Protein Alignment mirr and MEIS2

DIOPT Version :9

• Sequence 1: NP_001261778.1
• Gene: mirr / 39441
• FlyBaseID: FBgn0014343
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_733775.1
• Gene: MEIS2 / 4212
• HGNCID: 7001
• Length: 477
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 103/503 - (20%)
• Similarity: 150/503 - (29%)
• Gaps: 210/503 - (41%)

  Fly    85 GLPALSLVGAP------PP------GP--HSSAPGGAPAP-------GAGNPPNRCCDTGR-TIY 127
            |:|| |:.|.|      ||      ||  |::...||.||       ..|:..|......: .||
Human    18 GVPA-SMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIY 81

  Fly   128 TDP-----------------------VSGQTICSCQYDMLNYQRLAAAGGVPLGVYPEGMSAYLS 169
            ..|                       |:|..:||.  |..|                |.::.:..
Human    82 GHPLFPLLALVFEKCELATCTPREPGVAGGDVCSS--DSFN----------------EDIAVFAK 128

  Fly   170 GIAADQPPFYANP-----------------------------------------AGIDLKENLVA 193
            .:.|::|.|.:||                                         ..|||..:...
Human   129 QVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERD 193

  Fly   194 GASPWPY--------------PSMYHPYDAA----FAGYPFNSYG-------------------- 220
            |:|...:              ||.:..:|.|    .||.|..|.|
Human   194 GSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNS 258

  Fly   221 -----------MDLNGARRKNA---TRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQV 271
                       .|.:..|:|..   .:..|:.::|||.:|..:|||::.:|..||..|.:|:.||
Human   259 VASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQV 323

  Fly   272 STWFANARRRLKKENKMTWEPRNRVDDDDANIDDDDDKNTEDNDLLDAKDSGVGSTDDKDRSGRL 336
            :.||.|||||:                    :....|::.....|||...|...:...:.:.  :
Human   324 NNWFINARRRI--------------------VQPMIDQSNRAGFLLDPSVSQGAAYSPEGQP--M 366

  Fly   337 GDMMTD-------RPGESNNSEWSESRPGSPNGSPDLYDRPGSMPPGAHPLFHPAALHH------ 388
            |..:.|       ||....:........|.|.|..  ..:|...||...|  ||..|.|
Human   367 GSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMS--MAQPSYTPPQMTP--HPTQLRHGPPMHS 427

  Fly   389 ----HFRPPA----GSPPDIAAYHHHQQQLLQQHQQAQQNSLQTAVGG 428
                |...||    |.||.      |....:........||:...|||
Human   428 YLPSHPHHPAMMMHGGPPT------HPGMTMSAQSPTMLNSVDPNVGG 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mirr	NP_001261778.1	Homeobox_KN	242..281	CDD:283551	18/38 (47%)
MEIS2	NP_733775.1	Required for interaction with PBX1. /evidence=ECO:0000250	71..191		18/137 (13%)
		Meis_PKNOX_N	110..194	CDD:406806	14/101 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..283		14/89 (16%)
		Homeobox_KN	294..333	CDD:399131	18/38 (47%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:26550823, ECO:0000305|Ref.16	299..333		15/33 (45%)
		PAT1	<335..>463	CDD:401645	28/139 (20%)
		Transcriptional activation domain	340..477		32/142 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900