DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp69D and Ptprz1

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	NP_037212.2	Gene:	Ptprz1 / 25613	RGDID:	3455	Length:	2316	Species:	Rattus norvegicus

Alignment Length:	1567	Identity:	371/1567 - (23%)
Similarity:	612/1567 - (39%)	Gaps:	426/1567 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 GNQTINKNH-----------TRYKIRTEPLKSNDD--GSENNDSQDFIKYKNVLALLD----VNI 104
            |:..||.:|           |...::..|..|.|.  ...::||:..:...:.|..|:    |::
  Rat   968 GSLLINPSHISLPESSFITPTASLLQLPPALSGDGEWSGASSDSELLLPDTDGLRTLNMSSPVSV 1032

  Fly   105 KDSGNYTCTAQTGQNHSTEFQVRPYLPSKVLQSTPDRIKRKIKQDVMLYCLIEMYPQNETTNRNL 169
            .|. .|| |:.:|.:      ::|....:::......:|.....|:       .||...|....:
  Rat  1033 ADF-TYT-TSVSGDD------IKPLSKGEMMYGNETELKMSSFSDM-------AYPSKSTVVPKM 1082

  Fly   170 -----KWLKDGSQFEFLDTFSSISKLNDTHLNFTLEFTEVYKKENGTYKCT-VFDDTGLEITSKE 228
                 ||.:     ...:|..|:|.:|..       ||     |:..|..| |||        :|
  Rat  1083 SDIVNKWSE-----SLKETSVSVSSINSV-------FT-----ESLVYPITKVFD--------QE 1122

  Fly   229 ITLFVMEVPQVSIDFAKAVGANKIYLNWTVNDGNDPIQKFFITLQEAGTPTF-----TYHKDFIN 288
            |:    .||::..                      |::......|.:|....     |..:..::
  Rat  1123 IS----RVPEIIF----------------------PVKPTHTASQASGDTWLKPGLSTNSEPALS 1161

  Fly   289 GSHTSYILDHFKPNTTYFLRIVGKNSIGNGQPTQYPQGITTLSYDPIFIPK-----VETTGSTAS 348
            .:.:|.:|   .|:|               ||..| :..:..:.:.:..|.     |:|...||
  Rat  1162 DTASSEVL---HPST---------------QPLLY-EAASPFNTEALLQPSFPASDVDTLLKTA- 1206

  Fly   349 TITIGWNPPPPDLIDYIQYYELIVSESGEVPKVIEEAIYQQNSRNLPYMFDKLKTATDYEFRVRA 413
               :...|..|.|.              |.|.|.:.:    :|.:||...:...:.:...|....
  Rat  1207 ---LPSGPRDPVLT--------------ETPMVEQSS----SSMSLPLASESASSKSTLHFTSVP 1250

  Fly   414 CSDLTKTCGPWSENVNGTTMDGV----------------ATKPTNLSIQCH-HDNVTRGNSIAIN 461
            ..:::.:      :|:.|::..:                :..|..:....| ||...:...:.|:
  Rat  1251 VLNMSPS------DVHPTSLQRLTVPHSREEYFEQGLLKSKSPQQVLPSLHSHDEFFQTAHLDIS 1309

  Fly   462 WDVPKTPNGKVVSYLIHLLGNPMSTVDREMWGPKIRRIDEPHH----KTLY-ESVSPNTNYTVTV 521
            ...|  |.|:      |....|            |..||||.:    :.:| |.:..:...::|.
  Rat  1310 QAYP--PKGR------HAFATP------------ILSIDEPQNTLISRLVYSEDIFMHPEISITD 1354

  Fly   522 SAITRHKKNGEPATGSCLMPVSTPDA-------IGRTMWSKVNLDSKYVLKLYLPKISERNGPIC 579
            .|:|     |.|.|.|.:: ::|..:       |..|..|....||....||.||
  Rat  1355 KALT-----GLPTTVSDVL-IATDHSVPLGSGPISMTTVSPNRDDSVTTTKLLLP---------- 1403

  Fly   580 CYRLYLVRINNDNKELPDPEKLNIATYQEVHSDNVTRSSAYIAEMISSKYFRPEIFLGDEKRFSE 644
                                  :.||.:..||   .||.   |:::.....      ||:....:
  Rat  1404 ----------------------SKATSKPTHS---ARSD---ADLVGGGED------GDDYDDDD 1434

  Fly   645 NNDIIRDNDEI-CRKCLEGTPFLRKPEIIHIPPQGSLSNSDSELPILSEKDNLIKGANLTEHALK 708
            .:||  |:|.. ..||:..:|:....|.:       :::||      :::.:|:..::...|.|
  Rat  1435 YDDI--DSDRFPVNKCMSCSPYRESQEKV-------MNDSD------TQESSLVDQSDPISHLL- 1483

  Fly   709 ILESKLRDKRNAVTS--------DENP-------------------ILSAVNPNVP--------L 738
               |:..::.|..|.        |::|                   :.|||.|:.|        .
  Rat  1484 ---SENTEEENGGTGVTRVDKSPDKSPPPSMLPQKHNDGREDRDIQMGSAVLPHTPGSKAWAVLT 1545

  Fly   739 HDSSRDVFDGEID-INSNYT----GFLEIIVRDRNNALMA----------------YSKYFDIIT 782
            .|.......|..| :|.|.|    .|.::..:|.:..|.|                .:.....::
  Rat  1546 SDEESGSGQGTSDSLNDNETSTDFSFPDVNEKDADGVLEADDTGIAPGSPRSSTPSVTSGHSGVS 1610

  Fly   783 PATEAEPIQSLNNMDYYLSIGVKAG------AVLLGVI---LVFIVLWVFHHKKTKNELQGEDTL 838
            .::|||    .:|..:...||:..|      ||:..||   |.||.|.|.
  Rat  1611 NSSEAE----ASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVL--------------- 1656

  Fly   839 TLRDSLSRALFGRRNHNHSHFITSGNHK--------------GFDAG-------PIHRLDLENAY 882
                 :...::.|:....:||....|..              ..|.|       |.|..||.
  Rat  1657 -----VGILIYWRKCFQTAHFYLEDNTSPRVISTPPTPIFPISDDIGAIPIKHFPKHVADLH--- 1713

  Fly   883 KNRHKDTDYGFLREYEMLPNRFSD---------RTTKNSDLKENACKNRYPDIKAYDQTRVKLAV 938
                  ...||..|:|.|...:.:         .|..:|:..:|..||||.:|.|||.:||||..
  Rat  1714 ------ASNGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYVNIVAYDHSRVKLTQ 1772

  Fly   939 I---NGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKA 1000
            :   :| :.|||||||:|.||...|.:|.||||::||.:||||||||.::|:|||:|||.|..:.
  Rat  1773 LAEKDG-KLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRR 1836

  Fly  1001 KCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDR---RQITQYHYLT 1062
            ||.:|||..  .::::|..||.....:....|..|...:...|...|.::.|   |.:|||||..
  Rat  1837 KCDQYWPTD--GSEEYGSFLVNQKNVQVLAYYTVRNFTLRNTKIKKGSQKGRSSGRLVTQYHYTQ 1899

  Fly  1063 WKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYN 1127
            |.|...||:...::.|:|:.........||::||||||||||||.:.|||::||::.|.:|:|:.
  Rat  1900 WPDMGVPEYSLPVLAFVRKTAQAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFG 1964

  Fly  1128 TVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKRKPNEGKCKLEVEFE 1192
            .:..:|.|||:|||:.:||:|::..|::......|::....:.|.:.:|......||.|||.:|:
  Rat  1965 FLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVPDSHIHSYVNTLLIPGPSGKTKLEKQFQ 2029

  Fly  1193 KLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSET 1257
             ||:.::.:....|....:.|..|||:..|||.:|:||.::.| ..|.:.|||||:|.||..|..
  Rat  2030 -LLSQSNILQSDYSTALKQCNREKNRTSSIIPVERSRVGISSL-SGEGTDYINASYIMGYYQSNE 2092

  Fly  1258 FIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPRKCPR---YW--ADDEVQYDHILVKYVH 1317
            |||.|.||.:||.||||||.:.:...:|||.   ||......   ||  .|:.:..:...|..:.
  Rat  2093 FIITQHPLLHTIKDFWRMIWDHNAQLVVMIP---DGQNMAEDEFVYWPNKDEPINCESFKVTLMS 2154

  Fly  1318 SE-SCPYYTRR----EFYVTNCKIDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKN 1377
            .| .|.....:    :|.:...:.|..|:|..||...||..|..:.:....|..:.::|.|.
  Rat  2155 EEHKCLSNEEKLIVQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISIIKEEAANR--- 2216

  Fly  1378 NKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEF 1442
                  ..|:.||...|...:..|.|:..|:..|..|..:|:....:.:...|.|:.....||:|
  Rat  2217 ------DGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSMDVYQVAKMINLMRPGVFTDIEQYQF 2275

  Fly  1443 LHRAIIN 1449
            |::.:::
  Rat  2276 LYKVVLS 2282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653	21/99 (21%)
		Ig	150..221	CDD:143165	17/76 (22%)
		fn3	237..321	CDD:278470	10/88 (11%)
		FN3	339..432	CDD:238020	15/97 (15%)
		FN3	439..535	CDD:238020	22/101 (22%)
		PTPc	892..1155	CDD:214550	113/277 (41%)
		PTPc	920..1155	CDD:238006	105/240 (44%)
		PHA02694	<1121..1206	CDD:177476	24/84 (29%)
		PTPc	1186..1449	CDD:214550	81/272 (30%)
		PTPc	1216..1449	CDD:238006	73/242 (30%)
Ptprz1	NP_037212.2	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..401	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..537
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	586..624
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1141..1172		5/33 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1228		8/45 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1401..1521		29/182 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1545..1622		14/80 (18%)
		PTPc	1717..1992	CDD:214550	113/277 (41%)
		PTPc	1753..1992	CDD:238006	105/241 (44%)
		Substrate binding. /evidence=ECO:0000250	1934..1940		5/5 (100%)
		PTPc	2023..2281	CDD:214550	81/271 (30%)
		PTPc	2051..2281	CDD:238006	73/242 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010