DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp69D and Ptprm

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	NP_001344554.1	Gene:	Ptprm / 19274	MGIID:	102694	Length:	1486	Species:	Mus musculus

Alignment Length:	1481	Identity:	363/1481 - (24%)
Similarity:	595/1481 - (40%)	Gaps:	306/1481 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 FIKYKNVLALLDVNIKDSGNYTCTAQTGQNHSTEFQVRPYLPSKVLQSTPDRIKRKIKQDVMLYC 154
            |::.:||    :||......:.|:|                           |.|.:..|
Mouse   188 FLRIQNV----EVNAGQFATFQCSA---------------------------IGRTVAGD----- 216

  Fly   155 LIEMYPQN-ETTNRNLKWLKDGSQFEFLDTFSSISKLNDTHLNFTLEFTEVYKKENGTYKCTVFD 218
              .::.|. :..:..||.:|..|...|:.:|:.:   |.|            |::.|.|:|.:..
Mouse   217 --RLWLQGIDVRDAPLKEIKVTSSRRFIASFNVV---NTT------------KRDAGKYRCMICT 264

  Fly   219 DTGLEITSKEITLFVMEVP-QVSIDFAKAVGANKIYLNWTVN--DGNDPIQKFFITLQEAGTPTF 280
            :.|:.| |....|.|.|.| .::.....:|||..:::....|  :|:.|     |..:|....|
Mouse   265 EGGVGI-SNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGP-----IVAREVEYCT- 322

  Fly   281 TYHKDFINGS--------HTSYILDHFKPNTTYFLRIV----GKNSIGNGQPTQYPQGITTLSYD 333
                  .:||        .|||.:.|..|:|.|.:.::    |:...|:..|....:   |...|
Mouse   323 ------ASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTR---TKCAD 378

  Fly   334 PIFIP-KVETTGSTASTITIGWNPPPPDLIDY----IQYYELIVS---ESGEVPKVIEEAIYQQN 390
            |:..| |:|.....:..|||.|.|     ..|    ...|.|.|.   :.|...:|.||..:..:
Mouse   379 PMRGPRKLEVVEVKSRQITIRWEP-----FGYNVTRCHSYNLTVHYGYQVGGQEQVREEVSWDTD 438

  Fly   391 SRNLPYMFDKLKTATD----------------YEFRVRACSDLTKTCGPWSENVNGTTMDGVATK 439
            :.:..:....|...|:                .|..|:...||.....  :|::.|:..:
Mouse   439 NSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELTVQTDEDLPGAVP--TESIQGSAFE----- 496

  Fly   440 PTNLSIQCHHDNVTRGNSIAINWDVPKTPNGKVVSYLIHLLGNPMSTVDREM----WGPKIRRID 500
                            ..|.:.|..|....|.:..|  .:....:|:.|.|:    ...::.::.
Mouse   497 ----------------EKIFLQWREPTQTYGVITLY--EITYKAVSSFDPEIDLSNQSGRVSKLG 543

  Fly   501 EPHHKTLYESVSPNTNYTVTVSAITRHKKNGEPATGSCLMPVSTPDAIGRTMWSKVNLDSKYVLK 565
            ...| .|:..:.|.|.|:.|:.|.|. |..|.|||......:|.|........:.:|.....|..
Mouse   544 NETH-FLFFGLYPGTTYSFTIRASTA-KGFGPPATNQFTTKISAPSMPAYEFETPLNQTDNTVTV 606

  Fly   566 LYLPKISERNGPICCYRLYLVRINNDNKELPDPEKLNIATYQ----EVHSDNVTRSSAYIAEMIS 626
            :..|..| |..|:..|::.:      .:|.|...|......:    .:|..|        |.:::
Mouse   607 MLKPAQS-RGAPVSVYQIVV------EEERPRRTKKTTEILKCYPVPIHFQN--------ASILN 656

  Fly   627 SKYFRPEIF------------LGDEKRFSE--NNDII-------------RDNDEICRKCLE--- 661
            |:|:....|            :||.|.::.  |..::             |.|.|....|:.
Mouse   657 SQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPHKSYRIYYQAASRANGETKIDCVRVAT 721

  Fly   662 ---------GTPFLRKPEIIHIPP---QGSLSNSDSELPILS-EKDNLIKGANLTEHALKI---- 709
                     .||::|      |.|   .|.|:.:.:..|:.. ||.        |:|.:||
Mouse   722 KAAIIVTQLTTPYIR------IAPAAGDGQLTGAVTPKPVPEPEKQ--------TDHTVKIAGVI 772

  Fly   710 ----------LESKLRDKRNAVTSDENPILSAVNPNVPLHDSSRDVFDGEIDINSNYTGFLEIIV 764
                      |...|..|:..:.......:|:....:.:..:|.|....|...|.: ..|..:..
Mouse   773 AGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCD-EAFSFMGT 836

  Fly   765 RDRNNALMAYSKYFDIITPATEAEPIQSLNNMDYYLSIGVKAGAVLLGVILVFIVLWVFHHKKTK 829
            .:.|...::....|.:.|.....    |:.| .||....|.. |:|                 .:
Mouse   837 HNLNGRSVSSPSSFTMKTNTLST----SVPN-SYYPDPFVPT-AIL-----------------DE 878

  Fly   830 NELQGEDTLTLRDSLSRALFGRRNHNHSHFITSGNHKGFDAGPIHR----LDLENAYKNRHKDTD 890
            ......||.:|...            |::.........:..|.:|.    .||............
Mouse   879 THTMASDTSSLAQP------------HTYKKREAADVPYQTGQLHPAIRVADLLQHITQMKCAEG 931

  Fly   891 YGFLREYEMLPNRFSDRTTKNSDLK--ENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFV 953
            |||..|||..   |..::......|  ||..||||.:|.|||.:||:|.::.|...:||||.|::
Mouse   932 YGFKEEYESF---FEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQMLEGDNNSDYINGNYI 993

  Fly   954 IGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGD 1018
            .||.....:|..||||:.||.|||||:|.::...|:|:|||.|..:.||.||||:   ||:.:.|
Mouse   994 DGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD---DTEIYKD 1055

  Fly  1019 ILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQIN 1083
            |.|.........:|:.||..|.|...:     :.|:|.|:|:..|.|...|.|..|::.|:||:.
Mouse  1056 IKVTLIDTELLAEYVIRTFAVEKRGIH-----EIREIRQFHFTGWPDHGVPYHATGLLGFVRQVK 1115

  Fly  1084 SVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIF 1148
            |......||::||||||.||||..:.:|.::...|.|..|.|||.|.:||.:|..:||:.:||:|
Mouse  1116 SKSPPNAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVF 1180

  Fly  1149 LYRALLDTGTFGNTDICIDTMASAIESL-----KRKPNEGKCKLEVEFEKL-LATADEISKSCSV 1207
            ::.|:|:....|:|.|    .||.:.||     |..|.....:::.||..| :.|.....:.||:
Mouse  1181 IHDAILEACLCGDTSI----PASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSI 1241

  Fly  1208 GENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDF 1272
            .....|:.|||..:|:|.||....|..:. .|:|.||||:.::.|.....||:.|.||.||:.||
Mouse  1242 ALLPRNHEKNRCMDILPPDRCLPFLITID-GESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1305

  Fly  1273 WRMISEQSVTTLVMISEIGDGPRKCPRYWADDEV-QYDHILVKYVHSESCPYYTRREFYVTNCK- 1335
            ||::.:...|::||:::: |..:.||:||.::.| ::..|.|::|.::.......|.|.:.|..
Mouse  1306 WRLVLDYHCTSVVMLNDV-DPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNASR 1369

  Fly  1336 -IDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNSGCRSPLTVHCSLGTDRSS 1399
             .|....|.|||:.||| :..:.|...|..::|:.|. :.::...|.| .....|||..|..||.
Mouse  1370 PQDGHRMVQQFQFLGWP-MYRDTPVSKRSFLKLIRQV-DKWQEEYNGG-EGRTVVHCLNGGGRSG 1431

  Fly  1400 IFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY 1450
            .|.|:.|:.:.||.::.||:....:.||:.:..:::...||:|.:...:.|
Mouse  1432 TFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEY 1482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653	20/94 (21%)
		Ig	150..221	CDD:143165	13/71 (18%)
		fn3	237..321	CDD:278470	21/98 (21%)
		FN3	339..432	CDD:238020	23/115 (20%)
		FN3	439..535	CDD:238020	19/99 (19%)
		PTPc	892..1155	CDD:214550	105/264 (40%)
		PTPc	920..1155	CDD:238006	96/234 (41%)
		PHA02694	<1121..1206	CDD:177476	28/90 (31%)
		PTPc	1186..1449	CDD:214550	80/266 (30%)
		PTPc	1216..1449	CDD:238006	73/235 (31%)
Ptprm	NP_001344554.1	MAM	22..182	CDD:214533
		ig	192..274	CDD:278476	25/135 (19%)
		FN3	282..361	CDD:214495	20/90 (22%)
		FN3	383..467	CDD:214495	18/88 (20%)
		fn3	499..574	CDD:306538	18/78 (23%)
		PTPc	933..1187	CDD:214550	105/264 (40%)
		PTPc	1249..1481	CDD:238006	73/236 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810