DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment caup and IRX6

DIOPT Version :9

Sequence 1:	NP_524046.2	Gene:	caup / 39440	FlyBaseID:	FBgn0015919	Length:	693	Species:	Drosophila melanogaster
Sequence 2:	NP_077311.2	Gene:	IRX6 / 79190	HGNCID:	14675	Length:	446	Species:	Homo sapiens

Alignment Length:	469	Identity:	160/469 - (34%)
Similarity:	212/469 - (45%)	Gaps:	127/469 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 HAGH--KGLSTSPAEDVVGGDVPVGLSSAAQDLPSRGSCCENGRPIITDPVSGQT----VCSCQY 128
            |.||  :|.|..             |:||:    |..:|||:.:..::|..||.|    :|...|
Human     5 HFGHPYRGASQF-------------LASAS----SSTTCCESTQRSVSDVASGSTPAPALCCAPY 52

  Fly   129 DPARLAIGGYSRMALPSGGVGVGVYGGPY-PSNEQNPYPS---IGVDNSAFYAPLSNPYGIKDTS 189
            |...|.      .|.|..|..:|:||.|| .:.....||.   ...:..:.|..|:..|..|:.:
Human    53 DSRLLG------SARPELGAALGIYGAPYAAAAAAQSYPGYLPYSPEPPSLYGALNPQYEFKEAA 111

  Fly   190 PSTEMSAWTSASLQSTTGYYSYDPTLAAYGYGPNYDL-----AARRKNATRESTATLKAWLSEHK 249
            .|     :|| ||.....||.|:.||..|.| ..|..     |.||||||||:|:||||||:||:
Human   112 GS-----FTS-SLAQPGAYYPYERTLGQYQY-ERYGAVELSGAGRRKNATRETTSTLKAWLNEHR 169

  Fly   250 KNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNK---------TEDDDDGM 305
            |||||||||||||||||||||||||||||||||||||||||||.||||         .|:|..|.
Human   170 KNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGC 234

  Fly   306 MSDDEKEKDAGD---GGKLSTEAFDPGNQLIKSELGKAEKEVDSSGDQKLDLDREPHNLVAMRGL 367
            ::.|.||..|..   |.:|| :..|...:..:.|..:.|:.|.::||:..:..:...:|
Human   235 LTADTKEVTASQEARGLRLS-DLEDLEEEEEEEEEAEDEEVVATAGDRLTEFRKGAQSL------ 292

  Fly   368 APYATPPGAHPMHAAYSSYAQSHNTHTHPHPQQMQHHQQQQQQQQNQQQLQHHQMDQP---YYHP 429
                  ||  |..||                            ::.:.:.:...:..|   :..|
Human   293 ------PG--PCAAA----------------------------REGRLERRECGLAAPRFSFNDP 321

  Fly   430 GGYGQEESGEFAAQKNPLSRDCGIP-----VPA-SKPKIWSVADTA---ACKTPPPTAAYLGQNF 485
            .|   .|..:|      ||.:.|.|     .|. .||:|||:|.||   |.:..||...
Human   322 SG---SEEADF------LSAETGSPRLTMHYPCLEKPRIWSLAHTATASAVEGAPPARP------ 371

  Fly   486 YPPSSADQQLPHQP 499
            .|.|...:.:|.||
Human   372 RPRSPECRMIPGQP 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	244..283	CDD:283551	36/38 (95%)
caup	NP_524046.2	IRO	455..472	CDD:214716	10/20 (50%)
IRX6	NP_077311.2	Homeobox_KN	164..203	CDD:283551	36/38 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..273		21/65 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..394		8/30 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9609
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3917
Isobase	1	0.950	-	0	Normalized mean entropy	S3756
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351833at33208
OrthoFinder	1	1.000	-	-		FOG0001669
OrthoInspector	1	1.000	-	-		mtm8566
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1407
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.880