DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mirr and Tgif2

DIOPT Version :9

Sequence 1:	NP_001261778.1	Gene:	mirr / 39441	FlyBaseID:	FBgn0014343	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_775572.1	Gene:	Tgif2 / 228839	MGIID:	1915299	Length:	237	Species:	Mus musculus

Alignment Length:	197	Identity:	53/197 - (26%)
Similarity:	76/197 - (38%)	Gaps:	54/197 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 MDLNGARRK--NATRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLK 283
            :.|.|.|::  |..:|:...|:.||..|:.|.||::.||:.|:..|.:::.|:..||.||||||.
Mouse    13 LSLTGKRKRRGNLPKESVKILRDWLYLHRYNAYPSEQEKLSLSGQTNLSVLQICNWFINARRRLL 77

  Fly   284 KENKMTWEPRNRVDDDDANIDDDDDKNTEDNDLL--DAKDSGVGSTDDKDRSGRLGDMMTDRPGE 346
            .                              |:|  |.||....:.  ..|.|:..|:..  |..
Mouse    78 P------------------------------DMLRKDGKDPNQFTI--SRRGGKASDVAL--PRG 108

  Fly   347 SNNSEWSESRPGSPN------GSPDLYDRPGSMPPGAHP---------LFHPAA-LHHHFRPPAG 395
            |:.|..:.|.|...|      .|..|:...|..|....|         |..||: |....|..||
Mouse   109 SSPSLLAVSVPAPTNMLSLSVCSMPLHSGQGEKPAAPFPQVELESPKALVTPASTLTLLTRAEAG 173

  Fly   396 SP 397
            ||
Mouse   174 SP 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mirr	NP_001261778.1	Homeobox_KN	242..281	CDD:283551	16/38 (42%)
Tgif2	NP_775572.1	Homeobox_KN	36..75	CDD:368670	16/38 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..106		4/22 (18%)
		Repressive function	103..237		20/75 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..196		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..237
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900