DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mirr and irx1

DIOPT Version :9

Sequence 1:	NP_001261778.1	Gene:	mirr / 39441	FlyBaseID:	FBgn0014343	Length:	682	Species:	Drosophila melanogaster
Sequence 2:	NP_001188351.1	Gene:	irx1 / 100038208	XenbaseID:	XB-GENE-486817	Length:	467	Species:	Xenopus tropicalis

Alignment Length:	525	Identity:	156/525 - (29%)
Similarity:	210/525 - (40%)	Gaps:	169/525 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 YDMLNYQRLAAAGGVPL--GVYPEGMSAYLSGIAADQPPFYANPAGIDLKENLVAG--------A 195
            :..|.|.:..:||...:  |..|..::|..:..||........|.|.||..:..|.        |
Frog     3 FPQLGYPQYLSAGQAAVYGGERPGVLAAAAAAAAAAAAAGSGRPTGADLGSSSTAAVTSVLGMYA 67

  Fly   196 SPWPYP--SMYHPY-----------------------DAAFAG------YPFN--SYGMDLNGAR 227
            ||:..|  |.:.||                       .|.||.      ||:.  .||   :..|
Frog    68 SPYSAPNYSAFLPYTTDLTLFSQMGSQYELKDNPGVHPATFAAHTTPGYYPYGQFQYG---DPGR 129

  Fly   228 RKNATRETTSTLKAWLNEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEP 292
            .||||||:|||||||||||:||||||||||||||||||||||||||||||||||||||||:||..
Frog   130 PKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKVTWGA 194

  Fly   293 RNRVDDD--DANIDDDDDKNTEDNDLLDAKDSGVGSTDDKDRSGRLGDMMTDRPGESNNSEWSES 355
            |::.||:  .::.:.|.:|| ||::.:|.:...:...||.|             ||.:|.|..|.
Frog   195 RSKEDDNIFGSDTEGDHEKN-EDDEEIDLESIDIDKIDDND-------------GEQSNEEEDEK 245

  Fly   356 RPGSPNGSPDLYDRPGS-MPPGAHPLFHPAALHHHFRPPAGSPPDIAAYHHHQQQLLQQHQQAQQ 419
            ......|..:.:.:... |.|.:..|....:|.                       |.:......
Frog   246 LEHLRQGEKESFKKESEVMIPSSDGLKSKDSLS-----------------------LGKESSDTS 287

  Fly   420 NSLQTAVGGTA--------KPRIWSLADMASKDS---KDSSSGAKDNHPELPPAHPGFYGHPGQQ 473
            |:...:.||..        ||:|||||:.|:...   |.|...::.||...|..||.|
Frog   288 NTRIVSPGGQGNIQVPPHNKPKIWSLAETATSPDGALKSSPPPSQANHTSPPIQHPAF------- 345

  Fly   474 PSPGKILSPLAARIPNYSPYVRPDLYRGFYGPAAAHLGAPTQEFLEHQRTFGA-----SLAAHNG 533
                         :|::..|             ...:|    :|  |..|.||     ||.....
Frog   346 -------------LPSHGLY-------------TCQIG----KF--HNWTNGAFLTQSSLINMRS 378

  Fly   534 PLGMNPLLWKAAVSGAANGHHF------APL---SLTTSGGSSGGQQVAP-------------PP 576
            .||:||      ...|.:.||.      |||   :|::.......::.:|             ||
Frog   379 LLGVNP------HHVAHHNHHHLQAHQQAPLLATNLSSLSSDKTPERTSPKHSDRENLPRTESPP 437

  Fly   577 VASPS 581
            ...||
Frog   438 QLKPS 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mirr	NP_001261778.1	Homeobox_KN	242..281	CDD:283551	37/38 (97%)
irx1	NP_001188351.1	Homeobox_KN	144..183	CDD:283551	37/38 (97%)
irx1	NP_001188351.1	IRO	303..320	CDD:214716	8/16 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I7951
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5654
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.050