Protein Alignment Ptp69D and PTPRT

DIOPT Version :10

• Sequence 1: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Sequence 2: NP_573400.3
• Gene: PTPRT / 11122
• HGNCID: 9682
• Length: 1460
• Species: Homo sapiens
• Alignment Length: 1540
• Identity: 378/1540 - (24%)
• Similarity: 631/1540 - (40%)
• Gaps: 336/1540 - (21%)

  Fly    26 VQGSVKQEWAEIGKNVSLECASENEAVAWKLGNQTI-----NKNHTRY------KIRTEPLKSND 79
            |.|.|.:.|.:....:|         ..|....|.|     .|.|..|      ::...|.:.
Human   138 VSGVVTEGWVKAELAIS---------TFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRK-- 191

  Fly    80 DGSENNDSQDFIKYKNVLALLDVNIKDSGNYTCTAQTGQNHSTEFQVRPYLPSKVLQSTPDRIKR 144
                   :..|::.:||    :||:..:..:.|.|  |...|..                |::
Human   192 -------APHFLRLQNV----EVNVGQNATFQCIA--GGKWSQH----------------DKL-- 225

  Fly   145 KIKQDVMLYCLIEMYPQNETTNRNLKWLKDGSQFEFLDTFSSISK-LNDTHLNFTLEFTEVYKKE 208
                                      ||:   |:...||...::: :|....:.|:...:..::.
Human   226 --------------------------WLQ---QWNGRDTALMVTRVVNHRRFSATVSVADTAQRS 261

  Fly   209 NGTYKCTVFDDTGLEITSKEITLFVMEVP-QVSIDFAKAVGANKIYLNWTVND--GNDPIQKFFI 270
            ...|:|.:..|.|..: |....|.|.|.| .::.....||||..:::....|.  |:.||   .:
Human   262 VSKYRCVIRSDGGSGV-SNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPI---IL 322

  Fly   271 TLQEAGTPTFTYHKDFINGSHTSYILDHFKPNTTYFLRIV----GKNSIGNGQPTQYPQGITTLS 331
            ...|..|.|.|:.:..|..| .:|.|.|..|:..|.:|::    |:...|   |...|....|..
Human   323 KEVEYRTTTGTWAETHIVDS-PNYKLWHLDPDVEYEIRVLLTRPGEGGTG---PPGPPLTTRTKC 383

  Fly   332 YDPIFIPK-VETTGSTASTITIGWNPPPPDLIDY-----------IQYYELIVSESGEVPKVIEE 384
            .||:..|: ||.....|..:|:.|.|     ..|           :||..:...:..|..:||:.
Human   384 ADPVHGPQNVEIVDIRARQLTLQWEP-----FGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQT 443

  Fly   385 AIYQQNSRNLPYMFDKLK-TATDYEFRVRACSDLTKTCGPWSENVNGTT-MDGVATKPTNLSIQC 447
            :.:.......|:|..:|: ..::.|.|:.:...:.:|    .|:|.|.. ::.:...|..
Human   444 SSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT----EEDVPGAVPLESIQGGPFE----- 499

  Fly   448 HHDNVTRGNSIAINWDVPKTPNGKVVSYLIH--LLGNPMSTVDREMWGPKIRRI-DEPHHKTLYE 509
                    ..|.|.|..|...||.:..|.|:  .:|:...:.|......|:.:: :|.||  |:.
Human   500 --------EKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHH--LFV 554

  Fly   510 SVSPNTNYTVTVSAITRHKKNGEPATGSCLMPVSTPDAIGRTMWSKVNLDSKYVLKLYLPKISER 574
            .:.|.|.|:.|:.|.|. |..|.|.|......:|.|........:.:| ::...:.:.|.....|
Human   555 GLYPGTTYSFTIKASTA-KGFGPPVTTRIATKISAPSMPEYDTDTPLN-ETDTTITVMLKPAQSR 617

  Fly   575 NGPICCYRLYLVRINNDNKELPDPEKLNIATYQEVHSDNVTRSSAYIAEMISSKYFRPEI----- 634
            ..|:..|:|.:       ||....:....|...|..|..|:..:|  :.:.|..||..|:
Human   618 GAPVSVYQLVV-------KEERLQKSRRAADIIECFSVPVSYRNA--SSLDSLHYFAAELKPANL 673

  Fly   635 ------FLGDEKRFSENNDIIRDNDEICRKCLEGTPFLRKPEIIHIPPQGSLSNSDSELPILSEK 693
                  .:||.|.::...:                           ||...|.:.......||:.
Human   674 PVTQPFTVGDNKTYNGYWN---------------------------PPLSPLKSYSIYFQALSKA 711

  Fly   694 DNLIKGANLTEHALKILESKLRDKRNAVTSDENPILSA-VNPNVPLHDSSRDVFDGEIDINSNYT 757
            :.               |:|:...|.|..:   |:.|| |.|..||    ..:..|....|||
Human   712 NG---------------ETKINCVRLATKA---PMGSAQVTPGTPL----CLLTTGASTQNSN-- 752

  Fly   758 GFLEIIVRDRNNALMAYSKYFDIITPATEAEPIQSLNNMDYYLSIGVKAGAVLLGVILVFIVLWV 822
                                        ..||.:.::|.  ....||.||.::..:||:.::|.:
Human   753 ----------------------------TVEPEKQVDNT--VKMAGVIAGLLMFIIILLGVMLTI 787

  Fly   823 FH----------------HKKTKNELQGE-------DTLTLRDSLSRALFGRRNHNHSHFITSGN 864
            ..                .|:|::..|.|       |..|.:.|.||        |...|.:|..
Human   788 KRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASR--------NDEGFSSSSQ 844

  Fly   865 H-KGFDAG---------------PIHRLD-LENAYKN-------------RH-----KDTDYGFL 894
            . .||..|               |....| :|.:|..             :|     :...|||.
Human   845 DVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFK 909

  Fly   895 REYEMLP-NRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKE 958
            .|||.|| .:.:...|...|  ||..||||.:|.:||.:||:|.|::|...:||||||::.||..
Human   910 EEYEALPEGQTASWDTAKED--ENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHR 972

  Fly   959 RKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKF 1023
            .:.:|..||||:.|:.|||||||:::...|||:|||.|..:.||.:|||:   ||:.:|||.|..
Human   973 PRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD---DTEVYGDIKVTL 1034

  Fly  1024 AQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSL 1088
            .:.....:|:.||..|.|.    |..| .|::..:|:.:|.|...|.:..|::.|:||:..:...
Human  1035 IETEPLAEYVIRTFTVQKK----GYHE-IRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPP 1094

  Fly  1089 QRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRAL 1153
            :.|||:||||||.||||..:|:|:::...|.|..|.|:|.|.:||.||..|||:.:||:|::.|:
Human  1095 EAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1159

  Fly  1154 LDTGTFGNTDICIDTMASAIESLKR-KPNEGKCKLEVEFEKL-LATADEISKSCSVGENEENNMK 1216
            |:....|||.|.:....|...::.| .|.....:::.||:.| :.|.....:.||:|....|:.|
Human  1160 LEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDK 1224

  Fly  1217 NRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSV 1281
            |||.:::|.||....|..:. .|:|.||||:.::.:.....|::.|.||.||:.||||::.:.:.
Human  1225 NRSMDVLPLDRCLPFLISVD-GESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNC 1288

  Fly  1282 TTLVMISEIGDGPRKCPRYWADDEVQ-YDHILVKYVHSESCPYYTRREFYVTN-CKIDDTLKVTQ 1344
            :::||::|: |..:.|.:||.:.... |..|.|::|.::.......|.|.:.| .:..|..::.|
Human  1289 SSVVMLNEM-DTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQ 1352

  Fly  1345 -FQYNGWPTVDGEVPEVCRGIIELV---DQAYNHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAMC 1405
             .||.|||.. .:.|...|.::::|   ::....|     .|......|||..|..||..|.|:|
Human  1353 HLQYIGWPAY-RDTPPSKRSLLKVVRRLEKWQEQY-----DGREGRTVVHCLNGGGRSGTFCAIC 1411

  Fly  1406 ILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY 1450
            .:.:.::.:..:|:....:.||:.::.::.:..||:|::...:.|
Human  1412 SVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY 1456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	Ig_3	35..114	CDD:464046	14/89 (16%)
		Ig_3	134..216	CDD:464046	10/82 (12%)
		fn3	237..321	CDD:394996	23/90 (26%)
		FN3	<300..>524	CDD:442628	52/244 (21%)
		PTPc	892..1155	CDD:214550	110/263 (42%)
		PTPc	1186..1449	CDD:214550	73/269 (27%)
PTPRT	NP_573400.3	MAM	29..189	CDD:214533	11/59 (19%)
		fn3	294..360	CDD:394996	19/69 (28%)
		FN3	390..480	CDD:238020	18/94 (19%)
		fn3	502..577	CDD:394996	23/77 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	809..858		14/56 (25%)
		R-PTPc-T-1	929..1165	CDD:350478	103/245 (42%)
		R-PTPc-T-2	1250..1455	CDD:350482	55/211 (26%)