DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp69D and Ptprz1

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_006505075.1	Gene:	Ptprz1 / 19283	MGIID:	97816	Length:	2318	Species:	Mus musculus

Alignment Length:	1571	Identity:	364/1571 - (23%)
Similarity:	594/1571 - (37%)	Gaps:	432/1571 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 GNQTINKNH-----------TRYKIRTEPLKSNDD--GSENNDSQDFIKYKNVLALLDVNIKDS- 107
            |:..||.:|           |...::..|..|.|.  ...::||:..:...:.|..|:::...|
Mouse   968 GSLLINPSHISMPESSFITPTASLLQPPPALSGDGEWSGASSDSELLLPDADGLRTLNISSPVSV 1032

  Fly   108 GNYTCTAQTGQNHSTEFQVRPYLPSKVLQSTPDRIKRKIKQDVMLYCLIEMYPQNETTNRNL--- 169
            ..:|.|.....:     .::|...|:::......:|.....|:       .||...|....:
Mouse  1033 AEFTYTTSVFAD-----GIKPLSKSEMMYGNETELKMSSFSDM-------AYPSKSTVVPKMSDV 1085

  Fly   170 --KWLKDGSQFEFLDTFSSISKLNDTHLNFTLEFTEVYKKENGTYKCTVFDDTGLEITSKEITLF 232
              ||.:     ...:|..|||.:.                       :||.::.:..|:|.....
Mouse  1086 VHKWSE-----SLKETSVSISSMK-----------------------SVFPESLVYPTTKGFEQG 1122

  Fly   233 VMEVPQVSIDFAKAVGANKIYLNWTVNDGNDPIQKFFITLQEAGTP--------------TFTYH 283
            |..||::..                      |:|......|.:|..              :.|..
Mouse  1123 VSHVPEIIF----------------------PVQPTHTASQASGDTWLKPGLSANSEAAFSDTAS 1165

  Fly   284 KDFINGSHTSYILDHFKP-NTTYFLRIVGKNSIGNGQPTQYPQGITTL--------SYDPIF--I 337
            ::.::.|....:.:...| ||...|           ||:.....:.||        ..|||.  .
Mouse  1166 REVVHPSTQPLLYEAATPFNTEALL-----------QPSFQASDVDTLLKTALPSVPSDPILAGT 1219

  Fly   338 PKVETTGSTASTITIGWNPPPPDLIDYIQYYELIVSESGEVPKVIEEAIYQQNSRNLPYMFDKLK 402
            |:||.:.|:.|      :|              :.||||....::       :..::|.:
Mouse  1220 PQVEQSSSSVS------HP--------------MASESGSSESML-------HFTSVPIL----- 1252

  Fly   403 TATDYEFRVRACSDLTKTCGPWSENVNGTTMDGVATKPTN-----------------LSIQCHHD 450
                         |::.:      .|:.|.:.|:....::                 |.....:|
Mouse  1253 -------------DISPS------KVHSTPLQGLTVPHSSKKFSEQGLLKSKSPQQVLPSLFSND 1298

  Fly   451 NVTRGNSIAINWDVPKTPNGKVVSYLIHLLGNPMSTVDREMWGPKIRRIDEPH----HKTLY-ES 510
            ...:...:.::...|  |.|:      |....|            :..||||.    :|.:| |.
Mouse  1299 EFFQSAHLDVSQAYP--PKGR------HAFVTP------------VLSIDEPQNTLINKLVYSED 1343

  Fly   511 VSPNTNYTVTVSAITRHKKNGEPATGSCLMPVSTPD--------AIGRTMWSKVNLDSKYVLKLY 567
            :..:|..::|...:|     |.|...|.::  |:.|        .|..||.|....||....||.
Mouse  1344 IFSSTEISITDKVLT-----GLPTLASDVL--SSTDHSVPLGSGPISLTMVSPNRDDSVTTAKLL 1401

  Fly   568 LPKISERNGPICCYRLYLVRINNDNKELPDPEKLNIATYQEVHSDNVTRSSAYIAEMISSKYFRP 632
            ||..:                                      :..:|:|:...|:::.
Mouse  1402 LPSTA--------------------------------------TSKLTQSARSDADLVG------ 1422

  Fly   633 EIFLGDEKRFSENNDIIRDNDEICR------KCLEGTPFLRKPEII----HIPPQGSLSNSDSEL 687
                |.|.....::|   |.|:|.|      ||:...|:....|.:    .......:..||...
Mouse  1423 ----GGEDGDDYDDD---DYDDIDRGRFPVNKCMSCLPYRESREKVMNDSDTQESSLVDQSDPIS 1480

  Fly   688 PIL---SEKDNLIKGANLTEHALKILESKLRDKRNAVTSDEN-PILSAVNPNVP--------LHD 740
            |:|   :|::|  .|..:|........|.|....|....|.: .:.|||.|:.|        ..|
Mouse  1481 PLLFENTEEEN--GGTGVTRVDKSPPPSMLPQNHNDGKEDSDIQMGSAVLPHTPGSKAWAVLTSD 1543

  Fly   741 SSRDVFDGEID-INSNYT----GFLEIIVRDRNNAL----------------MAYSKYFDIITPA 784
            .......|..| :|.|.|    .|.::..:|.:..|                .:.:.....::.:
Mouse  1544 EESGSGQGTSDSLNDNETSTDFSFPDVNEKDTDGVLETDDTGIAPGSPRSSTPSVTSGHSGVSNS 1608

  Fly   785 TEAEPIQSLNNMDYYLSIGVKAG------AVLLGVI---LVFIVLWVFHHKKTKNELQGEDTLTL 840
            :|||    .:|..:...||:..|      ||:..||   |.||.|.|.
Mouse  1609 SEAE----ASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVL----------------- 1652

  Fly   841 RDSLSRALFGRRNHNHSHFITSGNHK--------------GFDAG-------PIHRLDLENAYKN 884
               :...::.|:....:||....|..              ..|.|       |.|..||.
Mouse  1653 ---VGILIYWRKCFQTAHFYLEDNTSPRVISTPPTPIFPISDDIGAIPIKHFPKHVADLH----- 1709

  Fly   885 RHKDTDYGFLREYEMLPNRFSDRTTKNSDL---------KENACKNRYPDIKAYDQTRVKLAVI- 939
                ...||..|:|.|...:.:..:..:||         .:|..||||.:|.|||.:||||..:
Mouse  1710 ----ASNGFTEEFETLKEFYQEVQSCTADLGITADSSNHPDNKHKNRYVNIVAYDHSRVKLTQLA 1770

  Fly   940 --NGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKC 1002
              :| :.|||||||:|.||...|.:|.||||::||.:||||||||.::|:|||:|||.|..:.||
Mouse  1771 EKDG-KLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKC 1834

  Fly  1003 AKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKAN------VGEEEDR---RQITQY 1058
            .:|||..  .::::|..||.....:....|..|...:...|..      .|.::.|   |.:|||
Mouse  1835 DQYWPTD--GSEEYGSFLVNQKSVQVLAYYTVRNFTLRNTKLKKLSELFQGSQKGRSSGRLVTQY 1897

  Fly  1059 HYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSV 1123
            ||..|.|...||:...::.|:|:.........||::||||||||||||.:.|||::||::.|.:|
Mouse  1898 HYTQWPDMGVPEYSLPVLAFVRKAAQAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTV 1962

  Fly  1124 SIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKRKPNEGKCKLE 1188
            :|:..:..:|.|||:|||:.:||:|::..|::......|::....:.|.:.:|......||.|||
Mouse  1963 NIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVPDSHIHSYVNTLLIPGPTGKTKLE 2027

  Fly  1189 VEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYD 1253
            .:|: ||:.::.:....|....:.|..|||:..|||.:|:||.::.| ..|.:.|||||:|.||.
Mouse  2028 KQFQ-LLSQSNILQSDYSTALKQCNREKNRTSSIIPVERSRVGISSL-SGEGTDYINASYIMGYY 2090

  Fly  1254 NSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPRKCPR---YW--ADDEVQYDHILV 1313
            .|..|||.|.||.:||.||||||.:.:...:|||.   ||......   ||  .|:.:..:...|
Mouse  2091 QSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIP---DGQNMAEDEFVYWPNKDEPINCESFKV 2152

  Fly  1314 KYVHSE-SCPYYTRR----EFYVTNCKIDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYN 1373
            ..:..| .|.....:    :|.:...:.|..|:|..||...||..|..:.:....|..:.::|.|
Mouse  2153 TLMSEEHKCLSNEEKLIVQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISIIKEEAAN 2217

  Fly  1374 HYKNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYA 1438
            .         ..|:.||...|...:..|.|:..|:..|..|..:|:....:.:...|.|:.....
Mouse  2218 R---------DGPMIVHDEHGGVTAGTFCALTTLMHQLEKENAMDVYQVAKMINLMRPGVFTDIE 2273

  Fly  1439 QYEFLHRAIIN 1449
            ||:||::.:::
Mouse  2274 QYQFLYKVVLS 2284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653	15/98 (15%)
		Ig	150..221	CDD:143165	11/75 (15%)
		fn3	237..321	CDD:278470	12/98 (12%)
		FN3	339..432	CDD:238020	12/92 (13%)
		FN3	439..535	CDD:238020	19/117 (16%)
		PTPc	892..1155	CDD:214550	113/283 (40%)
		PTPc	920..1155	CDD:238006	105/246 (43%)
		PHA02694	<1121..1206	CDD:177476	24/84 (29%)
		PTPc	1186..1449	CDD:214550	81/272 (30%)
		PTPc	1216..1449	CDD:238006	73/242 (30%)
Ptprz1	XP_006505075.1	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..395	CDD:365830
		PTP_DSP_cys	1714..1997	CDD:391942	112/285 (39%)
		R-PTP-Z-2	2080..2283	CDD:350507	62/214 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010