Protein Alignment caup and IRX1

DIOPT Version :9

• Sequence 1: NP_524046.2
• Gene: caup / 39440
• FlyBaseID: FBgn0015919
• Length: 693
• Species: Drosophila melanogaster
• Sequence 2: NP_077313.3
• Gene: IRX1 / 79192
• HGNCID: 14358
• Length: 480
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 164/578 - (28%)
• Similarity: 235/578 - (40%)
• Gaps: 188/578 - (32%)

  Fly    86 GGDVPVGLSSAAQDLPSRGSCCENGRPIITDPVSGQTVCSCQYDPARLAIGGYSRMALPSGGVGV 150
            ||:.|..|::||    :..:...:||                  |....:||.:..|..:..:|:
Human    21 GGERPGVLAAAA----AAAAAASSGR------------------PGAAELGGGAGAAAVTSVLGM 63

  Fly   151 GVYGGPYPSNEQN-----PYPSIGVDNSAFYAPLSNPYGIKDTSPSTEMSAWTSASLQSTTGYYS 210
            ....||| :...|     ||.:    :.:.::.:.:.|.:|| :|....:.:.:   .:...||.
Human    64 YAAAGPY-AGAPNYSAFLPYAA----DLSLFSQMGSQYELKD-NPGVHPATFAA---HTAPAYYP 119

  Fly   211 YDPTLAAYGYGPNYDLAARRKNATRESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVST 275
            |    ..:.||.    ..|.||||||||:||||||:||:||||||||||||||||||||||||||
Human   120 Y----GQFQYGD----PGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVST 176

  Fly   276 WFANARRRLKKENKMTWEPKNKTEDDDDGMMSDDEKEKD---AGDGGKLSTEAFDPGNQLIKSEL 337
            ||||||||||||||:||..::|  |.:||.:...:.|.|   |.|..::..|:.|
Human   177 WFANARRRLKKENKVTWGARSK--DQEDGALFGSDTEGDPEKAEDDEEIDLESID---------- 229

  Fly   338 GKAEKEVDSSGDQKLDLDREPHNLVAMRGLAPYATPPGAHPMHAAYSSYAQSHNTHTHPHPQQMQ 402
              .:|..:..|||..:.|.:       :..||:|.        ||.|:.|:...:
Human   230 --IDKIDEHDGDQSNEDDED-------KAEAPHAP--------AAPSALARDQGS---------- 267

  Fly   403 HHQQQQQQQQNQQQLQHHQMDQPYYHPGGYGQE--ESGEFAAQKNPLSRDCGIP-VPASKPKIWS 464
                         .|....:.:|...|.|..:|  |.|. ....:|.:...|:. .|..||||||
Human   268 -------------PLAAADVLKPQDSPLGLAKEAPEPGS-TRLLSPGAAAGGLQGAPHGKPKIWS 318

  Fly   465 VADTAAC------KTPPPTAAYLGQNFYPPSSADQQLPHQPLQQHQQQQLQQLQQQQQHHHHP-- 521
            :|:||..      .:|||.|.:.|.  :.||:.      .|||                  ||
Human   319 LAETATSPDGAPKASPPPPAGHPGA--HGPSAG------APLQ------------------HPAF 357

  Fly   522 ---HHHHPHH-----------SMELGSPLSMMSSYAGGSPYSRIPTAYTEAMGMHLPSSSSSSSS 572
               |..:..|           .:..||.|:|.|....|:|::       ...|.|||:
Human   358 LPSHGLYTCHIGKFSNWTNSAFLAQGSLLNMRSFLGVGAPHA-------APHGPHLPA------- 408

  Fly   573 TGKLPPTHIHPAPQRVGFPEIQPDTPPQTPPTMKLNSSGGSSSSSGSSHSSSMHSVTP 630
                ||                   |||.|..:...:..|..:|..||.:.....:.|
Human   409 ----PP-------------------PPQPPVAIAPGALNGDKASVRSSPTLPERDLVP 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	244..283	CDD:283551	36/38 (95%)
		IRO	455..472	CDD:214716	10/22 (45%)
IRX1	NP_077313.3	Homeobox_KN	145..184	CDD:399131	36/38 (95%)
		HARE-HTH	<188..247	CDD:412843	20/72 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..268		25/129 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	280..354		27/100 (27%)
		IRO	<313..326	CDD:214716	9/12 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	401..480		15/73 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.880