DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mirr and Irx6

DIOPT Version :9

Sequence 1:	NP_001261778.1	Gene:	mirr / 39441	FlyBaseID:	FBgn0014343	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_071873.2	Gene:	Irx6 / 64379	MGIID:	1927642	Length:	439	Species:	Mus musculus

Alignment Length:	503	Identity:	157/503 - (31%)
Similarity:	209/503 - (41%)	Gaps:	136/503 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 SPCGPSAGLPALSLVGAPPPGPHSSAPGGAPAPGAGNPPNRCCDTGRTIYTD----PVSGQTICS 138
            ||.|...|..:..||.|     .|||              .||:|.....:|    ..|..|:|.
Mouse     4 SPFGHPYGSTSQFLVSA-----SSSA--------------TCCETAPRPVSDVASASTSASTLCC 49

  Fly   139 CQYDMLNYQRLAAAG----GVPLGVY------PEGMSAYLSGIAADQPPFYA---NPAGIDLKEN 190
            ..||    .||..:.    |..||:|      .:....||:  ...:||...   ||. .:.|:.
Mouse    50 TPYD----SRLLGSARPELGAALGIYGAPYAAAQSYPGYLT--YGPEPPTLCGALNPQ-YEFKDA 107

  Fly   191 LVAGASPWPYPSMYHPYDAAFAGYPFNSY-GMDLNGA-RRKNATRETTSTLKAWLNEHKKNPYPT 253
            ..:.|.....|..|:||:.....|.::.| |::|:.| ||||||||:||.|||||:||:||||||
Mouse   108 AGSFAPSLTQPGAYYPYETTLGQYQYDRYGGVELSSAGRRKNATRESTSALKAWLHEHRKNPYPT 172

  Fly   254 KGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPRNRVDDDDANIDDDDDKNTEDNDLLD 318
            |||||||||||||||||||||||||||||||||||||.|:|:..::......:|.....:.|..|
Mouse   173 KGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKADSGEDSLGCLNGDTKD 237

  Fly   319 AKDSGVGSTDDKDRSGRLGDMMTDRPGESNNSEWSESRPGSPNGSPDLYDRPGSMPPGAHPLFHP 383
            |      :...:.|..||.|:       .:..|..|........:.....|.........||..|
Mouse   238 A------TASQEARGLRLSDL-------EDLEEEEEEEEAEEEAAVSAARRLADFQKSTQPLPAP 289

  Fly   384 AALHHHFRPPAGSPPDIAAYHHHQQQLLQQH---------------QQAQQNSLQTAVGGTA--- 430
            .|               ||    |::.|:..               |..:.:.:....||..
Mouse   290 CA---------------AA----QERCLESRECGLGLPRFSFTEAPQSGEADFITAEPGGPTMIL 335

  Fly   431 ------KPRIWSLADMASKDSKDSSSGAKDNHPELPP--AHPGFYGHPGQQPSPGKILSPL---- 483
                  ||||||||..|:..:.:|:       |..||  ..|..:..|.|..|..::|.|.
Mouse   336 HYPSGHKPRIWSLAHTAAASAVESA-------PSTPPRAQSPECHMIPRQPSSIRRLLVPRDSEG 393

  Fly   484 -----AAR-----------IP-NYSPYVR---PDLYRGFYGPAAAHLG 511
                 ||:           :| |.:||.|   |::  .|..|:.|..|
Mouse   394 EEDSPAAKAFGNSTFTLQGLPLNCAPYPRRREPEV--RFQYPSGAEAG 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mirr	NP_001261778.1	Homeobox_KN	242..281	CDD:283551	36/38 (95%)
Irx6	NP_071873.2	COG5576	<142..232	CDD:227863	64/89 (72%)
		Homeobox_KN	161..200	CDD:283551	36/38 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..270		17/77 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	1	1.000	-	-		FOG0001669
OrthoInspector	1	1.000	-	-		mtm8793
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5654
SonicParanoid	1	1.000	-	-		X1407
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.910