Protein Alignment Ptp69D and ptpre

DIOPT Version :10

• Sequence 1: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Sequence 2: XP_004912774.1
• Gene: ptpre / 100497631
• XenbaseID: XB-GENE-982136
• Length: 714
• Species: Xenopus tropicalis
• Alignment Length: 685
• Identity: 236/685 - (34%)
• Similarity: 367/685 - (53%)
• Gaps: 81/685 - (11%)

  Fly   807 GAVLLGVILVFIVLWVF------------HHKKTKN-----------ELQGEDTLTLRDSLSRAL 848
            |::|..|::..:|.:|.            |.|...|           |.|.:.|:.|..| |..:
 Frog    65 GSLLTSVLVPLLVCFVLILLAGYLLRSRKHRKADVNTSDKKMPNGILEEQEQQTVMLLSS-SPTV 128

  Fly   849 FGRRNHNHSHFITSGNHKGFDAGPIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSD 913
            :.:      :|            ||...:||..::.|..|....|..||..|.......|.:.::
 Frog   129 YKK------YF------------PIPVENLEEEFRIRSADDGKLFREEYNSLQPGSIHGTHEAAN 175

  Fly   914 LKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWR 978
            .:||..|||||:|..|||:||.|..::|...:|||||:::.|||||.|||.||||.:.|::||||
 Frog   176 KEENKEKNRYPNILPYDQSRVILIPVDGGPCSDYINASYIDGYKERNKFIAAQGPKQETVNDFWR 240

  Fly   979 MIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNK 1043
            |||||....|||||||:|..:.||.:|||::  ....:|:|.|.........||..|       |
 Frog   241 MIWEQKSATIVMLTNLKERKEDKCYQYWPDQ--GCWIYGNIRVAVEDVVVLVDYTIR-------K 296

  Fly  1044 ANVGEEED----RRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRT 1104
            ..:....|    .|.|||.|:.:|.||..|..|.|::||::::.||..:..|||:||||||||||
 Frog   297 FCIQPVHDGCKAPRLITQLHFTSWPDFGVPFTPIGMLKFLKKVKSVNPVHAGPIVVHCSAGVGRT 361

  Fly  1105 GTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTM 1169
            ||.:.:|::|..:.||..|::::.|..:|:||..:||:..||.|:|:|||:...:|:|::.:.::
 Frog   362 GTFIVIDAIIDMMNEEKKVNVFDFVSKIRNQRPQMVQTDMQYSFIYQALLEYYLYGDTELDVASL 426

  Fly  1170 ASAIESL-KRKPNEGKCKLEVEFEKLLATADEISK-SCSVGENEENNMKNRSQEIIPYDRNRVIL 1232
            ...:::| ...|:..|..||.||:||  |:..|.| :...|....|..|.|..:|||||.|||||
 Frog   427 EKHLQALYTPAPHFDKIGLEQEFKKL--TSVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVIL 489

  Fly  1233 TPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGDFWRMISEQSVTTLVMISEIGDGPR-K 1296
            :.....|.:.|||||||:||...:.||..|.||.:|:.|||||:.|....|:|:::|:.:..: |
 Frog   490 SMKRGEEYTDYINASFIDGYRQKDYFIATQGPLPHTVEDFWRMVWEWKSHTIVILTELQEREQEK 554

  Fly  1297 CPRYW-ADDEVQYDHILVKYVHSESCPYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVDGEVPEV 1360
            |.:|| ::..|.:..|.::..........:.|:|.||:.:...|..|.||.::|||.:.  :|..
 Frog   555 CCQYWPSEGTVTHGEINIEIKSDRLLDTISVRDFIVTSSQEKQTRLVRQFHFHGWPEIG--IPAE 617

  Fly  1361 CRGIIELV-------DQAYNHYKNNKNSGCRSPLTVHCSLGTDRSSIFVAMCILVQHLRLEKCVD 1418
            .:|:|:|:       .|..||           |:.||||.|..|:..|:|:..:::.::.|..:|
 Frog   618 GKGMIDLIAAVQKQQQQTGNH-----------PIVVHCSAGAGRTGTFIALSNILERVKAEGLLD 671

  Fly  1419 ICATTRKLRSQRTGLINSYAQYEFLHRAIINYSDL 1453
            :..|.:.||.||..::.:..||||.::.:.:|.|:
 Frog   672 VFQTIKSLRMQRPHMVQTLEQYEFCYKVVQDYIDI 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	Ig_3	35..114	CDD:464046
		Ig_3	134..216	CDD:464046
		fn3	237..321	CDD:394996
		FN3	<300..>524	CDD:442628
		PTPc	892..1155	CDD:214550	115/266 (43%)
		PTPc	1186..1449	CDD:214550	92/272 (34%)
ptpre	XP_004912774.1	R-PTPc-E-1	185..412	CDD:350468	105/235 (45%)
		R-PTPc-E-2	499..703	CDD:350470	68/216 (31%)