DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp69D and Y54F10BM.3

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	NP_001368044.1	Gene:	Y54F10BM.3 / 175350	WormBaseID:	WBGene00021858	Length:	622	Species:	Caenorhabditis elegans

Alignment Length:	385	Identity:	81/385 - (21%)
Similarity:	138/385 - (35%)	Gaps:	98/385 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   896 EYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVI--GYKE 958
            |:| :|...:..:..|..|    |::  |.::|:|.|...      :..|.:|:|:.|.  |.:.
Worm   264 EFE-IPIELTAMSAGNPKL----CRD--PKVQAWDSTSYL------VDDTHFIHASTVTAPGKEY 315

  Fly   959 RKKFICAQGPME-------STIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQF 1016
            ..|.|..|.|.:       .|.:.||||:|:.....:||...:.|....||.:|:|::...|:.:
Worm   316 IGKAIICQAPFDDKEKGHPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENY 380

  Fly  1017 GDILVKFAQ--ERKTGDYIERTLNVSKNKANVGEEEDR-RQITQYHYLTWKDFMAPEHPHGIIKF 1078
            |...|:..:  |...|..:.|.:.::.......:::.. |.||.:.:|.||:....|....:..|
Worm   381 GFAEVQLLEKHEMLNGHLLTRKIELTSGTWKHSDDDPPIRTITHFQFLKWKEGEGLEGEMSMDAF 445

  Fly  1079 IRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSL 1143
             ..:|........||:||.|.|.||....|..:.:.|.:..:...:......|.|.:|...:|:.
Worm   446 -NYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNG 509

  Fly  1144 KQYIFLYRALLDTGTFGNTDICIDTMASAIESLKRKPNEGKCKLEVEFEKLLATADEISKSCSVG 1208
            ||..::..                   .|.|.|.:|......|.|:|
Worm   510 KQLFWVQN-------------------MAFELLIKKLKMHHLKFEME------------------ 537

  Fly  1209 ENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENT 1268
              |:.|                                 |::.|.|.||...|:|.|..|
Worm   538 --EQWN---------------------------------FLKNYSNKETDKAARDTLAIT 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653
		Ig	150..221	CDD:143165
		fn3	237..321	CDD:278470
		FN3	339..432	CDD:238020
		FN3	439..535	CDD:238020
		PTPc	892..1155	CDD:214550	63/270 (23%)
		PTPc	920..1155	CDD:238006	57/246 (23%)
		PHA02694	<1121..1206	CDD:177476	13/84 (15%)
		PTPc	1186..1449	CDD:214550	14/83 (17%)
		PTPc	1216..1449	CDD:238006	9/53 (17%)
Y54F10BM.3	NP_001368044.1	Y_phosphatase	278..515	CDD:395053	60/249 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910