Protein Alignment mirr and Irx1

DIOPT Version :9

• Sequence 1: NP_001261778.1
• Gene: mirr / 39441
• FlyBaseID: FBgn0014343
• Length: 682
• Species: Drosophila melanogaster
• Sequence 2: NP_034703.2
• Gene: Irx1 / 16371
• MGIID: 1197515
• Length: 480
• Species: Mus musculus
• Alignment Length: 621
• Identity: 189/621 - (30%)
• Similarity: 243/621 - (39%)
• Gaps: 199/621 - (32%)

  Fly    40 TLPTLACPAAQPLSAPGIAGPGHSGMVTSTVPPGARSTSPCGPSAGLPALSLVGAPPPGPHSSAP 104
            :.|.|..|  |.|||   ||||..|        |.|                     ||..::|.
Mouse     2 SFPQLGYP--QYLSA---AGPGAYG--------GER---------------------PGVLAAAA 32

  Fly   105 GGAPAPGAGNPPNRCCDTGRTIYTDPVSGQTICSCQYDMLNYQRLAAAG---GVPLGVYPEGMSA 166
            ..|.|..:|.|.......|        :|....:....|     .||||   |.|      ..||
Mouse    33 AAAAAASSGRPGTAELGAG--------AGAAAVTSVLGM-----YAAAGPYAGAP------NYSA 78

  Fly   167 YLSGIAADQPPFYANPAGIDLKENLVAGASPWPYPSMYHPYDAAFAGYPFN--SYGMDLNGARRK 229
            :|. .|||...|....:..:||:|      |..:|:.:..:... |.||:.  .||   :..|.|
Mouse    79 FLP-YAADLSLFSQMGSQYELKDN------PGVHPATFAAHTTP-AYYPYGQFQYG---DPGRPK 132

  Fly   230 NATRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPRN 294
            |||||:|||||||||||:||||||||||||||||||||||||||||||||||||||||:||..|:
Mouse   133 NATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARS 197

  Fly   295 RVDDDDANIDDD---DDKNTEDNDLLDAKDSGVGSTDDKDRSGRLGDMMTDRPGESNNSEWSESR 356
            :..:|.|....|   |.:..||::.:|.:...:...|::|     ||...:  .|.:.:|...:|
Mouse   198 KDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDQIDERD-----GDQSNE--DEEDKAEAPRAR 255

  Fly   357 PGSPNGSPD------------LYDRPGSM-----PPGAHPLFHPAALHHHFRPPAGSPPDIAAYH 404
            ...|..:.|            ..|.|..:     .||:..|..|.|
Mouse   256 VAPPASARDQSSPLSAAETLKSQDSPLGLVKEVSEPGSTRLLSPGA------------------- 301

  Fly   405 HHQQQLLQQHQQAQQNSLQTAVG--GT--AKPRIWSLADMASKDSKDSSSGAKDNHPELPPAHPG 465
                               .|||  |.  :||:|||||:.|:     |..||....|..|.:|..
Mouse   302 -------------------AAVGLQGAPHSKPKIWSLAETAT-----SPDGAPKASPPPPSSHAS 342

  Fly   466 FYGHPGQQPSPGKILSPLAARIPNYSPYVRPDLYRGFYGPAAAHLGAPTQEFLEHQRTFGASLAA 530
            .:|.|...|    :..|  |.:|::..|             ..|:|    :|  ...|.||.| |
Mouse   343 AHGPPSGSP----LQHP--AFLPSHGLY-------------TCHIG----KF--SNWTNGAFL-A 381

  Fly   531 HNGPLGMNPLLWKAAVSGAANGHHFAPLSLTTSGGSSGGQQVAPPPVASP-------------SA 582
            ....|.|...|..:|...|.:|.|.                .||||...|             ||
Mouse   382 QGSLLNMRSFLGVSAPHAAPHGPHL----------------TAPPPPQPPVQVATGVLHGEKASA 430

  Fly   583 SSSSSSMGCDVVHIPTSSGQSAAQHMMGPISSNSTA 618
            .||.:....|:|..|.|..|....... |:..||.|
Mouse   431 RSSPALPERDLVTRPDSPPQQLKSPFQ-PVRDNSLA 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mirr	NP_001261778.1	Homeobox_KN	242..281	CDD:283551	37/38 (97%)
Irx1	NP_034703.2	Homeobox_KN	145..184	CDD:283551	37/38 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..285		22/101 (22%)
		SDA1	<194..>252	CDD:283052	14/64 (22%)
		IRO	309..326	CDD:214716	8/21 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..354		13/44 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	401..480		20/82 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	0.375	Domainoid score	I8067
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5654
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.910