DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp69D and Ptpru

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_017448609.1	Gene:	Ptpru / 116680	RGDID:	620782	Length:	1452	Species:	Rattus norvegicus

Alignment Length:	1534	Identity:	355/1534 - (23%)
Similarity:	589/1534 - (38%)	Gaps:	320/1534 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 QTINKNHTRYKIRTEPLKSNDDGSENNDSQDFIKYKNVLALLDVNIKDSGN------YTCTAQTG 117
            ||:::|.|.....:..|.|.|..|...              |.|.::.:|.      :..|...|
  Rat    90 QTLSENDTHCVQFSYFLFSRDGHSPGT--------------LGVYVRVNGGPLGSAVWNMTGSHG 140

  Fly   118 -QNHSTEFQVRPYLPS--KVLQS---TPDRIKRKIKQDVMLY---CL----------IEMYPQNE 163
             |.|..|..|..:.|:  :||..   :||........|::|:   |.          :|:   |.
  Rat   141 RQWHQAELAVSTFWPNEYQVLFEALISPDHKGYIGLDDILLFSHPCAKAPHFSRLGDVEV---NA 202

  Fly   164 TTNRNLKWLKDGSQFE----FLDTFSSI-----SKLNDTHLNF--TLEFTEVYKKENGTYKCTVF 217
            ..|.:.:.:..|...|    ||...|.:     ...:.:|..|  |.....|.:.|...|:|...
  Rat   203 GQNASFQCMAAGRAAEAERFFLQRQSGVLVPAAGVRHISHRRFLATFPLASVGRSEQDLYRCVSQ 267

  Fly   218 DDTGLEITSKEITLFVMEVPQVSIDFAKAVGANKIYL------NWTVNDGNDPIQKFFITLQEAG 276
            ...|..:::  ....:::.|...|...:.:.|...||      |..:.||  ||.:..|..:.|.
  Rat   268 APRGAGVSN--FAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDG--PIVRKEIEYRMAR 328

  Fly   277 TPTFTYHKDFINGSHTSYILDHFKPNTTYFLRIV----GKNSIGN-----------GQPTQYPQG 326
            .|....|...:.    :|.|.|..|:|.|.:.::    |....|.           .:||:.|:|
  Rat   329 GPWAEVHAVNLQ----TYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLLSRTKCAEPTRAPKG 389

  Fly   327 ITTLSYDPIFIPKVETTGSTASTITIGWNPPPPDL-------IDYIQYYELIVSESGEVPKVIEE 384
               |::..|          .|..:|:.|.|...::       :....:|.|    .|...:.|.|
  Rat   390 ---LAFAEI----------QARQLTLQWEPLGYNVTRCHTYAVSLCYHYTL----GGSHNQTIRE 437

  Fly   385 AIYQQNSRN-------LPYMFDKLK-TATDYEFRVRACSDLTKTCGPWSENVNGTTMDGVATKPT 441
            .:..:...:       ||:....:: ..|:.|.|........:|    .|:|.|    |:|.:
  Rat   438 CVKMERGASRYTIKNLLPFRNVHVRLILTNPEGRKEGKEVTFQT----DEDVPG----GIAAE-- 492

  Fly   442 NLSIQCHHDNVTRGNSIAINWDVPKTPNGKVVSYLIHLLGNPMSTVDREMWGPKIRRIDEPHHKT 506
            :|:.....|      .|.:.|:.|:.|||.:..|.|.......|.....:.||: |.|.:..::|
  Rat   493 SLTFTPLED------MIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR-RTISKLRNET 550

  Fly   507 --LYESVSPNTNYTVTVSAITRHKKNGEPATGSCLMPVSTPDAIGRTMWSKVNLDSKYVLKLYLP 569
              ::.::.|.|.|..:|.|.| .|..|:.|.......:|.|......|.|.:. :|:..:.:.|.
  Rat   551 YHVFSNLQPGTTYLFSVRART-SKGFGQAALTEITTNISAPSFDYADMPSPLG-ESENTITVLLR 613

  Fly   570 KISERNGPICCYRLYLVRINNDNKELPDPEKLNIAT-YQEVHSDNVTRSSAYIAEMISSKYFRPE 633
            ....|..||..|::.:        |...|.:|.... .|:..|..:|..:|....::  .||..|
  Rat   614 PAQGRGAPISVYQVVV--------EEERPRRLRREPGGQDCFSVPLTFETALARGLV--HYFGAE 668

  Fly   634 IFLGDEKRFSENNDIIRDNDEICRKCLEGTPFL-----------------RKPEIIHIPPQGSLS 681
            :                    .....||..||.                 ||..:|:......|
  Rat   669 L--------------------AASSLLEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHL- 712

  Fly   682 NSDSELPILSEKDNLIKGANLTEHALKILESKL---RDKRNAVTSDENPILSAVNPNVPLHDSSR 743
                            ||           |::|   |..|.|...:...         ||..|.|
  Rat   713 ----------------KG-----------ETRLNCIRIARKAACKESKR---------PLEVSQR 741

  Fly   744 D--------VFDGEIDINSNYTGFLEIIV---RDRNNALMAYSKYFDIITPATEAEPIQSLNNMD 797
            .        :..|.:.:.....|.:.||:   |||    .|||.|   ..|...|:...:.....
  Rat   742 SEEMGLILGICAGGLAVLILLLGAIIIIIRKGRDR----YAYSYY---PKPVNMAKATVNYRQEK 799

  Fly   798 YYLSIGVKAGAVLLGVILVFIVLWVFHHKKTKNELQGEDTLTLRDSLSRALFGRRNHNHSHFITS 862
            .::...|...               |..:.|   ||.::.|.| ..:....:..|....|..:|.
  Rat   800 THMMTAVDRS---------------FTDQST---LQEDERLGL-SFMDAPGYSPRGDQRSSGVTE 845

  Fly   863 GNHK---------GFDAGPIHRLDLENAYK--------NRHKDTD-YGFLREYEMLPNRFSDRTT 909
            .:..         |....|.|...|..|.:        |:.|..: |||.:|||.....: |.|.
  Rat   846 ASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGW-DATK 909

  Fly   910 KNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFV------IGYKERKKFICAQGP 968
            |...||    ..|...:.|||:.||||..:.|....|||:||::      .||.....||..|||
  Rat   910 KKDKLK----SGRQEPVSAYDRHRVKLHPMLGDPDADYISANYIDIRINRQGYHRSNHFIATQGP 970

  Fly   969 MESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYI 1033
            ....|.|||||:|::....:||::.|.|..:.||::||||   |:..:|||.:...:.....:|:
  Rat   971 KPEMIYDFWRMVWQEQCVSVVMISKLVEVGRVKCSRYWPE---DSDMYGDIKITLVKTETLAEYV 1032

  Fly  1034 ERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCS 1098
            .||..:.:...:.     |.::.|:|:..|.:...|.|..|::.|||::.:......||:::|||
  Rat  1033 VRTFALERRGYSA-----RHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPVVIHCS 1092

  Fly  1099 AGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTD 1163
            ||.||||..:.||.::...|.|..|.|||.|..|..:|..::|:.:||||::.|:|:....|.|.
  Rat  1093 AGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETT 1157

  Fly  1164 ICIDTM-ASAIESLKRKPNEGKCKLEVEFEKLLATADEIS-KSCSVGENEENNMKNRSQEIIPYD 1226
            |.::.. |:..|.::..|.....:|..||:.|.:....:. :.||:.....|..||||.:::|.|
  Rat  1158 IPVNEFKATYREMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPD 1222

  Fly  1227 RNRVILTPLPMRENS-----TYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVM 1286
            |      .||...:|     .||||:..:.|..|..||:...||::|..||||::.:...|::||
  Rat  1223 R------CLPFLISSDGDPNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVM 1281

  Fly  1287 ISEI--GDGPRKCPRYWAD-DEVQYDHILVKYVHSESCPYYTRREFYVTNCK--IDDTLKVTQFQ 1346
            ::::  .:....|.:||.: ...||..:.|::|...:......|.|.|.|..  .:..|.|..||
  Rat  1282 LNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFVSGTANEDLVSRVFRVQNSSRLQEGHLLVRHFQ 1346

  Fly  1347 YNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHL 1411
            :..| :...:.|:..:..:.|:.:. :.::.....|   ...|||..|..||..|.|...:::.:
  Rat  1347 FLRW-SAYRDTPDSRKAFLHLLAEV-DKWQAESGDG---RTVVHCLNGGGRSGTFCACATVLEMI 1406

  Fly  1412 RLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY 1450
            |....||:....:.||:.:..::.:..||.|.:...:.|
  Rat  1407 RCHSLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY 1445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653	21/117 (18%)
		Ig	150..221	CDD:143165	17/94 (18%)
		fn3	237..321	CDD:278470	22/104 (21%)
		FN3	339..432	CDD:238020	18/107 (17%)
		FN3	439..535	CDD:238020	24/97 (25%)
		PTPc	892..1155	CDD:214550	93/268 (35%)
		PTPc	920..1155	CDD:238006	83/240 (35%)
		PHA02694	<1121..1206	CDD:177476	24/86 (28%)
		PTPc	1186..1449	CDD:214550	70/273 (26%)
		PTPc	1216..1449	CDD:238006	63/242 (26%)
Ptpru	XP_017448609.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810