Protein Alignment caup and TGIF2

DIOPT Version :10

• Sequence 1: NP_524046.2
• Gene: caup / 39440
• FlyBaseID: FBgn0015919
• Length: 693
• Species: Drosophila melanogaster
• Sequence 2: NP_068581.1
• Gene: TGIF2 / 60436
• HGNCID: 15764
• Length: 237
• Species: Homo sapiens
• Alignment Length: 315
• Identity: 72/315 - (22%)
• Similarity: 104/315 - (33%)
• Gaps: 115/315 - (36%)

  Fly   226 LAARRK---NATRESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKE 287
            ||.:||   |..:||...|:.||..|:.|.||::.||:.|:..|.:::.|:..||.||||||..:
Human    15 LAGKRKRRGNLPKESVKILRDWLYLHRYNAYPSEQEKLSLSGQTNLSVLQICNWFINARRRLLPD 79

  Fly   288 NKMTWEPKNKTEDDDDGMMSDDEKEKDAGDGGKLSTEAFDPGNQLIKSELGKAEKEVDSSGDQKL 352
                             |:..|.|               ||....|....|||
Human    80 -----------------MLRKDGK---------------DPNQFTISRRGGKA------------ 100

  Fly   353 DLDREPHNLVAMRGLAPYATPPGAHPMHAAYSSYAQSHNTHTHPHPQQMQHHQQQQQQQQNQQQL 417
                           :..|.|.|:.|...|.|.          |.|..:               |
Human   101 ---------------SDVALPRGSSPSVLAVSV----------PAPTNV---------------L 125

  Fly   418 QHHQMDQPYYHPGGYGQEESGEFAAQKNPLSRDCGIPVPASKPKIWSVADTAA-----CKTPPPT 477
            .......|.:  .|.|::.:..|  .:..|.....:..|.|...:.:.|:..:     ..|||||
Human   126 SLSVCSMPLH--SGQGEKPAAPF--PRGELESPKPLVTPGSTLTLLTRAEAGSPTGGLFNTPPPT 186

  Fly   478 AAYLGQNFYPPS------SADQQLPHQPLQQHQQQQLQQLQQQQQHHHHPHHHHP 526
                     ||.      |:.|.|....||:..:.:|    |:||....|..|.|
Human   187 ---------PPEQDKEDFSSFQLLVEVALQRAAEMEL----QKQQDPSLPLLHTP 228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
caup	NP_524046.2	Homeobox_KN	245..283	CDD:428673	15/37 (41%)
		IRO	455..472	CDD:214716	3/21 (14%)
TGIF2	NP_068581.1	Homeobox_KN	37..75	CDD:428673	15/37 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..106		7/45 (16%)
		Repressive function	103..237		36/168 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	172..193		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..237		7/20 (35%)