Protein Alignment Ptp69D and ptrg-1

DIOPT Version :10

• Sequence 1: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Sequence 2: NP_001255470.1
• Gene: ptrg-1 / 177898
• WormBaseID: WBGene00010558
• Length: 1159
• Species: Caenorhabditis elegans
• Alignment Length: 1390
• Identity: 306/1390 - (22%)
• Similarity: 522/1390 - (37%)
• Gaps: 378/1390 - (27%)

  Fly   138 TPDRIKRKIK--QDVMLYCLIEMYPQNETTNRNLKWLKDGSQFEFLDTFSSISKLNDTHLNFTLE 200
            || |:.|::.  ||   ..|:..|.|:...:.:.:|.....:::.:..|            :||.
 Worm    53 TP-RLVRRLDWFQD---DSLVASYQQDILADSSRQWWVSDGRYQLIRPF------------YTLR 101

  Fly   201 FTEVYKKENGTYKCTVFDD----TGLEITSKEITLFVMEVPQVSIDFAKAVGANKIYLNWTVN-- 259
            .:.|..:::|||:|.:..|    :.....::|:.:.|..|...|.:. |......|.|.||.|
 Worm   102 VSPVTPEDSGTYRCRLETDPLFSSPQSTATQELAVMVKPVAPSSPEI-KTFTNRSITLVWTHNAA 165

  Fly   260 DGNDPIQKFFITLQEAGTPTFTYHKDFI---NGSHTSYILDHFKPNTTYFLRIVGKNSIGN---G 318
            ..:.||.:|.::::     |.:.:..|:   ..:.|:.|:|:..|.|.|...:..:||.|:   |
 Worm   166 RAHRPILRFSVSVR-----TVSDNTRFVMAAPSNATTVIVDNLSPYTLYAFSVRAENSAGSSDFG 225

  Fly   319 QPTQYPQGITTLSYDPIFIPKVE-----TTGSTASTITIGWNPPPPDLIDYIQYYELIVSESGEV 378
            ..|.:    .||...|...|:::     |:.....|||      |||            ..:||:
 Worm   226 PETTF----RTLGESPNRPPQIQKIRNITSECVEVTIT------PPD------------EMNGEL 268

  Fly   379 PK--VIEEAIYQQNSRNLPYMFDK----------LKTATDYEFRVRACSDL-----------TKT 420
            .|  |:.:|:.:...|.:  .|||          |..:|||...:.|.:..           |:.
 Worm   269 DKYLVLIQAVNETIPRKM--TFDKPTSTPLTICALSPSTDYALAIEADNGFGTSPQATLVFHTED 331

  Fly   421 CGP-WSENVNGTTMDGVATKPTNLSIQCHHDNVTRGNSIAINWDVPK-TPNGKVVSYLIHLLGNP 483
            ..| ||.:.. ||:. |..||                .|.:.|..|. ....||:.|  ||.
 Worm   332 SVPNWSPSTI-TTLP-VVGKP----------------EITVLWPAPPLNATEKVIKY--HLY--- 373

  Fly   484 MSTVDREMWGPKIRRID-EPH------HKTLYESVSPNTNYTVTVSAITRHKKNGEPATGSCLMP 541
            ....:.:.|  ||..:: .|:      .|.....::|||.|.:.|||.|...:..:.|.......
 Worm   374 YKAKNEDQW--KIEHLNVSPNGVKSKLFKYRLVDLNPNTQYRIRVSASTIKGEGAQSADSVAQTD 436

  Fly   542 VSTPDAIGRTMWSKVNLDSKYVLKL---YLPKISERNGPICCYRLYLVRINNDNKELPDPEKLNI 603
            |..|   |...:..:|.|.|..:||   |.|.::.:..|     .:.|::.|.
 Worm   437 VGEP---GTVTFKDLNFDCKNGVKLRWNYEPSVNSKKSP-----TFTVKVTNQ------------ 481

  Fly   604 ATYQEVHSDNVTRSSAYIAEMISSKYFRPEIFLGDEKRFSENNDIIRDNDEICRKCLEGTPFLRK 668
                       |.|..:...|:|.                   |||
 Worm   482 -----------TTSLQFNTTMLSL-------------------DII------------------- 497

  Fly   669 PEIIHIPPQGSLSNSDSELPILSEKDNLIKGANLTEHALKILESKLRDKRNAVTSDENPILSAVN 733
                      .||..|                   |:.|:|:                 :|
 Worm   498 ----------DLSLYD-------------------EYTLRII-----------------VL---- 512

  Fly   734 PNVPLHDSSRDVFDGEIDINSNYTGFLEIIVRDRNNALMAYSKYFDIITPATEAEPIQSLNNMDY 798
                    .|...|....:...|:...:.|::|:    .:|...|  .:|..:...:.|......
 Worm   513 --------ERSTIDNSTILIGKYSDSHQFILKDK----CSYQSSF--CSPGEKCAKLTSSAGNPR 563

  Fly   799 YLSIGVKAGAVLLGVILVFIVLWVFHHKKTKNELQGEDTLTLRDSLSRALFGRRNHNHSH----- 858
            |:|:.:    |:..:|:...:.:|..|                       |.|.:.|..|
 Worm   564 YISVLI----VIFAIIIFAFICFVIVH-----------------------FARGSMNFKHLLKKK 601

  Fly   859 ----FITSGNHKGFDAGPIHRLDLENAY---KNRHKDTDYGFLREYEMLPNRFS-----DRTTKN 911
                ::...:...:|:.....:.:|..|   ::.:::....|..::::|.::.|     |....|
 Worm   602 EKCVYLEEISPLVYDSAGQEDIPVELFYGYVEDLNRNDSLKFKTQFQILESQTSGIDSVDSGESN 666

  Fly   912 SDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDF 976
            |...||:.||||.:|.|.:.||::|   |.....||||||:|....||..:|..|.|:.||..||
 Worm   667 SSSDENSQKNRYNNIGAIEATRIRL---NSPTGNDYINANYVDSCNERNAYIATQAPLPSTFSDF 728

  Fly   977 WRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSK 1041
            |.|||::...|||.:||:.|..|.||.:|||.:....:.||:..|....|.....:..|.|::..
 Worm   729 WSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNAHFSHRILDLKI 793

  Fly  1042 NKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGT 1106
            .||....|   |::.|.|::.|.|...|.....::.|:...:.::|  .||::|||||||||:|:
 Worm   794 AKAVPAVE---RKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIHS--TGPVVVHCSAGVGRSGS 853

  Fly  1107 LVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMAS 1171
            .:.:||:.:.|.....:::...:..:|.||..|||:|:||||.:.|:......|.|.:..|....
 Worm   854 YILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVHSDLFMR 918

  Fly  1172 AIESLKRKPNEGKCKLEVEFEKLLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLP 1236
            .:..|..:...||.:::::||.:          |        :.|::.:.:|..|   ||..|
 Worm   919 YLHYLSEENLNGKTRMQLQFEDI----------C--------DCKHQPRCLIESD---VITLP-- 960

  Fly  1237 MRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPRKCPRYW 1301
                          ||..|:.|::..  ..|...|.||:..:|.|.|:|::::.....||.|...
 Worm   961 --------------GYHRSDEFMVGS--WGNECEDLWRLTWQQKVQTIVILNQRDSFWRKLPSCI 1009

  Fly  1302 ADDEVQYDH----ILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVDGEVPEVCR 1362
            .|.|:|..|    :|::....:.|.    |...|:...:|     |.|    |    .|:..|.:
 Worm  1010 YDGEIQLQHGDNFVLLQKDDQQLCV----RIVNVSRADLD-----TDF----W----REIENVQK 1057

  Fly  1363 GIIELVDQAY----NHYKNNKNSGCRSPLTVHCS-LGTDRSSIFVAMC---ILVQHLRLEKCVDI 1419
            ..|...|...    :.|..:..|...|..|:..| |..|.:::..::|   .|...|....|||:
 Worm  1058 QRITYHDAPLLILAHKYPPSVPSPTDSTSTLSLSILFNDDTALAFSICAATTLACQLETTGCVDV 1122

  Fly  1420 CATTRKLRSQRTGLINSYAQYEFLH 1444
            ..........:.|:..|..:.|.::
 Worm  1123 VQVLSSYTEIQCGIFASKQEIEIIY 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	Ig_3	35..114	CDD:464046
		Ig_3	134..216	CDD:464046	18/79 (23%)
		fn3	237..321	CDD:394996	22/91 (24%)
		FN3	<300..>524	CDD:442628	61/263 (23%)
		PTPc	892..1155	CDD:214550	94/267 (35%)
		PTPc	1186..1449	CDD:214550	56/271 (21%)
ptrg-1	NP_001255470.1	FN3	40..490	CDD:442628	116/538 (22%)
		FN3	140..232	CDD:238020	24/101 (24%)
		PTPc	642..900	CDD:214550	93/265 (35%)
		PTP_DSP_cys	959..1148	CDD:475123	48/224 (21%)