DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp69D and ptpn23a

DIOPT Version :9

Sequence 1:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster
Sequence 2:	XP_005158252.1	Gene:	ptpn23a / 100007322	ZFINID:	ZDB-GENE-100921-24	Length:	2003	Species:	Danio rerio

Alignment Length:	362	Identity:	97/362 - (26%)
Similarity:	164/362 - (45%)	Gaps:	52/362 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   888 DTDYGFLREYEMLPNRFSDRTTKNSDLKENAC---KNRYPDIKAYDQTRVKLAVINGLQTTDYIN 949
            |..:..|:|.:       ::.|:...:....|   |||:.|:..||..||.|.  :|  ..||||
Zfish  1521 DAQWKELQEQQ-------EKDTRQLSIAIARCYTMKNRHQDVMPYDCNRVVLH--SG--KDDYIN 1574

  Fly   950 ANF---VIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVF 1011
            |:|   :..|..|  .|..|.|:..|..|||.|::||.:.:||||.:.:|..|.|..:|:|.:..
Zfish  1575 ASFTEDLSPYCPR--LIATQAPLTGTAADFWLMVYEQKVSVIVMLVSEQELEKQKVLRYFPSERG 1637

  Fly  1012 DTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGII 1076
            .....|.|.:....::.|..:|||.:.:...     ::..||.:....:.:|.:...||....:|
Zfish  1638 QQLAQGPITLTLTTQKSTPTHIERMIGLQYR-----DQSLRRTVVHLQFTSWPELGLPESKSNLI 1697

  Fly  1077 KFIRQINSVYSLQR---GPILVHCSAGVGRTGTLVALDSLIQQLEEEDSV-SIYNTVCDLRHQRN 1137
            :||::::..|.|||   .|::||||:||||||....|.:.:|::|..:.: .:...|..:|.||.
Zfish  1698 RFIQEVHGHYLLQRPLHTPVVVHCSSGVGRTGAFCLLYAALQEIEAGNGIPDLIQLVRKMRQQRK 1762

  Fly  1138 FLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKRKPNEGKCKL-------------EV 1189
            .::|......|.|.|:|.     :|:..:...........|.||....|.             ::
Zfish  1763 NMLQEKLHLKFCYEAVLK-----HTEQVLQRHGIITSPCTRTPNNITLKSYSRQESQDIVLGGDM 1822

  Fly  1190 EFEKLLATADEIS-KSCSVGENEENNMKNRSQEIIPY 1225
            ....:.||..::| :..||...:|     .||:.:|:
Zfish  1823 PISSIQATVAKLSIRPPSVDHEQE-----PSQDQMPF 1854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653
		Ig	150..221	CDD:143165
		fn3	237..321	CDD:278470
		FN3	339..432	CDD:238020
		FN3	439..535	CDD:238020
		PTPc	892..1155	CDD:214550	81/272 (30%)
		PTPc	920..1155	CDD:238006	77/241 (32%)
		PHA02694	<1121..1206	CDD:177476	17/99 (17%)
		PTPc	1186..1449	CDD:214550	10/54 (19%)
		PTPc	1216..1449	CDD:238006	3/10 (30%)
ptpn23a	XP_005158252.1	BRO1_HD-PTP_like	2..357	CDD:185762
		V_HD-PTP_like	362..698	CDD:185747
		ALIX_LYPXL_bnd	416..701	CDD:290660
		Y_phosphatase	1548..1780	CDD:278528	77/242 (32%)
		PTPc	1549..1779	CDD:238006	77/240 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910