DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mirr and irx4b

DIOPT Version :9

Sequence 1:	NP_001261778.1	Gene:	mirr / 39441	FlyBaseID:	FBgn0014343	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001018329.2	Gene:	irx4b / 474318	ZFINID:	ZDB-GENE-040712-4	Length:	439	Species:	Danio rerio

Alignment Length:	536	Identity:	163/536 - (30%)
Similarity:	229/536 - (42%)	Gaps:	138/536 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GHSGMVTSTVPPGARSTSPCGPSAGLPALSLVGAPPPGPHSSAPGGAPAPGAGNPPNRCCDTGRT 125
            |:|......:...:.:.|.|..|:|               |....|.|.    :|.|       :
Zfish     7 GYSYPAAPQLLMSSNALSTCFESSG---------------SLLDSGVPT----SPQN-------S 45

  Fly   126 IYTDPVSGQTICSCQYDMLNYQRLAAAGGVPLGVYPEGMS---AY--LSGIAADQPPFYANPAG- 184
            :|......:.:.|.::::           :|..||....|   .|  .|....|....|  |.|
Zfish    46 LYCPVYESRLVASSRHEL-----------IPTAVYGNSCSKNHVYDSCSTYGPDSAACY--PLGK 97

  Fly   185 IDLKENLVAGASPWPYPSMYHPYDAAFAGYPFNSYG---MDLNGARRKNATRETTSTLKAWLNEH 246
            ::.|:.:..|.|.....|.|:|||.....|.::.||   :|: |.|||||||||||||||||.||
Zfish    98 LNEKDGVQTGHSRVTQSSAYYPYDYPIGQYSYDRYGYGSVDV-GTRRKNATRETTSTLKAWLQEH 161

  Fly   247 KKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPRNRVDDDDANIDDDDDKNT 311
            ||||||||||||||||||||||||||||||||||||||||||||.|||: :.|:...|||.:
Zfish   162 KKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWSPRNK-NSDEKECDDDQE--- 222

  Fly   312 EDNDLLDAKDSGVGSTDD------KDRSGRLGDMMTDRP-GESNNSEWSESRP-------GSPNG 362
               ||.:|::..:.:..|      ||.:.:|...:.|.. .||:.|| .||:|       ...:.
Zfish   223 ---DLDEAQEEPIKTEQDFNDNHGKDDTDQLHSDLDDFDLVESDGSE-CESKPSFVVHVHSETSD 283

  Fly   363 SPDLYDRPGSMPPGAHPLFHPAALH-----HHF-----RPPAGSPPDIAAYHHHQQQLLQQHQQA 417
            .|:.:.:..         ||.:...     |.|     |.||           ...|:.:.:.|.
Zfish   284 HPETHFKDA---------FHESVTELTRGVHKFSEDRLRAPA-----------EDHQMAKFYLQQ 328

  Fly   418 QQNSLQTAVGGTAKPRIWSLADMASKDSKDSSSGAKDNHPELPPAHPGFYGHPGQQPSPGKILSP 482
            .|.:::|      ||:|||||..|:..::...|.........|.::    .....:.:..|..||
Zfish   329 GQKTIET------KPKIWSLAQTATSLNQVDYSSCMHKRTACPSSN----CDSDSEMTKRKQESP 383

  Fly   483 LAARIPNYSPYVRPDLYRGFYGPAAAHLGAPTQEFLEHQRTFGASLAAHNGPLGMNPLLWKAAVS 547
            :|. :.|:...|       |:.|...|...        .:||..|..           ||..|:|
Zfish   384 VAT-LRNWVDGV-------FHDPLFRHNNL--------NQTFSNSTE-----------LWTDAIS 421

  Fly   548 GAANGHHFAPLSLTTS 563
            ...|.|..:...:|:|
Zfish   422 SQNNYHEHSGTPITSS 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mirr	NP_001261778.1	Homeobox_KN	242..281	CDD:283551	37/38 (97%)
irx4b	NP_001018329.2	Homeobox_KN	157..196	CDD:283551	37/38 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3789
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	1	1.000	-	-		FOG0001669
OrthoInspector	1	1.000	-	-		mtm6453
orthoMCL	1	0.900	-	-		OOG6_112784
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5654
SonicParanoid	1	1.000	-	-		X1407
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.860