DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mirr and Irx5

DIOPT Version :9

Sequence 1:	NP_001261778.1	Gene:	mirr / 39441	FlyBaseID:	FBgn0014343	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_061296.1	Gene:	Irx5 / 54352	MGIID:	1859086	Length:	484	Species:	Mus musculus

Alignment Length:	584	Identity:	186/584 - (31%)
Similarity:	230/584 - (39%)	Gaps:	197/584 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PQ----SPPSTLPTLACPAAQPLSAPGIAGPGHSGMVTSTVPPGARSTSPCGPSAGLPALSLVGA 94
            ||    .|.::|...:|||   .|...|:||....:..|:      |.|...|.||..|.:   |
Mouse     4 PQGYLYQPSASLALYSCPA---YSTSVISGPRTDELGRSS------SGSAFSPYAGSTAFT---A 56

  Fly    95 PPPGPHSSAPGGAPAPGAGNPPNRCCDTGRTIYTDPVSGQTICSCQYDMLNYQRLAAAGGVPLGV 159
            |.||.:|....||                     ||.:                 |||...
Mouse    57 PSPGYNSHLQYGA---------------------DPAA-----------------AAAAAF---- 79

  Fly   160 YPEGMSAYLSGIAADQPPFYANPAGIDLKENLVAGASPWPYPSMYHPYDAAFAGYPFNSYGMDLN 224
                  :|: |...|..|..|...|                   ||||.|....||   ||   :
Mouse    80 ------SYV-GSPYDHTPGMAGSLG-------------------YHPYAAPLGSYP---YG---D 112

  Fly   225 GARRKNATRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMT 289
            .|.||||||:.|:|||||||||:||||||||||||||||||||||||||||||||||||||||||
Mouse   113 PAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMT 177

  Fly   290 WEPRNRVDD--DDANI-----DDDDDKNTEDNDLLDAKDSGVG---------------STDDKDR 332
            |.||||.:|  ::.||     |:|:.:..||...|:..:||..               |...|:.
Mouse   178 WTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDLEGPESGGAEQKATAGCERLQGPLSPAGKET 242

  Fly   333 SGRLGDM-MTDRPGESNNSEW------SESRPGSP-------NGSPDLYDRPGSMP-PGAHPL-- 380
            .|.|.|. ..:...|..:.|.      .||.|..|       :..|..   |.|:| ||.||.
Mouse   243 EGSLSDSDFKESSSEGRHDELPRPPRAGESSPAGPATARLAEDAGPHY---PASVPAPGPHPSAG 304

  Fly   381 -FHP----AALHHHFRPPAGSPPDIAAYHHHQQQLLQQHQQAQQNSLQTAVGGTAKPRIWSLADM 440
             ..|    :::.|...||...||.:                            .|||::||||::
Mouse   305 ELPPGSGGSSVIHSPPPPPPPPPAV----------------------------LAKPKLWSLAEI 341

  Fly   441 ASKDSKDSSSGAKDNHPELPPAHPGFYGHPGQ-------QPSPGKILSPLA-ARIPNYSPYVRPD 497
            |:...|....|........||. ||..|  ||       .|:|....||.| ...|..:...||.
Mouse   342 ATSSDKVKDGGGGSEGSPCPPC-PGPMG--GQTLGGSRASPAPAPARSPSAQCPFPGGTVLSRPL 403

  Fly   498 LYRGFYGPAAAHLGAPTQEFLEHQRTFGASLAAHNGPLGMNPLLWKAAVSGAANGHHFAPLSLT 561
            .|...:.|...:.|           :|| .|..|.|| |.:|.        |..|.||..|:.|
Mouse   404 YYTAPFYPGYTNYG-----------SFG-HLHGHPGP-GPSPT--------AGPGSHFNGLNQT 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mirr	NP_001261778.1	Homeobox_KN	242..281	CDD:283551	37/38 (97%)
Irx5	NP_061296.1	Homeobox_KN	130..169	CDD:283551	37/38 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..393		64/250 (26%)
		IRO	328..345	CDD:214716	8/44 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..443		9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	0.375	Domainoid score	I8067
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	181	1.000	Inparanoid score	I3968
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5654
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.950