Protein Alignment mirr and IRX6

DIOPT Version :10

• Sequence 1: NP_001261778.1
• Gene: mirr / 39441
• FlyBaseID: FBgn0014343
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_077311.2
• Gene: IRX6 / 79190
• HGNCID: 14675
• Length: 446
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 158/471 - (33%)
• Similarity: 208/471 - (44%)
• Gaps: 109/471 - (23%)

  Fly    99 PHSSAP--GGAPAPGAGNPPNRCCDTGRTIYTDPVSGQT----ICSCQYDMLNYQRLAAAG---- 153
            ||...|  |.:....:.:....||::.:...:|..||.|    :|...||    .||..:.
Human     4 PHFGHPYRGASQFLASASSSTTCCESTQRSVSDVASGSTPAPALCCAPYD----SRLLGSARPEL 64

  Fly   154 GVPLGVYPEGMSAYLSGIAADQPPFY-------------ANPAGIDLKENLVAGASPWPYPSMYH 205
            |..||:|.   :.|.:..||...|.|             .||. .:.||...:..|....|..|:
Human    65 GAALGIYG---APYAAAAAAQSYPGYLPYSPEPPSLYGALNPQ-YEFKEAAGSFTSSLAQPGAYY 125

  Fly   206 PYDAAFAGYPFNSYG-MDLNGA-RRKNATRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTL 268
            ||:.....|.:..|| ::|:|| ||||||||||||||||||||:|||||||||||||||||||||
Human   126 PYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTL 190

  Fly   269 TQVSTWFANARRRLKKENKMTWEPRNRVDDD----------------------------DANIDD 305
            ||||||||||||||||||||||.|:|:..::                            ...:.|
Human   191 TQVSTWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGCLTADTKEVTASQEARGLRLSD 255

  Fly   306 DDDKNTEDNDLLDAKDSGVGSTDDKDRSGRLGDMMTD-RPGESNNSEWSESRPGSPNGSPDLYDR 369
            .:|...|:.:..:|:|..|.:|        .||.:|: |.|       ::|.||     |....|
Human   256 LEDLEEEEEEEEEAEDEEVVAT--------AGDRLTEFRKG-------AQSLPG-----PCAAAR 300

  Fly   370 PGSMPPGAHPLFHPAALHHHFRPPAGS-PPDIAAYHHHQQQLLQQHQQAQQNSLQTAVGGTAKPR 433
            .|.:......|   ||....|..|:|| ..|..:......:|...:...:            |||
Human   301 EGRLERRECGL---AAPRFSFNDPSGSEEADFLSAETGSPRLTMHYPCLE------------KPR 350

  Fly   434 IWSLADMASKDSKDSSSGAKDNHPELPPAHPGFYGHPGQQPSPGKILSPLAARIPNYSPYVRPD- 497
            |||||..|:..:.:   ||....|.  |..|.....|||.|:..:.||     :|..|......
Human   351 IWSLAHTATASAVE---GAPPARPR--PRSPECRMIPGQPPASARRLS-----VPRDSACDESSC 405

  Fly   498 LYRGFYGPAAAHLGAP 513
            :.:.|..|..|..|.|
Human   406 IPKAFGNPKFALQGLP 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mirr	NP_001261778.1	Homeobox_KN	243..281	CDD:428673	36/37 (97%)
IRX6	NP_077311.2	COG5576	<145..223	CDD:227863	67/77 (87%)
		Homeobox_KN	165..203	CDD:428673	36/37 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..273		12/64 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..394		11/41 (27%)