DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mirr and Meis2

DIOPT Version :9

Sequence 1:	NP_001261778.1	Gene:	mirr / 39441	FlyBaseID:	FBgn0014343	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	XP_011237639.1	Gene:	Meis2 / 17536	MGIID:	108564	Length:	559	Species:	Mus musculus

Alignment Length:	376	Identity:	90/376 - (23%)
Similarity:	128/376 - (34%)	Gaps:	102/376 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SAGLPALSLVGAPPPGPHSSAPG-GAPAPGAGNPPNRCCDTGRTIYTDPVSGQTICSCQYDMLNY 146
            |||.|      .|..|.|:|..| .:...||..     .:....:...|::.:|.| ....|...
Mouse   248 SAGTP------GPSSGGHASQSGDNSSEQGASE-----TEADHLLLWKPMTDRTGC-VSVQMSRE 300

  Fly   147 QRLAAAGG----VPLGVYPEGMSAYLSGIAADQPPFYA-NPAGIDLKENLVAGASPWPYPSMYHP 206
            .|..:..|    .||    |.:      |...||||.. :.||.|..:|.||.      |.....
Mouse   301 DREESREGKHSPQPL----ENI------IIPCQPPFRGESEAGGDGLDNSVAS------PGTGDD 349

  Fly   207 YDAAFAGYPFNSYGMDLNGARRKNA---TRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTL 268
            .|.            |.:..|:|..   .:..|:.::|||.:|..:|||::.:|..||..|.:|:
Mouse   350 DDP------------DKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTI 402

  Fly   269 TQVSTWFANARRRLKKENKMTWEPRNRVDDDDANIDDDDDKNTEDNDLLDAKDSGVGSTDDKDRS 333
            .||:.||.|||||:                    :....|::.....|||...|...:...:.:.
Mouse   403 LQVNNWFINARRRI--------------------VQPMIDQSNRAGFLLDPSVSQGAAYSPEGQP 447

  Fly   334 GRLGDMMTD-------RPGESNNSEWSESRPGSPNGSPDLYDRPGSMPPGAHPLFHPAALHH--- 388
              :|..:.|       ||....:........|.|.|..  ..:|...||...|  ||..|.|
Mouse   448 --MGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMG--MAQPSYTPPQMTP--HPTQLRHGPP 506

  Fly   389 -------HFRPPA----GSPPDIAAYHHHQQQLLQQHQQAQQNSLQTAVGG 428
                   |...||    |.||.      |....:........||:...|||
Mouse   507 MHSYLPSHPHHPAMVMHGGPPT------HPGMTMSAQSPTMLNSVDPNVGG 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mirr	NP_001261778.1	Homeobox_KN	242..281	CDD:283551	18/38 (47%)
Meis2	XP_011237639.1	Meis_PKNOX_N	129..213	CDD:374576
Meis2	XP_011237639.1	Homeobox_KN	376..415	CDD:368670	18/38 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900