DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp69D and T04F3.3

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	NP_505965.2	Gene:	T04F3.3 / 188063	WormBaseID:	WBGene00011438	Length:	364	Species:	Caenorhabditis elegans

Alignment Length:	385	Identity:	89/385 - (23%)
Similarity:	151/385 - (39%)	Gaps:	116/385 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   834 GEDTLTLRDSLSRALFGRRNHNHSHFITSGNHKGFDAGPIHRLDLENAYKNRHKDTDYGFLREYE 898
            |:.:|:     |.::.|...:|.:..:|||          |.:.||   ||     :|.|
Worm     3 GDGSLS-----SESVIGLHTYNSAADLTSG----------HVMTLE---KN-----EYLF----- 39

  Fly   899 MLPNRFSDRTTKNSDLKENACK------------------------------------------N 921
                   |..||      |||.                                          |
Worm    40 -------DLNTK------NACTRPLDIFIKLLSTSSVGKEFSHFSSLPLSRLRTVDAFFDHPELN 91

  Fly   922 RYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLE 986
            ::.:|:.|:||||:.....|   .:|:|::::.||:|.:|||.|..||..::..|||.:::::..
Worm    92 KFGEIQVYEQTRVRAVHRQG---HNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSL 153

  Fly   987 IIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKT--GDYIERTLNVSKNKANVGEE 1049
            |:|.|..|.: .|.|  .:.|.|:.:.....|:.::....||.  ..| ...|.:|:...
Worm   154 IVVTLCELLD-EKGK--PFVPVKIGEPLVIDDMTIELDNIRKVRPATY-SSVLKISEKGV----- 209

  Fly  1050 EDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSL--------------QRGPILVHCSAG 1100
            |..:.:....|..|.....|:.|..|:..:..:|.:.::              ||.|:.:.|..|
Worm   210 ESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTILRKQGLEKKIFDDSQRTPMTLVCFDG 274

  Fly  1101 VGRTGTLVALDSLIQQLEEEDS-----VSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD 1155
            ..|:.||||||.|.|:|.....     |.|.:|:..||..|.......:|::||..::|:
Worm   275 FSRSCTLVALDILCQRLTASHEIGTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLE 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653
		Ig	150..221	CDD:143165
		fn3	237..321	CDD:278470
		FN3	339..432	CDD:238020
		FN3	439..535	CDD:238020
		PTPc	892..1155	CDD:214550	74/325 (23%)
		PTPc	920..1155	CDD:238006	67/297 (23%)
		PHA02694	<1121..1206	CDD:177476	10/40 (25%)
		PTPc	1186..1449	CDD:214550
		PTPc	1216..1449	CDD:238006
T04F3.3	NP_505965.2	Y_phosphatase	87..334	CDD:278528	67/258 (26%)
T04F3.3	NP_505965.2	PTPc	89..334	CDD:238006	67/256 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910