Protein Alignment Ptp69D and PTPRU

DIOPT Version :9

• Sequence 1: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Sequence 2: XP_016855481.1
• Gene: PTPRU / 10076
• HGNCID: 9683
• Length: 1452
• Species: Homo sapiens
• Alignment Length: 1560
• Identity: 352/1560 - (22%)
• Similarity: 585/1560 - (37%)
• Gaps: 372/1560 - (23%)

  Fly    59 QTINKNHTRYKIRTEPLKSNDDGSENNDSQDFIKYKNVLALLDVNIKDSGN------YTCTAQTG 117
            |::::|.|.....:..|.|.|..|...              |.|.::.:|.      :..|...|
Human    90 QSLSENDTHCVQFSYFLYSRDGHSPGT--------------LGVYVRVNGGPLGSAVWNMTGSHG 140

  Fly   118 -QNHSTEFQVRPYLPS--KVLQS---TPDRIKRKIKQDVMLYCLIEMYP--------------QN 162
             |.|..|..|..:.|:  :||..   :|||.......|::|.    .||              .|
Human   141 RQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLL----SYPCAKAPHFSRLGDVEVN 201

  Fly   163 ETTNRNLKWLKDGSQFE-----------FLDTFSSISKLNDTHLNFTLEFTEVYKKENGTYKCTV 216
            ...|.:.:.:..|...|           .|...:.:..::......|.....|.:.|...|:|..
Human   202 AGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVS 266

  Fly   217 FDDTGLEITSKEITLFVMEVPQVSIDFAKAVGANKIYL------NWTVNDGNDPIQKFFITLQEA 275
            ....|..:::  ....:::.|...|...:.:.|...||      |..:.||  ||.:..|..:.|
Human   267 QAPRGAGVSN--FAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDG--PIVRKEIEYRMA 327

  Fly   276 GTPTFTYHKDFINGSHTSYILDHFKPNTTYFLRIV----GKNSIGNGQPTQYPQGITTLSYDPIF 336
            ..|....|.    .|..:|.|.|..|:|.|.:.::    |....|...|   |....|...:|:.
Human   328 RGPWAEVHA----VSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGP---PLISRTKCAEPMR 385

  Fly   337 IPK-VETTGSTASTITIGWNPPPPDL-------IDYIQYYELIVSESGEVPKVI--EEAIYQQNS 391
            .|| :......|..:|:.|.|...::       :....:|.|..|.:..:.:.:  |:.:.:...
Human   386 APKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI 450

  Fly   392 RN-LPYMFDKLK-TATDYEFRVRACSDLTKTCGPWSENV-NGTTMDGVATKPTNLSIQCHHDNVT 453
            :| |||....:: ..|:.|.|........:|    .|:| :|...:.:...|..
Human   451 KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQT----DEDVPSGIAAESLTFTPLE----------- 500

  Fly   454 RGNSIAINWDVPKTPNGKVVSYLIHLLGNPMSTVDREMWGPKIRRIDEPHHKT--LYESVSPNTN 516
              :.|.:.|:.|:.|||.:..|.|.......|.....:.||: |.|.:..::|  ::.::.|.|.
Human   501 --DMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR-RTISKLRNETYHVFSNLHPGTT 562

  Fly   517 YTVTVSAITRHKKNGEPATGSCLMPVSTPDAIGRTMWSKVNLDSKYVLKLYLPKISERNGPICCY 581
            |..:|.|.| .|..|:.|.......:|.|
Human   563 YLFSVRART-GKGFGQAALTEITTNISAP------------------------------------ 590

  Fly   582 RLYLVRINNDNKELPDPEKLNIATYQEVHSDNVTRSSAYIAEMISSKYFRPEIFLGDEKRFSENN 646
                   :.|..::|.|                                     ||:    |||.
Human   591 -------SFDYADMPSP-------------------------------------LGE----SENT 607

  Fly   647 DIIRDNDEICRKCLEGTPFLRKPEIIHIPPQGSLSNSDSELPILSEKDNLIKGANLTEHALKILE 711
            .               |..||       |.||                   :||.::.:.:.:.|
Human   608 I---------------TVLLR-------PAQG-------------------RGAPISVYQVIVEE 631

  Fly   712 SKLRD-KRNAVTSDENPI---LSAVNPNVPLH--------DSSRDVFDGEIDINSNYTGFLEIIV 764
            .:.|. :|.....|..|:   ..|......:|        .|..:.....:..|..|.||....:
Human   632 ERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPL 696

  Fly   765 RDRNNALMAYSKYF------------DIITPATEA------EPIQ-SLNNMDYYLSIGVKAGA-- 808
            ..|.    ||..||            :.|..|.:|      .|:: |..:.:..|.:|:.||.
Human   697 EPRK----AYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLA 757

  Fly   809 ---VLLGVILVFIVLWVFHH------------KKTKNELQGE------------DTLTLRDSLSR 846
               :|||.|:|.|.....|:            |.|.|..|.:            |..||::....
Human   758 VLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERL 822

  Fly   847 ALFGRRNHNHSHFITSGNHK-------------------GFDAGPIHRLDLENAYK--------N 884
            .|.....|.:|   |.|:.:                   |....|.|...|..|.:        |
Human   823 GLSFMDTHGYS---TRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHIN 884

  Fly   885 RHKDTD-YGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYI 948
            :.|..: |||.:|||.....: |.|.|...:|    .:|...:.|||:.||||..:.|....|||
Human   885 QMKTAEGYGFKQEYESFFEGW-DATKKKDKVK----GSRQEPMPAYDRHRVKLHPMLGDPNADYI 944

  Fly   949 NANFV------IGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWP 1007
            |||::      .||.....||..|||....:.|||||:|::|...|||:|.|.|..:.||::|||
Human   945 NANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP 1009

  Fly  1008 EKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHP 1072
            |   |:..:|||.:...:.....:|:.||..:.:...:.     |.::.|:|:..|.:...|.|.
Human  1010 E---DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSA-----RHEVRQFHFTAWPEHGVPYHA 1066

  Fly  1073 HGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRN 1137
            .|::.|||::.:......|||::|||||.||||..:.||.::...|.|..|.|||.|..|..:|.
Human  1067 TGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRV 1131

  Fly  1138 FLVQSLKQYIFLYRALLDTGTFGNTDICI-DTMASAIESLKRKPNEGKCKLEVEFEKLLATADEI 1201
            .::|:.:||||::.|:|:....|.|.|.: :..|:..|.::..|.....:|..||:.|.:....:
Human  1132 NMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPL 1196

  Fly  1202 S-KSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPM-----RENSTYINASFIEGYDNSETFII 1260
            . :.||:.....|..||||.:::|.||      .||.     .:::.||||:..:.|..|..||:
Human  1197 DVEECSIALLPRNRDKNRSMDVLPPDR------CLPFLISTDGDSNNYINAALTDSYTRSAAFIV 1255

  Fly  1261 AQDPLENTIGDFWRMISEQSVTTLVMISEI--GDGPRKCPRYWAD-DEVQYDHILVKYVHSESCP 1322
            ...||::|..||||::.:...|::||::::  .:....|.:||.: ...||..:.|:::...:..
Human  1256 TLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADE 1320

  Fly  1323 YYTRREFYVTNCK--IDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNSGCRS 1385
            ....|.|.|.|..  .:..|.|..||:..| :...:.|:..:..:.|:.:. :.::.....|
Human  1321 DLVARVFRVQNISRLQEGHLLVRHFQFLRW-SAYRDTPDSKKAFLHLLAEV-DKWQAESGDG--- 1380

  Fly  1386 PLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVDICATTRKLRSQRTGLINSYAQYEFLHRAIINY 1450
            ...|||..|..||..|.|...:::.:|....||:....:.||:.:..::.:..||.|.:...:.|
Human  1381 RTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY 1445

  Fly  1451  1450
            Human  1446  1445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653	18/118 (15%)
		Ig	150..221	CDD:143165	13/95 (14%)
		fn3	237..321	CDD:278470	23/93 (25%)
		FN3	339..432	CDD:238020	20/105 (19%)
		FN3	439..535	CDD:238020	23/97 (24%)
		PTPc	892..1155	CDD:214550	96/268 (36%)
		PTPc	920..1155	CDD:238006	87/240 (36%)
		PHA02694	<1121..1206	CDD:177476	24/86 (28%)
		PTPc	1186..1449	CDD:214550	68/273 (25%)
		PTPc	1216..1449	CDD:238006	61/242 (25%)
PTPRU	XP_016855481.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810