Protein Alignment Ptp69D and ptpn14

DIOPT Version :10

• Sequence 1: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Sequence 2: XP_031758936.1
• Gene: ptpn14 / 100379917
• XenbaseID: XB-GENE-985641
• Length: 1176
• Species: Xenopus tropicalis
• Alignment Length: 1346
• Identity: 277/1346 - (20%)
• Similarity: 471/1346 - (34%)
• Gaps: 384/1346 - (28%)

  Fly     7 RMSMLLNIILAYIFLCAICVQGSVKQEWAEIGKNVSLECASENEAVAWKL--------GNQTINK 63
            |.:...|::....|:..|.:..:.:.|:.....:..|||.   ||||.:|        |.|.:.|
 Frog     8 RRTKRYNVLSKNCFVVRIQLLDNSEVEYTRTVDSTGLECL---EAVAQRLELCEIHCFGLQYVGK 69

  Fly    64 NHTRYKIRTE-PLKSNDDGSENNDSQDFIKYKNVLALLDVNIKDSGNYTCTAQTGQNHSTEFQVR 127
            |:....:..| .||...|...|.    |:.:..::..:. |:    :|.....|...:..:.:..
 Frog    70 NNQMRWVELEKSLKKQLDKFANK----FLVFFGIMYYVP-NV----SYLKQPTTRTQYYLQLKKD 125

  Fly   128 PYLPSKVLQSTPD-------RIKRKIKQDVML--YCLIE---MYPQNETTNRNLKWLKDGS---- 176
            .| ..::..|...       .::.:||...:|  |..::   ::||        .|.||.:
 Frog   126 VY-EGRLCGSAEQYFRLAGLALRAEIKDFDLLGTYHFLKDYTLFPQ--------AWTKDEAMLEG 181

  Fly   177 --------------------------QFEFLDTFSSIS-KLNDTH---LNFTLEFTEVYKKEN-- 209
                                      :.|.:|.:...| .:.|.|   :|..:.|..::.:.|
 Frog   182 LCHKVALEYKALSGIPSAEAEILYLKEAEHMDGYGQESFHMKDNHGNDINLCISFMGIFIRNNCR 246

  Fly   210 ---GTYKCTVFDDTG----------LEITSKEITLFVMEVPQVSID-----------FA---KAV 247
               .||:   :.|.|          ||:..||      ||...|.|           ||   |..
 Frog   247 QATATYR---WSDIGNITHNKSAIVLELNRKE------EVVVFSTDDIENSKYITRLFAARHKFY 302

  Fly   248 GANKIYL-------------NWT---------------VNDGNDPIQKFFITLQEAGTPTFTYHK 284
            ..|||..             ||.               ::.|...|.:..|         |..::
 Frog   303 KDNKICTEQSSSPPAVRRQPNWNRSSMSRQQTILPPRHIHGGETYISEDNI---------FHMNE 358

  Fly   285 DFIN-GSHTSYILDHF-KPNTTYFLRIVGKNSIGNGQPTQYPQGITTLSYDPIFIPKVETTGSTA 347
            |..| .|.||  ||.: .||   |:    ..::.||..:. ...|.:|:....||    .....:
 Frog   359 DAFNYRSQTS--LDRYLDPN---FI----NGTLVNGSDSS-AHSINSLNRSQNFI----QASPMS 409

  Fly   348 STITIGWNPPPPDLI--DYIQYY--ELIVSESGEVPKVIEEAIYQQNSRNLP-----YMFDKLKT 403
            |:::|..|    |::  |||..|  ..|::.|.......|..:.|.|...:|     .....|..
 Frog   410 SSLSIQSN----DIMRADYIPSYRHSAIIAPSYRPTPDYETVMRQMNRGIIPMDCQSQSLRNLNI 470

  Fly   404 ATDYEFRVRACSDLTKTCGPWSENVNGTTMDGVATKPTNLSIQCHHDNV------TRGNSIAINW 462
            ...:.:|.|             ||:       |.::|   .||..|..|      |...::.||
 Frog   471 GNTHAYRHR-------------ENL-------VYSQP---EIQERHAYVPPYVPQTAYTNVLIN- 511

  Fly   463 DVPKTPNGKVVSYLIHLLGNPMSTVDREMWGPK------------IRRIDEPHHKTLYESVSPNT 515
            .:.:....||.|.....:.:.:||.:.....|:            :.|...|:..|...|.:|:
 Frog   512 PIEQINPTKVTSNQAKAISHTVSTPELANVPPQAVQSAALMLKNFLSRPPPPYPPTRPASSTPD- 575

  Fly   516 NYTVTVSAITRHKKNGEPATGSCLMPVSTPDAIGRTMWSKVNL---DSKYVLKLYLPKISERNGP 577
                    :..|::  :..:|      |:||.:.|.:...|..   ||..|:...|.::||
 Frog   576 --------LASHRQ--KRVSG------SSPDLVTRKVQQSVKTFQEDSAPVVHQSLQEVSE---- 620

  Fly   578 ICCYRLYLVRINNDNKELPDPEKLNIATYQEVHSDNVTRSSAYIAEMISSKYFRPEIFLGDEKRF 642
                .|.:|:        |.|      :..:.||..|..:.....|.::.|
 Frog   621 ----PLMMVK--------PHP------SVNKCHSFEVITNMVRGMEAMALK-------------- 653

  Fly   643 SENNDIIRDNDEICRKCLEGTPFLRKPEIIHIPPQGSLSNSD--SELPILSEKDNLIKGANLTEH 705
            :.|..:.|.|.            ||:    .:|.:.|:..:.  .:||:...|      .|:::.
 Frog   654 TMNAHLPRRNT------------LRE----QVPTEESMQKAHEVQQLPMYHHK------KNISDA 696

  Fly   706 ALKILESKLRDKRNAVTSDENPILSAVNPNVPLHDSSRDVFDGEIDI---------NSNYTGFLE 761
            .:.||.|:..:       :|.|..| |:|..||...:   :..::..         ...|.|..:
 Frog   697 TMLILSSESEE-------EEEPHKS-VSPTSPLQGMA---YSAQLQAALARIPKKPPPEYPGPRK 750

  Fly   762 IIVRDRNNALMAYSKYFDIITPATEA---EPIQ----------SLNNMDYYLSIGVKAGAVLLGV 813
            .|   .|.||...|.....:....:|   .|.|          ::|..    |:|.......|..
 Frog   751 SI---SNGALRHESSNISSVIARAKAMSQRPCQAACISKTEPAAMNGS----SLGPSISEPDLTC 808

  Fly   814 ILVFIVLWVFHHKKTKNELQGEDTLTLRDSLSRALFGRRNHNHSHFITSGNHKGFDAGPIHRLDL 878
            :...|.......:........||.:..|:.:.|.|     ............:......::.|.:
 Frog   809 VKERIKKEPVKERPVSEMFSIEDVIVEREIMMRNL-----EKQEMAALEAQKRPLMMAALNGLSV 868

  Fly   879 ENAYKNRHKDTDYGFLR-------------------EYEMLPNRFSDRTTKNSDLKENACKNRYP 924
            ....:...:..|...::                   |||.:|.|..:.....:.|.||..:||..
 Frog   869 SRIARPEDRQDDTALIQMDERCKTLRWRLEEGMVFTEYEQIPKRKPEGVFTTAVLPENLERNRIC 933

  Fly   925 DIKAYDQTRVKLAVINGLQTTDYINANFV---IGYKERKKFICAQGPMESTIDDFWRMIWEQHLE 986
            :...|::.||:| |......|.||||:.:   :..|: ..:|..|||:..|..|||:|:|||.:.
 Frog   934 EDIPYEENRVEL-VPTKENPTGYINASHIKVTVSGKD-WHYIATQGPLPHTFHDFWQMVWEQGVN 996

  Fly   987 IIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKF--AQERKTGDYIERTLNVSKNKANVGEE 1049
            :|.|:...||..:||..:|||:  ..||...:...||  ....:|......|..:.......|:|
 Frog   997 VIAMVNADEEEGRAKSHRYWPK--LGTKHNSETYGKFKVTTNFRTDSGCYATTGLKVKHLLTGQE 1059

  Fly  1050 EDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSV------YSLQRGPILVHCSAGVGRTGTLV 1108
               |.:....:..|.|...|:...|.:.::.:|.||      .||...|::|||||||||||.:|
 Frog  1060 ---RTVWHLQFTDWPDHGCPDEMQGFLSYLEEIRSVRRHANPSSLCNPPVVVHCSAGVGRTGVVV 1121

  Fly  1109 ALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL 1154
            ..:.:|:.||..:::.|...:..||.||.|::|::.||.|:|:.|:
 Frog  1122 LTELMIRCLENNENIEIPAMLRHLREQRMFMIQTIAQYTFVYQVLI 1167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	Ig_3	35..114	CDD:464046	20/87 (23%)
		Ig_3	134..216	CDD:464046	20/132 (15%)
		fn3	237..321	CDD:394996	26/127 (20%)
		FN3	<300..>524	CDD:442628	48/250 (19%)
		PTPc	892..1155	CDD:214550	88/293 (30%)
		PTPc	1186..1449	CDD:214550
ptpn14	XP_031758936.1	FERM_F1_PTPN14_like	18..102	CDD:340619	21/90 (23%)
		B41	22..220	CDD:214604	36/218 (17%)
		FERM_C_PTPN14_PTPN21	215..305	CDD:270009	21/98 (21%)
		PTPc-N14	889..1171	CDD:350447	88/286 (31%)