEYVIRTFAVEKGGAG-GEANCSPSREVPQRGIHEIREIRQFHFTGWPDHGVP 1146

  Fly  1070 EHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRH 1134
            .|..|::.|:||:.|......||::||||||.||||..:.:|.::...|.|..|.|||.|.:||.
  Rat  1147 YHATGLLGFVRQVKSKSPPNAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRS 1211

  Fly  1135 QRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESL-----KRKPNEGKCKLEVEFEKL 1194
            :|..:||:.:||:|::.|:|:....|:|.|    .||.:.||     |..|.....:::.||..|
  Rat  1212 RRVNMVQTEEQYVFIHDAILEACLCGDTSI----PASQVRSLYYDMNKLDPQTNSSQIKEEFRTL 1272

  Fly  1195 -LATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETF 1258
             :.|.....:.||:.....|:.|||..:|:|.||....|..:. .|:|.||||:.::.|.....|
  Rat  1273 NMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITID-GESSNYINAALMDSYKQPSAF 1336

  Fly  1259 IIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPRKCPRYWADDEV-QYDHILVKYVHSESCP 1322
            |:.|.||.||:.||||::.:...|::||:::: |..:.||:||.::.| ::..|.|::|.::...
  Rat  1337 IVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDV-DPTQLCPQYWPENGVHRHGPIQVEFVSADLEE 1400

  Fly  1323 YYTRREFYVTNCK--IDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNSGCRS 1385
            ....|.|.:.|..  .|....|.|||:.||| :..:.|...|..::|:.|. :.::...|.| ..
  Rat  1401 DIISRIFRIYNASRPQDGHRMVQQFQFLGWP-MYRDTPVSKRSFLKLIRQV-DKWQEEYNGG-EG 1462

  Fly  1386 PLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY 1450
            ...|||..|..||..|.|:.|:.:.||.::.||:....:.||:.:..:::...||:|.:...:.|
  Rat  1463 RTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY 1527

Fly 1451 1450
Rat 1528 1527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653	20/94 (21%)
		Ig	150..221	CDD:143165	13/71 (18%)
		fn3	237..321	CDD:278470	21/98 (21%)
		FN3	339..432	CDD:238020	23/115 (20%)
		FN3	439..535	CDD:238020	19/99 (19%)
		PTPc	892..1155	CDD:214550	107/277 (39%)
		PTPc	920..1155	CDD:238006	98/247 (40%)
		PHA02694	<1121..1206	CDD:177476	28/90 (31%)
		PTPc	1186..1449	CDD:214550	80/266 (30%)
		PTPc	1216..1449	CDD:238006	73/235 (31%)
Ptprm	XP_038939045.1	FN3	298..377	CDD:214495	20/90 (22%)
		FN3	399..493	CDD:238020	20/98 (20%)
		fn3	515..590	CDD:394996	18/78 (23%)
		R-PTPc-M-1	946..1235	CDD:350481	111/295 (38%)
		R-PTPc-M-2	1321..1526	CDD:350483	63/208 (30%)
		MAM	42..198	CDD:214533
		ig	208..290	CDD:395002	25/135 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810