Protein Alignment mirr and IRX3

DIOPT Version :9

• Sequence 1: NP_001261778.1
• Gene: mirr / 39441
• FlyBaseID: FBgn0014343
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: XP_005256196.1
• Gene: IRX3 / 79191
• HGNCID: 14360
• Length: 529
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 184/594 - (30%)
• Similarity: 229/594 - (38%)
• Gaps: 226/594 - (38%)

  Fly    72 PGARSTSPCGPSAGLPALSLVGAPPPGPHSSAPGGAPAPGAG----NPPNRCCDTGRTIYTDPVS 132
            |||...|  |.|||                 |.||.   |||    |......:...::|..|
Human    20 PGAAGGS--GGSAG-----------------ARGGL---GAGASELNASGSLSNVLSSVYGAP-- 60

  Fly   133 GQTICSCQYDMLNYQRLAAAGGVPLGVYPEGMSAYLSGIAADQPPFYANPAGIDLKEN------L 191
                         |...|||...      :|..|:|. .||:.|.|....|..:||::      .
Human    61 -------------YAAAAAAAAA------QGYGAFLP-YAAELPIFPQLGAQYELKDSPGVQHPA 105

  Fly   192 VAGASPWPYPSMYHPYDAAFAGYPFNSYGMDLNGARRKNATRETTSTLKAWLNEHKKNPYPTKGE 256
            .|.|.|.|:|:.| ||.....|.|          :|.||||||:|||||||||||:|||||||||
Human   106 AAAAFPHPHPAFY-PYGQYQFGDP----------SRPKNATRESTSTLKAWLNEHRKNPYPTKGE 159

  Fly   257 KIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPRNRVDDDDANIDDDDDKNTEDNDLLDAK- 320
            ||||||||||||||||||||||||||||||||||.||:|.|::......:.::..|:.|..|.|
Human   160 KIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKR 224

  Fly   321 ---------------DSGVGSTDDKD----------------------RSGRLGDMMTDRPGESN 348
                           ..|.|..||.:                      .:.|.||:......:|.
Human   225 ELELEEEELGGEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSK 289

  Fly   349 NSEWSESRPGSPNGSPDLYDRP------GSMPPGAHPLFHPAALHHHFRPPAGSPP---DIAAYH 404
            ||:..:|..|       |.|||      ...||       |.|:   ..|...|||   |..|
Human   290 NSDSEDSSEG-------LEDRPLPVLSLAPAPP-------PVAV---ASPSLPSPPVSLDPCA-- 335

  Fly   405 HHQQQLLQQHQQAQQNSLQTAVGGTAKPRIWSLADMASKDSKDSSSGAKDNHPELPPAHPGFYGH 469
                     ...|..::||       ||:|||||:.|:         :.|| |...|  ||..|.
Human   336 ---------PAPAPASALQ-------KPKIWSLAETAT---------SPDN-PRRSP--PGAGGS 372

  Fly   470 PGQQPSPGKILSPLAARIPNYSPYVRPDLYRGFYGPAAAHLGAPTQEFLEHQRTFGASLAAH--- 531
            |     ||..::|.|.::                .|||                  |:.|||
Human   373 P-----PGAAVAPSALQL----------------SPAA------------------AAAAAHRLV 398

  Fly   532 NGPLGMNPLLWKAAVSGAANGHHFAPLSLTTSGGSSGGQQVAPPPVASPSASSSSSSMGCDVVHI 596
            :.|||..|........|...|....||||..|         |||                .::.:
Human   399 SAPLGKFPAWTNRPFPGPPPGPRLHPLSLLGS---------APP----------------HLLGL 438

  Fly   597 PTSSGQSAA 605
            |.::|..||
Human   439 PGAAGHPAA 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mirr	NP_001261778.1	Homeobox_KN	242..281	CDD:283551	37/38 (97%)
IRX3	XP_005256196.1	Homeobox_KN	145..184	CDD:283551	37/38 (97%)
		IRO	344..359	CDD:214716	10/30 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	0.375	Domainoid score	I8071
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5654
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	7.000